271 RESULTS
RESEARCH NEWS 2018-10-05 Research News How do expanded hexanucleotide repeats in the C9ORF72 gene cause amyotrophic lateral sclerosis and frontotemporal dementia? They give rise to aberrant dipeptide repeat proteins, but even though these DPRs form deposits, they correlate poorly
RESEARCH NEWS 2018-10-12 Research News A new model of Parkinson’s disease re-creates key features of the disorder, and helps steady one disputed theory of what causes it. Mice carrying mutations that disrupt physiological tetramers of the α-synuclein protein develop brain patholo
RESEARCH NEWS 2018-11-21 Research News Multiple copies of the amyloid precursor gene crop up in adult neurons of the human brain, creating a heterogeneous neuronal landscape in a single person. This is especially true in brains from people with sporadic Alzheimer’s disease, but h
RESEARCH NEWS 2019-01-16 Research News Evidence for the transmission of Aβ seeds between people keeps accumulating. In the December 31 Annals of Neurology, researchers led by David Werring at University College London describe the cases of three adults with early onset cerebral a
RESEARCH NEWS 2019-01-16 Research News Physical activity may improve cognition, and a paper in the January 8 Nature Medicine makes the case that a peptide shed from muscles during exercise might be responsible. Researchers led by Fernanda De Felice of Federal University of Rio De
RESEARCH NEWS 2019-01-28 Research News Do periodontal bacteria cause some cases of Alzheimer’s disease? Scientists at one start-up think so, and their investors are putting their money where their mouths are, moving forward with clinical development of a bacterial protease inhibi
RESEARCH NEWS 2019-01-31 Research News Yesterday, Roche announced a halt to the Phase 3 CREAD 1 and CREAD 2 trials of the anti-amyloid antibody crenezumab. According to a company press release, an interim analysis found the trial was unlikely to reach its primary endpoint of slo
RESEARCH NEWS 2019-02-05 Research News Three years ago in a high-profile paper, researchers led by Michal Schwartz at the Weizmann Institute of Science in Rehovot, Israel, deployed an immune-boosting approach pioneered for cancer in a mouse model of Alzheimer’s disease. The resul
RESEARCH NEWS 2019-02-08 Research News A damaged and leaky blood-brain barrier contributes to dementia, but just how has not been clear. Previous work implicated the clotting protein fibrinogen, which, when it penetrates the brain and coagulates, activates microglia and leads to
RESEARCH NEWS 2019-02-15 Research News Malfunctioning mitochondria accumulate in the Alzheimer’s disease brain. Could they be purged? In the February 11 Nature Neuroscience, researchers led by Vilhelm Bohr at the National Institute on Aging, Baltimore, argue that these defective
RESEARCH NEWS 2019-02-18 Research News Could a dietary supplement marketed directly to consumers moonlight as an effective treatment for ALS? It is within the realm of possibility, according to the results of a small Phase 1 pilot study testing EH301 in people with the disease. E
RESEARCH NEWS 2019-04-05 Research News As researchers are becoming wise to microglial diversity, they may also want to keep their eyes out for varied populations of the true glia of the brain. In the April 1 Nature Neuroscience, Jeffrey Rothstein’s group at Johns Hopkins Universi
RESEARCH NEWS 2018-06-15 Research News Despite years of research on ApoE4, questions remain about exactly how this gene variant raises risk for Alzheimer’s disease. To boot, much of the data to date has come from mouse models and may not reflect human brain biology. Two new paper
RESEARCH NEWS 2018-07-06 Research News Four years ago, researchers made a splash with the first in vitro model of Alzheimer’s pathology. In that advance, dubbed “Alzheimer’s in a dish,” neurons and astrocytes grown in a three-dimensional gel matrix produced amyloid plaques and hy
COMMUNITY NEWS 2018-08-27 Community News The U.S. Senate has voted to allocate more funds to Alzheimer’s research. In an 85–7 vote on August 23, the lawmakers stipulated a 2019 fiscal year budget that, if signed into law, would include $2.34 billion for AD research, topping 2018’s
