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Studies Point to DNA Difficulties in ALS/FTD

RESEARCH NEWS 2019-02-15 Research News Three studies published this week on the etiology of amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD) spotlight a cell compartment that is often overlooked. They focus squarely on the nucleus, specifically the integrity of ...

Could Disposing of Damaged Mitochondria Treat Alzheimer’s Disease?

RESEARCH NEWS 2019-02-15 Research News Malfunctioning mitochondria accumulate in the Alzheimer’s disease brain. Could they be purged? In the February 11 Nature Neuroscience, researchers led by Vilhelm Bohr at the National Institute on Aging, Baltimore, argue that these defective ...

Clotting Protein from Blood Incites Microglia, and Synapses Die

RESEARCH NEWS 2019-02-08 Research News A damaged and leaky blood-brain barrier contributes to dementia, but just how has not been clear. Previous work implicated the clotting protein fibrinogen, which, when it penetrates the brain and coagulates, activates microglia and leads to ...

Is a Woman’s Brain More Susceptible to Tau Pathology?

RESEARCH NEWS 2019-02-08 Research News Some studies of cerebrospinal fluid biomarkers suggest that women accumulate more tau pathology early in Alzheimer’s disease than do men. In the February 4 JAMA Neurology, researchers led by Rachel Buckley and Reisa Sperling at Massachusetts ...

Panel of Blood Markers Signals Amyloid in Brain

RESEARCH NEWS 2019-02-07 Research News Yet another potential blood test for amyloid pathology has entered the ring. Using mass spectrometry to take an unbiased look at plasma proteins, researchers led by Abdul Hye, King’s College London, found a panel of biomarkers that predicted ...

Cholesteryl Esters Hobble Proteasomes, Increase p-Tau

RESEARCH NEWS 2019-02-07 Research News A cholesterol metabolite boosts accumulation of phosphorylated tau, according to a paper in the January 16 Cell Stem Cell. Researchers led by Lawrence Goldstein at the University of California, San Diego, reported that cholesteryl esters ...

Cancer Treatment Takes Aim at Tauopathy

RESEARCH NEWS 2019-02-05 Research News Three years ago in a high-profile paper, researchers led by Michal Schwartz at the Weizmann Institute of Science in Rehovot, Israel, deployed an immune-boosting approach pioneered for cancer in a mouse model of Alzheimer’s disease. The ...

In Alzheimer’s, Too Little REST Spurs Too Much Neurogenesis

RESEARCH NEWS 2019-02-04 Research News A paper published January 29 in Cell Reports claims that among the earliest changes in sporadic Alzheimer’s disease (SAD) are genetic changes that lead to premature neurogenesis. Scientists led by Bruce Yankner, Harvard Medical School, found ...

ApoE Binds Complement Protein, Keeps Inflammatory Cascade in Check

RESEARCH NEWS 2019-02-01 Research News This story was updated on February 5, 2019. Just when you thought ApoE biology couldn’t get any more complicated, scientists have discovered a new function for this apolipoprotein. According to a January 28 paper in Nature Medicine, ApoE ...

In Pathology Cascade, Microglia Rev Up After Plaques but Before Tangles

RESEARCH NEWS 2019-02-01 Research News Microgliosis goes hand-in-hand with Alzheimer’s disease, but the exact staging remains murky. A neuropathological study in the January 24 Nature Communications now places one type of microglial activation into the AD pathological cascade. ...

Blood Test Granted Breakthrough Status, To Be Tested in Trial

RESEARCH NEWS 2019-02-01 Research News St. Louis-based C2N announced  this week that the Food and Drug Administration has fast-tracked review of its blood test for amyloid pathology, granting it Breakthrough Device designation. This status is reserved for devices that could ...

Roche Pulls Plug on Two Phase 3 Trials of Crenezumab

RESEARCH NEWS 2019-01-31 Research News Yesterday, Roche announced a halt to the Phase 3 CREAD 1 and CREAD 2  trials of the anti-amyloid antibody crenezumab. According to a company press release, an interim analysis found the trial was unlikely to reach its primary endpoint of ...

SPRINT MIND Data Published, Follow-Up Extended

RESEARCH NEWS 2019-01-30 Research News Results of the SPRINT MIND trial were published in the January 28 JAMA Neurology. The data indicate that reducing systolic blood pressure to about 120 mmHg over 3.25 years cut the incidence of mild cognitive impairment by 19 percent in ...

An Antimicrobial Approach to Treating Alzheimer’s?

RESEARCH NEWS 2019-01-28 Research News Do periodontal bacteria cause some cases of Alzheimer’s disease? Scientists at one start-up think so, and their investors are putting their money where their mouths are, moving forward with clinical development of a bacterial protease ...

Dementia: Frailty Hastens It, Physical Activity Wards It Off

RESEARCH NEWS 2019-01-25 Research News How is it that some people can have a brain full of plaques and tangles, yet somehow fend off dementia? By way of explanation, the concept of cognitive reserve tends to come up and now, two new postmortem studies suggest that physical ...

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