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Familial Alzheimer’s Mutations: Different Mechanisms, Same End Result

RESEARCH NEWS 2019-04-12 Research News Though all autosomal-dominant AD mutations lead to Aβ pathology, they do so by disturbing γ-secretase processing of APP in different ways. In the April 12 Molecular Psychiatry, researchers led by Selina Wray of University College London ...

Closing the Book on NSAIDs for Alzheimer’s Prevention

RESEARCH NEWS 2019-04-12 Research News Epidemiological data suggest that non-steroidal anti-inflammatory drugs (NSAIDs) stave off dementia, but multiple clinical trials have failed to bear that out. Now, the most recent and, the authors say, final effort has come up short. In the ...

Results from Verubecestat APECS Trial Published

RESEARCH NEWS 2019-04-11 Research News Results were published today from the APECS trial, a Phase 3 study of the BACE1 inhibitor verubecestat. In the April 11 New England Journal of Medicine, researchers led by Michael Egan, Merck, Kenilworth, New Jersey, reported that dementia ...

Plaques Age Glial Precursors, Stoking Inflammation

RESEARCH NEWS 2019-04-11 Research News A new study adds evidence that Alzheimer’s pathology makes nearby cells senescent. Scientists led by Mark Mattson, National Institute on Aging, Baltimore, report in the April 1 Nature Neuroscience that in both people and animals, ...

Resetting Brain Rhythms Gives Working Memory a Brief Boost

RESEARCH NEWS 2019-04-10 Research News Groups of neurons fire in sync with each other across the brain when it performs a task; however, with age, they fall out of step. In the April 8 Nature Neuroscience, Robert Reinhart and John Nguyen of Boston University reported that out-of ...

Cut Loose, Soluble TREM2 Beckons Microglia to Mop Up Plaques

RESEARCH NEWS 2019-04-05 Research News As if the biological functions of membrane-bound TREM2 weren’t complicated enough, researchers also have to contend with the actions of its freewheeling counterpart, soluble TREM2. In the March 25 Nature Communications, researchers led by ...

Do Tribes of Astrocytes Wage War on Synapses?

RESEARCH NEWS 2019-04-05 Research News As researchers are becoming wise to microglial diversity, they may also want to keep their eyes out for varied populations of the true glia of the brain. In the April 1 Nature Neuroscience, Jeffrey Rothstein’s group at Johns Hopkins ...

CD22 Suppresses Microglial Phagocytosis—A New Therapeutic Target?

RESEARCH NEWS 2019-04-05 Research News Microglia tend to get off-kilter in Alzheimer’s and other neurodegenerative diseases. Now, researchers in Tony Wyss-Coray’s lab at Stanford University believe they have discovered a means of restoring their homeostasis. On April 3 in Nature ...

Results from IDEAS Study Published

RESEARCH NEWS 2019-04-03 Research News Results of the Imaging Dementia–Evidence for Amyloid Scanning study were published April 2 in JAMA. IDEAS tested if amyloid PET affected the management or outcomes of dementia care. As reported previously on Alzforum, physicians changed ...

Compound Stimulates Lysosome, Clears Tau in Human Cells and Mice

RESEARCH NEWS 2019-03-29 Research News In the latest attempt to rid neurons of toxic tau, researchers are trying to harness and improve cells’ own clearance mechanisms. Researchers led by Kenneth Kosik, University of California, Santa Barbara, used a small molecule called ...

FDA Panel Rejects Neuronix Brain Stimulation Device

RESEARCH NEWS 2019-03-27 Research News An advisory panel appointed by the FDA was nearly unanimous in recommending yesterday that Yokneam, Israel-based Neuronix not be allowed to market its neuroAD Therapy System in the U.S. Approved for AD in Europe, Australia, and Israel, the ...

Neurogenesis Tapers In Older Brains, But Plummets in Alzheimer’s

RESEARCH NEWS 2019-03-25 Research News Does Alzheimer’s disease retard the birth of new neurons in the hippocampus? Data from mouse models suggests it might, but evidence from human brain has been lacking. In today’s Nature Medicine, researchers led by María Llorens-Martín at the ...

Unequal: Some Tau Haplotypes Carry More Risk Than Others

RESEARCH NEWS 2019-03-22 Research News Scientists have known for years that the common H1 haplotype of the tau gene MAPT somehow raises a person’s risk of the rare neurodegenerative disorder progressive supranuclear palsy (PSP). It does so by more than fivefold, similar to what ...

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