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Does Oleic Acid Hold the Key to α-Synuclein Toxicity?

RESEARCH NEWS 2018-12-10 Research News Dieticians recommend consuming mostly unsaturated fats for cardiovascular health and a slim waistline. Now, in a surprising twist, researchers claim one such fat, oleic acid, may worsen α-synuclein pathology. In the December 4 Molecular Cell ...

Secreted APP Binds GABA-B Receptors, Blocks Neurotransmitter Release

RESEARCH NEWS 2019-01-13 Research News Though Aβ tends to hog the research spotlight, scientists have steadily built a case for the importance of another APP fragment—secreted APP. Now, a paper in the January 11 Science explains how it tweaks synaptic transmission. Researchers ...

Microtubule Regulator Connects TDP-43 to Axonal Dysfunction

RESEARCH NEWS 2019-01-18 Research News Nearly all cases of amyotrophic lateral sclerosis, and half of frontotemporal dementia ones, are marked by deposits of the RNA-binding protein TDP-43, yet researchers still have little idea how this pathology relates to neurodegeneration. ...

Rogue Gene Networks Track with Neurodegeneration Across Diseases

RESEARCH NEWS 2019-03-01 Research News A sporadic case of neurodegenerative disease likely represents the culmination of myriad gene-expression changes in the brain. How to make sense of the chaos, let alone restore order? In the January Nature Medicine, researchers led by Daniel ...

Cut Loose, Soluble TREM2 Beckons Microglia to Mop Up Plaques

RESEARCH NEWS 2019-04-05 Research News As if the biological functions of membrane-bound TREM2 weren’t complicated enough, researchers also have to contend with the actions of its freewheeling counterpart, soluble TREM2. In the March 25 Nature Communications, researchers led by ...

Aβ Acts Through Pericytes to Throttle Brain Blood Flow

RESEARCH NEWS 2019-06-22 Research News In Alzheimer’s disease, blood flows sluggishly through the brain, partly because Aβ provokes small blood vessels to constrict. In the June 20 Science, researchers led by David Attwell at University College London blame this on pericytes, ...

New PET Staging Scheme for Amyloid?

CONFERENCE COVERAGE 2019-07-25 Conference Coverage Scientists are becoming more nuanced in how they use amyloid scans—not just to detect the presence of Alzheimer’s pathology, but also to pinpoint disease stage. At this year’s Alzheimer’s Association International Conference, held July ...

Cognitive Decline Trips Up API Trials of BACE Inhibitor

RESEARCH NEWS 2019-07-12 Research News The Alzheimer’s field was dealt another body blow yesterday with the announcement of a premature end to testing of Novartis/Amgen’s BACE inhibitor CNP520, aka umibecestat, in two Phase 2/3 trials. Part of the Alzheimer’s Prevention ...

In Alzheimer’s, More TREM2 Is Good for You

RESEARCH NEWS 2019-08-29 Research News Certain mutations in TREM2 strongly increase risk for late-onset Alzheimer’s. Could tweaking the function of this microglial receptor help people with the disease? A new study suggests as much. In the August 28 Science Translational Medicine ...

Blood Pressure: How Low to Prevent Dementia—and When?

RESEARCH NEWS 2019-08-23 Research News Mounting evidence suggests midlife hypertension negatively affects late-life cognition and that treating it could help. Three new papers support this idea. In the August 20 Lancet, researchers led by Marcus Richards, Nick Fox, and Jonathan ...

Newly Identified Microglia Contain Lipid Droplets, Harm Brain

RESEARCH NEWS 2019-08-23 Research News Microglia in the brain assume a dizzying array of states. Now researchers led by Tony Wyss-Coray at Stanford University, Palo Alto, California, describe a new one: lipid droplet-accumulating microglia (LAM). These lipid-stuffed cells ...

AD Genetic Risk Tied to Changes in Microglial Gene Expression

RESEARCH NEWS 2019-08-09 Research News Geneticists have found dozens of loci that associate with Alzheimer’s disease, but the functional variants and even the genes that underlie these associations often remain elusive. Now, researchers led by Alison Goate and Edoardo Marcora at ...

Islands of Mutated Neurons Dot the Brain. Are They Bad for Us?

RESEARCH NEWS 2018-10-23 Research News The genomes we inherit from our parents are not set in stone. After sperm meets egg, and mitosis is on its merry way, mutations occur in our DNA. They give rise to populations of cells harboring unique genomes and indeed, researchers suspect ...

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