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A Phospho-Tau Plasma Assay for Alzheimer’s?

RESEARCH NEWS 2020-03-31 Research News Researchers stunned the field last summer when they reported that phosphorylated tau turns up in peoples’ plasma decades before they show signs of dementia. The data bore the promise of a blood test for early Alzheimer’s disease—one that is ...

A ‘Perfect Storm’ for Families Grappling with Dementia

COMMUNITY NEWS 2020-03-28 Community News As the COVID-19 pandemic engulfs the globe, it puts extraordinary strain on at-risk groups—very much including people with neurodegenerative disease and their carers. Not only do most people with neurodegenerative diseases fall into the age ...

Coronavirus Takes Its Toll on Alzheimer’s Clinical Studies

COMMUNITY NEWS 2020-03-27 Community News The coronavirus pandemic is upending not only life as we knew it, but Alzheimer’s clinical studies as well. In the United States, Europe, and Australia, most sites have put observational cohort studies on hold, and many have stopped dosing ...

Social Distancing Shutters Alzheimer’s Research

COMMUNITY NEWS 2020-03-27 Community News “Do what you can, with what you have, where you are.” Theodore Roosevelt. Globally the story is the same almost everywhere. Scientists are in lockdown, most staying at home as skeleton crews tend to the most crucial experiments and valuable ...

Dementia Research Institute to Double U.K. Coronavirus Testing

COMMUNITY NEWS 2020-03-24 Community News While science groups worldwide are grappling with the logistics of shutting down to comply with the social distancing required to slow the spread of COVID-19, neurodegenerative disease researchers are asking how they can help. And help they ...

Stress-Associated Protein Modulates γ-Secretase to Make More Aβ

RESEARCH NEWS 2020-03-21 Research News In the March 17 Science Signaling, researchers led by Yong-Keun Jung at Seoul National University, South Korea, reported a new modulator of γ-secretase that appears to preferentially affect cleavage of amyloid precursor protein. Stress ...

Traveling C9ORF72 Dipepides Jam Proteasomes in Neighboring Neurons

RESEARCH NEWS 2020-03-20 Research News Hexanucleotide expansions in the C9ORF72 gene are the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia, but how the dipeptide repeats (DPRs) translated from the expansions incite disease still puzzles ...

Alzheimer’s Gene BIN1 Promotes Synaptic Transmission

RESEARCH NEWS 2020-03-18 Research News BIN1, one of the strongest genetic risk factors for late-onset Alzheimer’s disease, encodes a protein that dabbles in many cellular functions, taking a hand in Aβ production, tau propagation, and microglial function. Now, in the March 10 ...

Plaques, Tangles Throw Off the Brain’s Rhythms

RESEARCH NEWS 2020-03-13 Research News Brain rhythms change their tune in people with Alzheimer’s disease, and they do so to the beat of Aβ and tau, according to a study published in Science Translational Medicine on March 11. Researchers led by Keith Vossel and Srikantan ...

Different CSF Phospho-Taus Match Distinct Changes in Brain Pathology

RESEARCH NEWS 2020-03-13 Research News The phosphorylation of tau in the Alzheimer’s brain is not a binary state. It evolves over time, passing through distinct stages that reflect worsening disease, according to a study in the March 11 Nature Medicine led by Randall Bateman and ...

Without TMEM106B, Lysosomal Traffic Jams Wreak Havoc in Neurons

RESEARCH NEWS 2020-03-11 Research News TMEM106b, a gene carrying risk variants for frontotemporal dementia (FTD), coordinates the steady stream of lysosomal traffic along axons, according to a study published March 10 in Cell Reports. Researchers led by Markus Damme of Christian ...

Paper Alert: Mouse TREM2 Antibody Boosts Microglial Plaque Clean-Up

RESEARCH NEWS 2020-03-10 Research News A new antibody turbocharges TREM2, the most ardent supporter of microglia. In mice, that is. According to a study published March 10 in the EMBO Journal, a monoclonal antibody trained against the mouse microglial receptor prevents shedding ...

Tau Receptor Identified on Cell Surface

CONFERENCE COVERAGE 2020-03-07 Conference Coverage Evidence now seems overwhelming that toxic forms of tau spread from cell to cell, causing the characteristic progression of tauopathies such as Alzheimer’s and frontotemporal dementia. But how does tau get from one cell to another? At ...

Primary Tauopathies Get New PET Ligands

CONFERENCE COVERAGE 2020-03-06 Conference Coverage Scientists studying the non-Alzheimer’s disease tauopathies have struggled to find tracers that will bind the particular forms of tau that predominate in those diseases. At Tau2020, held February 12–13 in Washington, D.C., Gil ...

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