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PET Diagnosis Poised for Prime Time? FDA Wants Consensus, Better Trials

CONFERENCE COVERAGE 2003-05-06 Conference Coverage Successful radiotracers for positron emission tomography (PET) diagnosis of AD are a mere year or two away, according to leading researchers who met on May 1-2 in New York. The real challenge now will be in convincing the Food and Drug

Role of the Motor in Motor Neuron Diseases

RESEARCH NEWS 2003-05-02 Research News In today's Science, researchers report that mutations in the protein dynein-the motor that drives the transport of large molecules from the synaptic terminal back to the neuron’s cell body-can lead to forms of neurodegeneration reminisc

New Methods to Study Adult Neurogenesis and Progenitor Maturation

RESEARCH NEWS 2003-05-02 Research News Neuronal progenitors are faced with many forks on the road to becoming one of more than 1,000 different neurons found in the human central nervous system. Tracking exactly what pathways progenitors take to become a specific type of neuron ha

Dampening Down Neurotransmission to Sharpen Vision in Aging Monkeys?

RESEARCH NEWS 2003-05-01 Research News Counterintuitive as it may seem, in tomorrow's Science researchers report that the inhibitory neurotransmitter ã-aminobutyric acid (GABA) can temporarily restore age-related losses of visual acuity in monkeys. Audie Leventhal, Universit

Diagnosis of AD—Does Spinal Fluid Hold the Key?

RESEARCH NEWS 2003-04-27 Research News In this week's Journal of the American Medical Association, researchers report a correlation between Alzheimer's disease (AD) and the appearance in the cerebrospinal fluid (CSF) of two proteins thought to play major roles in the pr

Statins Reduce Brain Cholesterol Metabolite

RESEARCH NEWS 2003-04-27 Research News Several anticholesterol drugs, particularly statins, at standard doses can significantly reduce plasma levels of the brain cholesterol degradation product 24S-hydrocholesterol, according to a report in this week's Archives of Neurology.

Alzheimer's Medal Goes to Pioneer in Diffusible Aβ

COMMUNITY NEWS 2003-04-27 Community News Massimo Tabaton of the University of Genoa, Italy, has been awarded this year's Alzheimer's Medal. The award is presented annually by the associate editors of the Journal of Alzheimer's Disease "for the best article publ

Tau and α-synuclein at the Nexus of Alzheimer's and Parkinson's

RESEARCH NEWS 2003-04-24 Research News There is growing interest in the overlap among Alzheimer's disease, Parkinson's disease, and less common synucleinopathies and tauopathies that can share features of both diseases. Two current papers looking at different levels of

Amyloid Oligomer Antibody—One Size Fits All?

RESEARCH NEWS 2003-04-18 Research News Like good cholesterol and bad cholesterol, the Alzheimer's community has realized that there may also be good Aβ and bad Aβ. What if an antibody was developed to target only the latter? A tall order, yet scientists from the University o

Adult Stem Cells Target Inflammation, Replace Cells in MS Model

RESEARCH NEWS 2003-04-17 Research News Stem cells injected into the cerebral ventricles-or even injected intravenously-find their way to sites of inflammation in an animal model of multiple sclerosis (MS), according to a report in today’s Nature. Once there, they replace the dama

AD Cell Cycle Reentry—Early Rather Than Late

RESEARCH NEWS 2003-04-16 Research News What happens when the protein machinery that drives the cell division cycle gets activated in non-dividing cells such as neurons? The cells will most likely die. Recent evidence suggests that just this type of scenario plays out in the brain

Genes and Longevity—Can One Base Pair Make a Difference?

RESEARCH NEWS 2003-04-14 Research News In this month's Journal of Medical Genetics, a group of Italian researchers propose that there is a link between longevity and a single nucleotide polymorphism (SNP) in the promoter for the antiinflammatory cytokine interleukin-10 (IL-1

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