IDEAS Finds Small Drop in Hospitalizations, Missing Goal

CONFERENCE COVERAGE 2020-08-01 Conference Coverage Numerous studies have now found that amyloid PET scans can alter a person’s diagnosis and disease management—but do they reduce overall medical costs? According to data from the final phase of the IDEAS study, presented at the virtual ...

Doubling Down on Sequencing Serves up More Alzheimer’s Genes

CONFERENCE COVERAGE 2020-07-31 Conference Coverage The list of rare and common genetic variants that sway a person’s risk of Alzheimer’s disease just got substantially longer, as researchers expanded both the breadth and depth of genomic studies aimed at uncovering the etiology of the ...

Paper Alert: Those PIGs! Spatial Transcriptomics Add Human Data

RESEARCH NEWS 2020-07-30 Research News Far from being innocent bystanders to pathology, amyloid plaques actively stir up trouble by perturbing the brain tissue surrounding them, according to researchers led by Mark Fiers and Bart De Strooper at KU Leuven, Belgium. In a preprint ...

Could Common Vaccines Protect Against Alzheimer’s Disease?

CONFERENCE COVERAGE 2020-07-29 Conference Coverage During a viral pandemic, everything to do with vaccination is au courant. At this week’s virtual Alzheimer’s Association International Conference, two reports drew attention by turning on its head the field’s emerging research trend ...

Plasma p-Tau217 Set to Transform Alzheimer’s Diagnostics

CONFERENCE COVERAGE 2020-07-29 Conference Coverage Suddenly, phospho-tau217 looks to be the most robust plasma biomarker for Alzheimer’s disease yet. That’s the general—and enthusiastic—consensus from two papers and several presentations at this year’s virtual Alzheimer’s Association ...

In APP Knock-In Mice, Spatial Mapping Circuitry Crumbles

RESEARCH NEWS 2020-07-24 Research News People with Alzheimer’s get lost in once-familiar places, often quite early in their disease. A study published July 13 in Neuron helps explain why. Researchers led by Kei Igarashi at the University of California, Irvine, reported that in ...

Neuronal SRPX2 Spoils Microglial Appetite for Synapses

RESEARCH NEWS 2020-07-24 Research News For better or worse, complement proteins tag synapses for elimination by microglia. A paper published July 13 in Nature Neuroscience identifies a neuronal protein that keeps this process in check. Researchers led by Gek-Ming Sia at the ...

Rogue APP Claim Embroiled in Contamination Concerns

RESEARCH NEWS 2020-07-17 Research News It sounded wild at the time: A Nature paper uncovered multiple copies of APP inserted into neuronal genomes, especially among people with sporadic AD. These interlopers purportedly derived from APP mRNA transcripts, which had been reverse ...

Does Huntington’s Disease Begin in the Womb?

RESEARCH NEWS 2020-07-17 Research News Huntington’s disease, like most neurodegenerative conditions, strikes adults. Yet children who carry the infamous causative triple repeat expansion have slightly smaller brains than noncarriers even while they are as functional as their ...

γ-Secretase Spotted Traveling Solo or in Pairs, Not in Big Groups

RESEARCH NEWS 2020-07-10 Research News CryoEM of frozen membranes has revealed its most intimate folds. Biochemistry of tissue extracts says it bundles up with other secretases. But how does γ-secretase, the all-important enzyme that cleaves Aβ42 from its precursor, truly behave ...

PET Tracer PI-2620 Detects 4R Tau Deposits

RESEARCH NEWS 2020-07-10 Research News Tau tracers have invigorated Alzheimer’s research, but they initially proved disappointing for other tauopathies. That is now changing, with at least two tracers, PI-2620 and APN-1607, that appear to bind specifically to the 4R tau deposits ...

Liver Enzyme Levitates with Exercise, Spurs Learning in Old Mice

RESEARCH NEWS 2020-07-10 Research News It’s no longer news that exercise tones the brain as well as the body, keeping cognition sharp with age and lowering the risk of Alzheimer’s disease. Exactly how this works remains murky, however. In today’s Science, researchers led by Saul ...

Biogen Asks FDA To Approve Aducanumab

RESEARCH NEWS 2020-07-08 Research News Biogen announced today that it had submitted a biologics license application to the U.S. Food and Drug Administration for aducanumab, a therapeutic antibody developed to clear amyloid plaques from the brain. The Cambridge, Massachusetts, ...

With IL-33, Neurons Tempt Microglia to Nibble At Synapses

RESEARCH NEWS 2020-07-07 Research News Synaptic connections in the brain are highly plastic, continuously forming and disconnecting to help enshrine new experiences into memories throughout life. A study published in Cell on July 1 describes a mechanism involved. Researchers led ...

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