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RESEARCH NEWS 2023-09-27 Research News Variants of TMEM106b are tied to frontotemporal dementia and Alzheimer’s disease, but how the endolysosomal protein provokes pathology is unknown. Perhaps by perturbing myelin, suggest researchers led by Stephen Strittmatter, Yale University
RESEARCH NEWS 2023-09-22 Research News Mutations in the tau gene that cause frontotemporal dementia wreak all manner of neuronal havoc, from endolysosomal traffic jams to mitochondrial distress to a standstill in nucleocytoplasmic transport. How can a single point mutation inflic
RESEARCH NEWS 2023-09-21 Research News With several fluid biomarkers for Alzheimer’s in hand, the search is on for counterparts in Parkinson’s disease and dementia with Lewy bodies (DLB). Four new papers introduce two candidates: DOPA decarboxylase (DDC), the enzyme that converts
RESEARCH NEWS 2023-09-20 Research News Once overlooked, astrocytes are increasingly recognized as star players in Alzheimer’s disease, with recent studies blaming them for feeding into a neurotoxic stew that kills neurons. In the September 7 Nature Metabolism, researchers led by
RESEARCH NEWS 2023-09-19 Research News When they find themselves trapped in an amyloid-ridden mouse brain, transplanted human neurons meet an untimely, necrotic demise. While this had been known before, a new-and-improved xenograft model has unveiled some of the dirty details beh
RESEARCH NEWS 2023-09-14 Research News Physical activity staves off dementia, but does that mean being sedentary makes cognitive decline more likely? Yes, according to David Raichlen, University of Southern California, Los Angeles, and colleagues. In the September 12 JAMA, the sc
RESEARCH NEWS 2023-09-14 Research News A panel of 48 CSF proteins—Aβ or tau not among them—distinguished people with Alzheimer's from controls with 94 percent accuracy, according to a study published September 6 in Science Translational Medicine. Adding classic AD biomarkers
RESEARCH NEWS 2023-09-13 Research News Could aggregated Aβ seeds be passed from one person to another via blood transfusions? In the September 12 JAMA, researchers led by Jingcheng Zhao at Karolinska University Hospital in Solna, Stockholm, raised this alarming specter. In a retr
COMMUNITY NEWS 2023-09-12 Community News Earlier this month, the National Institute on Aging announced a new competition: the Pioneering Research for Early Prediction of Alzheimer’s and Related Dementias EUREKA Challenge, aka PREPARE. The goal? To improve early detection of AD and
RESEARCH NEWS 2023-09-09 Research News Different variants in the gene encoding phospholipase C-γ2—an enzyme expressed in microglia—can either raise the risk of AD, or protect against it. According to a study published September 12 in Immunity, the respective variants shape how mi
RESEARCH NEWS 2023-09-08 Research News In the Alzheimer’s disease brain, synaptic loss correlates with cognitive decline, and is considered a sign of disease progression. But is synaptic loss always bad? Provocative new data from several groups suggest that early in disease, sele
RESEARCH NEWS 2023-09-08 Research News In the blood, lipoproteins ferry cholesterol and other lipids to cells throughout the body. In the cerebrospinal fluid, they may do the same, but because they are 200-fold more dilute there, scientists know little about them. Now, John Melch
RESEARCH NEWS 2023-09-06 Research News Alois Alzheimer reported lipid-filled glia surrounding amyloid plaques in the AD brain. But how and why they appear remains elusive. Now, two bioRxiv preprints blame Aβ. In one, posted June 6, scientists led by Gaurav Chopra of Purdue Univer
RESEARCH NEWS 2023-09-01 Research News Neuronal death is the indisputable endgame of Alzheimer’s disease, but what does the killing, and how? To try to solve the mystery, researchers have staged increasingly complex crime scenes in three-dimensional co-culture systems. Microglia
RESEARCH NEWS 2023-08-31 Research News Some older people accumulate tau in their medial temporal lobes but have no amyloid plaques, a condition called primary age-related tauopathy (PART). Do they eventually develop Alzheimer’s disease? At least not over a span of three years, ac
