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Plasma Proteomics Studies Link Genetic Variants to Phenotypes

RESEARCH NEWS 2023-10-13 Research News GWAS uncover associations between genetic variants and human disease, but they do not reveal how those variants act on the body. Linking genetic polymorphisms to changes in plasma proteins could provide some clues. Three papers in the Octobe

Behold, the Human Brain Like Never Seen Before

RESEARCH NEWS 2023-10-12 Research News Understanding the human brain has entered a new era with the birth of a comprehensive cell atlas. Scientists used single-cell RNA sequencing, epigenetic analyses, and spatial mapping to study millions of brain cells from 100 brain regions, d

Stunning Detail: Single-Cell Studies Chart Genomic Architecture of AD

RESEARCH NEWS 2023-10-07 Research News Why do some people descend into dementia as they age, while others remain sharp? How do genetic variants influence AD pathogenesis? Ditto for the myriad ephemeral states of microglia influence? These are burning questions in AD research thes

Could a Faulty Ubiquitin Trigger Amyloid and Tau Deposits?

RESEARCH NEWS 2023-10-07 Research News Scientists believe that in late-onset Alzheimer’s disease, Aβ clearance slows, causing the protein to accumulate in plaques. In the September 22 Nature Communications, researchers led by Michael Glickman and Yaron Fuchs at the Technion Israe

Acetylation Accelerates Aggregation of 3R, but Not 4R, Tau

RESEARCH NEWS 2023-10-06 Research News Tauopathies are classified by which tau isoform forms fibrils—those with three microtubule-binding domain repeats (3R), those with four (4R), or those with both. What drives one isoform to aggregate over the other? Post-translational modific

Not So Fast—The Brain Has Three Meningeal Membranes After All

RESEARCH NEWS 2023-09-29 Research News Earlier this year, a high-profile Science paper caused a stir with its claim that the brain has a fourth, previously unrecognized, meningeal membrane. Dubbed SLYM and containing Prox1+ cells, this membrane was proposed to divide the subarach

Does Plaque ApoE Summon Microglia to Amyloid?

RESEARCH NEWS 2023-09-29 Research News As resident trash collectors, microglia survey the brain in search of detritus for disposal. How do they recognize the debris? In the case of plaques, a cell-surface receptor might be involved, though not necessarily TREM2. In the September

Spooned by a Fold: MK-6240 Nestles Within Tau Protofilament

RESEARCH NEWS 2023-09-28 Research News In the decade since the first tau PET ligands burst onto the scene, chemists have been tinkering with the compounds to enhance their penchant for pathological tau. A study posted September 22 on bioRxiv reveals just how snugly one of the res

Endolysosomal TMEM106b Regulates Myelin Lipid Metabolism

RESEARCH NEWS 2023-09-27 Research News Variants of TMEM106b are tied to frontotemporal dementia and Alzheimer’s disease, but how the endolysosomal protein provokes pathology is unknown. Perhaps by perturbing myelin, suggest researchers led by Stephen Strittmatter, Yale University

Missing ‘Lnc’? Long Noncoding RNAs Bind Tau, Tame Stress Granules

RESEARCH NEWS 2023-09-22 Research News Mutations in the tau gene that cause frontotemporal dementia wreak all manner of neuronal havoc, from endolysosomal traffic jams to mitochondrial distress to a standstill in nucleocytoplasmic transport. How can a single point mutation inflic

Meet the Two New Biomarker Candidates for Lewy Body Diseases

RESEARCH NEWS 2023-09-21 Research News With several fluid biomarkers for Alzheimer’s in hand, the search is on for counterparts in Parkinson’s disease and dementia with Lewy bodies (DLB). Four new papers introduce two candidates: DOPA decarboxylase (DDC), the enzyme that converts

Astrocyte Receptor Suppresses Neurotoxic Lipids, Preserves Neurons

RESEARCH NEWS 2023-09-20 Research News Once overlooked, astrocytes are increasingly recognized as star players in Alzheimer’s disease, with recent studies blaming them for feeding into a neurotoxic stew that kills neurons. In the September 7 Nature Metabolism, researchers led by

When Faced with Amyloidosis, Human Transplants Die by Necroptosis

RESEARCH NEWS 2023-09-19 Research News When they find themselves trapped in an amyloid-ridden mouse brain, transplanted human neurons meet an untimely, necrotic demise. While this had been known before, a new-and-improved xenograft model has unveiled some of the dirty details beh

Sit Less, Move More to Induce Irisin and Stave Off Dementia

RESEARCH NEWS 2023-09-14 Research News Physical activity staves off dementia, but does that mean being sedentary makes cognitive decline more likely? Yes, according to David Raichlen, University of Southern California, Los Angeles, and colleagues. In the September 12 JAMA, the sc

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