5467 RESULTS
RESEARCH NEWS 2020-09-25 Research News For carriers of a pathogenic mutation in the progranulin gene, variants in another gene—TMEM106b—strongly influence when, and even if, they will develop frontotemporal dementia. A trio of recent papers, published in August and September in ...
RESEARCH NEWS 2020-09-24 Research News Microglia can help or hinder in Alzheimer’s disease. A protective variant of the microglial gene phospholipase C-γ2 (PLCG2) may shed light on what makes the difference. In the September 11 Molecular Neurodegeneration, researchers led by ...
RESEARCH NEWS 2020-09-18 Research News Under rare circumstances, Aβ seeds can be transferred to people during medical procedures. Researchers have turned up a few cases of tissue transplants or hormones from cadavers triggering amyloidosis in the brains or blood vessels of ...
RESEARCH NEWS 2020-09-18 Research News As Aβ accumulates in a person’s brain during the long preclinical stage of Alzheimer’s disease, deficits in learning emerge prior to impairments in episodic memory, according to a study published in Neurology on September 4. Cognitively ...
RESEARCH NEWS 2020-09-12 Research News Pathogenic mutations within coding regions almost always change protein function. For a missense mutation in the DJ-1 gene that causes Parkinson’s disease, an entirely different mechanism may be at play. According to a study led by led by ...
RESEARCH NEWS 2020-09-11 Research News A combination drug that targets cellular stress nudged, ever so slightly, progression of amyotrophic lateral sclerosis in a Phase 2 trial. Researchers led by Sabrina Paganoni at Massachusetts General Hospital, Boston, reported the findings ...
RESEARCH NEWS 2020-09-09 Research News Different genetic mutations can converge on the same downstream pathology. The C9ORF72 repeat expansion and progranulin haploinsufficiency both trigger the RNA-binding protein TDP-43 to abandon the nucleus and settle in cytoplasm. TDP-43 ...
COMMUNITY NEWS 2020-09-04 Community News When Peter Davies passed away on August 26, the Alzheimer’s research community lost a brilliant mind, and a truly generous human being. Davies died at age 72, after a long battle with cancer. His discoveries paved the way for the first ...
RESEARCH NEWS 2020-09-04 Research News Neurexin proteins lie in the presynapse and pentraxins in the post, and never the twain shall meet. But what if they did? By designing a small protein that binds to both, researchers in Japan, Germany, and the U.K., have created an ...
RESEARCH NEWS 2020-09-03 Research News Neuroinflammation and Aβ deposition are two hallmarks of AD, and now, a study published September 3 in Nature is forging an alluring mechanistic link between them. Researchers led by Yueming Li at Memorial Sloan Kettering Cancer Center in ...
COMMUNITY NEWS 2020-09-01 Community News Trying out a new conference format in this pandemic era, the Alzheimer’s Disease Genetics Global Symposium starts September 1 and will run on demand through much of the month. For three weeks, registrants can view presentations as they ...
RESEARCH NEWS 2020-08-29 Research News Mice fail to model many aspects of Alzheimer’s disease. Could monkeys capture the disease more fully? In a preprint posted to bioRXiv on August 24, researchers led by Takaomi Saido, RIKEN Center for Brain Science, Wako, and Erika Sasaki, ...
RESEARCH NEWS 2020-08-28 Research News For the first time, researchers have solved the molecular structure of LRRK2, a major risk factor for Parkinson’s and autoimmune diseases. Structural biologists at the University of California, San Diego, used innovative methods to provide ...
RESEARCH NEWS 2020-08-28 Research News As a group, women may be more likely than men to develop Alzheimer’s disease, but once they have it, they cope better and live longer. A study published August 26 in Science Translational Medicine credits a second X chromosome with some of ...
RESEARCH NEWS 2020-08-21 Research News Best known for its role in churning out Aβ peptides as the catalytic subunit of γ-secretase, presenilin-1 may also promote digestion of those Aβ peptides within microglia. That is the upshot of a study published August 13 in Molecular ...
