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RESEARCH NEWS 2014-08-23 Research News In the August 21 Science, researchers led by Michal Schwartz and Ido Amit, Weizmann Institute of Science, Rehovot, Israel, report that the choroid plexus, the barrier separating the blood and the cerebrospinal fluid, plays a key role in brai
RESEARCH NEWS 2014-08-27 Research News Excess α-synuclein kills neurons, and part of the reason may well be that the protein causes the cells to overdose on calcium, which hyperactivates the phosphatase calcineurin. In the August 13 Proceedings of the National Academy of Sciences
RESEARCH NEWS 2014-08-28 Research News Some amyloid-β accumulates in mitochondria, where it has been blamed for all manner of malfunctions, from respiration problems to wonky organelle morphology. How could one small peptide be responsible for so much mayhem? Researchers think th
RESEARCH NEWS 2014-08-29 Research News Amyloid-β can kill neurons whose cell bodies lie far away, but researchers are unsure how. A study in the August 28 Cell from the lab of Ulrich Hengst, Columbia University, New York, suggests that the peptide triggers local synthesis of a pr
RESEARCH NEWS 2014-08-29 Research News Magnetic resonance imaging detects upper motor neuron damage in people with amyotrophic lateral sclerosis, and the signal correlates with the severity of a patient’s symptoms, according to a small study published in the August PLoS One. Scie
RESEARCH NEWS 2014-08-29 Research News Can magnetic pulses—delivered to the head with a hand-held device— fine-tune brain circuits involved in memory? New research suggests that they can, at least temporarily. In the August 29 Science, researchers led by Joel Voss at Northwestern
RESEARCH NEWS 2014-09-05 Research News Genome-wide association studies point scientists toward chromosome loci that influence disease risk, but for the most part they yield ZIP codes rather than specific genetic addresses, many of them in non-coding regions. “GWAS have undoubtedl
RESEARCH NEWS 2014-09-05 Research News Ever since scientists sequenced the first human genome in 2003, they have tried to finger regulatory influences that dictate when and where a person’s 21,000 or so genes are expressed. To help, the National Human Genome Research Institute (N
RESEARCH NEWS 2014-09-12 Research News In the viral video craze of the summer, millions of people dumping freezing water on their heads generated an unexpected deluge of more than $100 million to support amyotrophic lateral sclerosis charities. The ALS Association took in $112 m
RESEARCH NEWS 2014-09-12 Research News Bacteria have been doing it for millennia. Researchers, on the other hand, have only recently learned how to wield CRISPR—a gene-editing tool that bestows the power to delete, add, or toy with the expression of genes at virtually any site in
RESEARCH NEWS 2014-09-12 Research News CRISPR, a gene-editing technology borrowed from humble bacteria, has taken the biomedical research world by storm. Researchers can use the technique to inactivate genes, add point mutations, or insert entire genes into virtually any spot in
COMMUNITY NEWS 2014-09-12 Community News The Albert and Mary Lasker Foundation announced September 8 that Alim Louis Benabid of Joseph Fournier University in Grenoble, France, and Mahlon DeLong of Emory University School of Medicine in Atlanta will receive the 2014 Lasker-DeBakey
RESEARCH NEWS 2014-09-12 Research News A therapy developed by the Swiss-based pharmaceutical company Novartis could be the next big thing for congestive heart failure, a serious disease that afflicts about 5 million Americans. Called LCZ696, this drug prevented cardiovascular-rel
RESEARCH NEWS 2014-09-12 Research News Are cerebrospinal fluid biomarkers for Alzheimer’s disease ready to branch out from research centers into clinical care? Thus far, high variability of CSF measurements, and lingering doubt as to what an abnormal reading means for a particula
RESEARCH NEWS 2014-09-15 Research News Oversized nucleotide repeat expansions in two genes, ataxin 2 and C9ORF72, boost carriers’ risk for amyotrophic lateral sclerosis, frontotemporal dementia, or a combination of both. The discovery of these two disease genes inspired clinician
