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CONFERENCE COVERAGE 2018-12-04 Conference Coverage Indigenous Australian people opened the 11th International Conference on Frontotemporal Dementia at the International Convention Center, Sydney, November 11–14. Koomurri performers welcomed more than 600 attendees from 37 countries. ...
CONFERENCE COVERAGE 2018-12-02 Conference Coverage Following their transcription from the genome, RNA messages exit the nucleus and enter the cytoplasm, sometimes traveling vast distances before they are finally translated into protein. RNA-binding proteins are helping hands on this ...
CONFERENCE COVERAGE 2018-12-01 Conference Coverage Similar to a newborn human, nascent RNA transcripts need a lot of coddling before they realize their purpose in life (that is, translation into protein). It takes a village of RNA-binding proteins to accomplish this. They see to the ...
CONFERENCE COVERAGE 2018-11-30 Conference Coverage Hexanucleotide expansions in the first intron of the C9ORF72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Scientists entertain several possible explanations for what ...
RESEARCH NEWS 2018-11-30 Research News In the November 21 Neurobiology of Disease, researchers led by Cristiano Corona, Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d’Aosta, Turin, Italy, characterize the ALS-like signs and symptoms seen in pigs that ...
RESEARCH NEWS 2018-11-30 Research News Researchers often do not understand exactly how treatments produce benefits. Take a recent gene therapy for Parkinson’s disease. It was intended to dampen excess activity in the subthalamic nucleus, mimicking the effect of deep brain ...
RESEARCH NEWS 2018-11-29 Research News People take aspirin for pain, fever, and even in hopes of warding off a heart attack. Could this old, over-the-counter pill also help control multiple sclerosis? A November 27 report in Science Signaling suggests as much—in mice. Scientists ...
CONFERENCE COVERAGE 2018-11-27 Conference Coverage As researchers push toward testing Alzheimer’s drugs at presymptomatic stages, the hurdle before them—how to show efficacy and get a drug approved—looks different than before. In its February 2018 draft guidance for industry, the U.S. ...
RESEARCH NEWS 2018-11-27 Research News Progranulin, a microglial protein typically associated with frontotemporal dementia, may also play a role in Alzheimer’s. That’s according to a November 27 paper in the EMBO Journal. Scientists led by Christian Haass, Ludwig-Maximilians ...
RESEARCH NEWS 2018-11-21 Research News Multiple copies of the amyloid precursor gene crop up in adult neurons of the human brain, creating a heterogeneous neuronal landscape in a single person. This is especially true in brains from people with sporadic Alzheimer’s disease, but ...
CONFERENCE COVERAGE 2018-11-20 Conference Coverage To speed up recruitment into Alzheimer’s trials, researchers have created innovative new platforms that establish trial-ready cohorts of people at early disease stages. The farthest along is the European Prevention of Alzheimer’s ...
CONFERENCE COVERAGE 2018-11-20 Conference Coverage This is Part 2 of a two-part story. Click here for Part 1. The highs and lows of diabetes-related therapies were on display at the Clinical Trials on Alzheimer’s Disease Conference, held October 24–27 in Barcelona, Spain. This time ...
CONFERENCE COVERAGE 2018-11-20 Conference Coverage This is Part 1 of a two-part story. Click here for Part 2. As in years past, trial results offered up a mixed bag of goods and duds at the Clinical Trials on Alzheimer’s Disease Conference, held October 24–27 in Barcelona, Spain. In ...
CONFERENCE COVERAGE 2018-11-19 Conference Coverage This past spring, the National Institute on Aging and Alzheimer’s Association proposed a new research framework in an effort to nudge the field toward a biological definition of Alzheimer’s disease (Apr 2018 news). The framework ...
RESEARCH NEWS 2018-11-16 Research News A cell biology study adds evidence that sensory neurons, not just motoneurons, take a direct hit in amyotrophic lateral sclerosis (ALS). Scientists led by Gregorio Valdez, Virginia Tech Carilion Research Institute, Roanoke, report that ...
