279 RESULTS
RESEARCH NEWS 2019-08-09 Research News Geneticists have found dozens of loci that associate with Alzheimer’s disease, but the functional variants and even the genes that underlie these associations often remain elusive. Now, researchers led by Alison Goate and Edoardo Marcora at
RESEARCH NEWS 2018-09-21 Research News BACE1 knockout mice have more than their fair share of problems, but is it because they lack the enzyme during development or during adulthood? New conditional knockouts from the lab of Robert Vassar, Northwestern University, Chicago, sugges
RESEARCH NEWS 2019-01-11 Research News Most of the research on Alzheimer’s biomarkers to date has been done in predominantly white populations, but a few small studies have hinted at possible racial differences. A paper in the January 7 JAMA Neurology supports this idea. Research
RESEARCH NEWS 2019-02-01 Research News Microgliosis goes hand-in-hand with Alzheimer’s disease, but the exact staging remains murky. A neuropathological study in the January 24 Nature Communications now places one type of microglial activation into the AD pathological cascade. Re
RESEARCH NEWS 2019-02-07 Research News A cholesterol metabolite boosts accumulation of phosphorylated tau, according to a paper in the January 16 Cell Stem Cell. Researchers led by Lawrence Goldstein at the University of California, San Diego, reported that cholesteryl esters—whi
RESEARCH NEWS 2019-02-08 Research News Some studies of cerebrospinal fluid biomarkers suggest that women accumulate more tau pathology early in Alzheimer’s disease than do men. In the February 4 JAMA Neurology, researchers led by Rachel Buckley and Reisa Sperling at Massachusetts
RESEARCH NEWS 2019-02-15 Research News One of the characteristic features of Alzheimer’s disease is reduced blood flow in the brain. What brings it down? A paper in the February 11 Nature Neuroscience suggests that white blood cells can clog up the works. Scientists led by Chris
RESEARCH NEWS 2019-02-26 Research News On their own, most genetic variations linked to Alzheimer’s disease affect a person’s risk by a minuscule amount. Together, however, they pack a wallop, at least according to a follow-up study led by Rahul Desikan at the University of Califo
RESEARCH NEWS 2019-03-08 Research News Iron is an essential nutrient, but like any good thing, too much of it may do harm. According to an autopsy study published February 18 in Molecular Psychiatry, people who had had dementia and moderate to high burdens of plaques and tangles
RESEARCH NEWS 2019-03-13 Research News In the March 11 Scientific Reports, researchers led by Noel Faux at IBM Research Australia in Southbank propose yet another blood test for Alzheimer’s disease, this one based on simple immunoassays. The scientists used machine learning to id
RESEARCH NEWS 2019-03-15 Research News New data expands on the benefits of gamma wave therapy previously reported in mouse models of Alzheimer’s disease. Researchers led by MIT scientist Li-Huei Tsai report that sound can entrain gamma oscillations in both the auditory cortex and
RESEARCH NEWS 2019-03-22 Research News Scientists have known for years that the common H1 haplotype of the tau gene MAPT somehow raises a person’s risk of the rare neurodegenerative disorder progressive supranuclear palsy (PSP). It does so by more than fivefold, similar to what A
RESEARCH NEWS 2019-03-29 Research News Women with shorter-than-average reproductive periods are at a markedly increased risk for dementia, according to a paper published March 27 in Neurology. Researchers led by Paola Gilsanz at Kaiser Permanente Division of Research in Oakland a
RESEARCH NEWS 2019-04-11 Research News Results were published today from the APECS trial, a Phase 3 study of the BACE1 inhibitor verubecestat. In the April 11 New England Journal of Medicine, researchers led by Michael Egan, Merck, Kenilworth, New Jersey, reported that dementia p
RESEARCH NEWS 2019-04-12 Research News Chronic traumatic encephalopathy can only be formally diagnosed by examining the brain after death, but researchers are inching closer to spotting the neuropathological hallmarks of disease during life. A study published April 10 in the New
