279 RESULTS
RESEARCH NEWS 2019-09-04 Research News Are microglia the masterminds of amyloid plaque formation? In the August 21 Nature Communications, researchers led by Kim Green at the University of California, Irvine, suggest these cells seed amyloid deposits. In a mouse model of amyloidos
RESEARCH NEWS 2018-09-25 Research News Kiss those smooth, sigmoidal curves goodbye, and embrace the jumbled complexity of spaghetti plots. Longitudinal data charting the trajectories of a bevy of biomarkers in people with autosomal-dominant AD (ADAD) was published September 20 in
RESEARCH NEWS 2018-10-05 Research News Mutations in the C9ORF72 gene cause both the fatal motor-neuron disease amyotrophic lateral sclerosis and frontotemporal dementia, the second-leading cause of early onset dementia after Alzheimer’s. The gene may bear other bad news, accordin
CONFERENCE COVERAGE 2018-11-02 Conference Coverage Currently, hopes for an Alzheimer’s prevention therapy hang on BACE inhibitors that squelch generation of Aβ peptides. When these compounds failed to slow cognitive decline in symptomatic patients, researchers argued that they might wo
RESEARCH NEWS 2019-01-04 Research News In the weeks following a stroke, regulatory T cells stream into the brain. What exactly do they do there? Scientists led by Akihiko Yoshimura, Keio University School of Medicine, Tokyo, report in the January 2 Nature that these cells dampen
RESEARCH NEWS 2019-01-07 Research News In neurodegenerative disease, inflammation runs rampant in the brain. But is this a cause or a consequence of pathology? Researchers led by Edward Giniger at the National Institute of Neurological Disorders and Stroke in Bethesda, Maryland,
RESEARCH NEWS 2019-01-11 Research News Researchers would like better ways to image inflammation in the brain. Currently, some use PET tracers targeting the mitochondrial transporter TSPO to measure active microglia, but these ligands are plagued by poor specificity and high varia
RESEARCH NEWS 2019-01-12 Research News Mounting evidence suggests a link between β-amyloid and disrupted sleep. Does the same hold true for tau? Yes, according to a paper published in the January 9 Science Translational Medicine. Using PET imaging, scientists led by Brendan Lucey
RESEARCH NEWS 2019-03-01 Research News Want more evidence of the importance of microglia for Alzheimer’s disease? A study in the February 27 Science Advances suggests that spicing up the metabolism of these cells can tamp down Alzheimer’s pathology. Researchers led by Zengqiang Y
RESEARCH NEWS 2019-03-12 Research News A paper published March 5 in Neuron takes a subcellular look at the biology of TDP-43 aggregation, a feature of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Alzheimer’s disease. The authors, led by Sandrine Da Cruz
RESEARCH NEWS 2019-03-20 Research News The longevity gene klotho keeps memory keen, but how? New research raises the possibility that it might influence cognition through its signaling partners FGF23 and the fibroblast growth factor (FGF) receptor. In the March 7 eNeuro, Gwendaly
RESEARCH NEWS 2019-03-21 Research News Whether sustained on the field or in the ring, repeated blows to the head result in a distinctive strain of tau filaments in the brain. In the March 20 Nature, researchers led by Sjors Scheres and Michel Goedert of the MRC Laboratory of Mole
RESEARCH NEWS 2019-03-25 Research News Does Alzheimer’s disease retard the birth of new neurons in the hippocampus? Data from mouse models suggests it might, but evidence from human brain has been lacking. In today’s Nature Medicine, researchers led by María Llorens-Martín at the
RESEARCH NEWS 2019-04-05 Research News Microglia tend to get off-kilter in Alzheimer’s and other neurodegenerative diseases. Now, researchers in Tony Wyss-Coray’s lab at Stanford University believe they have discovered a means of restoring their homeostasis. On April 3 in Nature
CONFERENCE COVERAGE 2019-05-01 Conference Coverage Despite years of study, ApoE still has secrets to give up. At the 14th International Conference on Alzheimer’s and Parkinson’s Diseases, held March 27–31 in Lisbon, Portugal, researchers indicted ApoE4 on several fronts. They charged i
