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RESEARCH NEWS 1999-10-21 Research News According to a report in tomorrow's Science, researchers have uncovered a strong candidate for β-secretase, the mystery enzyme that cleaves APP and allows Aβ to be formed in subsequent cleavages. Martin Cintron, Robert Vassar, Brian ...

Toxic Protofibrillar Aβ

RESEARCH NEWS 1999-10-15 Research News From today's Journal of Neuroscience comes evidence that intermediate Aβ species could be damaging neurons. Dean Hartley, Dennis Selkoe, and their colleagues report that so-called "protofibrillar" Aβ (oligomers intermediate ...

The APPsw Mouse Links ApoE to Damaged Neurons

RESEARCH NEWS 1999-10-12 Research News Further evidence that ApoE is needed for deposition of the fibrillar form of Aβ in plaques was presented today at the American Neurological Association's annual meeting in Seattle today. David Holtzman and his colleagues at Washington ...

Familial Dementia Linked to Neuroserpin Aggregation

RESEARCH NEWS 1999-09-22 Research News Protein misprocessing and aggregation have been observed in many neurodegenerative diseases, including Alzheimer’s, spongiform encephalopathies, Huntington’s, Parkinson’s and FTDP-17, but it has been difficult to untangle the causal ...

Can Age-Related Memory Decline Be Reversed?

RESEARCH NEWS 1999-09-22 Research News Writing in the current Nature Neuroscience, Heather Cameron and Ronald D.G. McKay report that they were able to boost the rate of neurogenesis in the hippocampus of aging rats by lowering corticosteroid levels. The results support the ...

APP Has a Role in Synaptic Development

RESEARCH NEWS 1999-09-15 Research News In today's Journal of Neuroscience, Vivian Budnik, Laura Torroja, and their colleagues at the University of Massachusetts, Amherst, and Brandeis University, Massachusetts, provide evidence that under normal circumstances, APP is a ...

How to Misfold a Prion Protein

RESEARCH NEWS 1999-09-13 Research News In the current Nature Cell Biology, Susan Lindquis and Jiang Ma of the Howard Hughes Institute at the University of Chicago report that they were able to produce abnormal prion protein (PrP) conformations from normal PrP, apparently by ...

Aβ and Tau Accumulation in an Animal Model of Brain Trauma

RESEARCH NEWS 1999-08-31 Research News Douglas Smith and his colleagues at the University of Pennsylvania may have filled a gap in research on long-term, neurodegeneration sequelae of brain injuries by showing Aβ and tau production in an animal model of brain trauma. Their ...

TNF-α Reveals Another Deadly Trick

RESEARCH NEWS 1999-08-26 Research News If the inflammatory cytokine tumor necrosis factor α (TNF-α) is at work in Alzheimer's disease, it may not be relying on its well-described, directly apoptotic mechanism to cause problems, according to a report by Keith W. Kelley and ...

AD Mouse Model with Whole APP and PS-1 Genes

RESEARCH NEWS 1999-07-29 Research News In the August issue of Nature Neuroscience, Bruce Lamb and his associates at Case Western report that they have transferred complete copies of genes for mutant human APP and PS-1 into mice that subsequently produce high levels of Aβ and ...

DNA Damage Surveillance after Head Injury

RESEARCH NEWS 1999-07-28 Research News Various recent studies have reported a link between head trauma and and an increased risk of Alzheimer's disease, but why this might be has been a matter of speculation. In this month’s Journal of Neurochemistry, Tracy McIntosh, ...

Vaccinating Against Plaques

RESEARCH NEWS 1999-07-07 Research News Findings reported in tomorrow’s issue of Nature raise the tantalizing possibility of using vaccination to prevent or ameliorate Alzheimer’s disease. In the study, by Dale Schenk and colleagues at Elan Pharmaceuticals, PDAPP transgenic mice ...

For Lack of a Stop Codon

RESEARCH NEWS 1999-06-23 Research News In tomorrow's issue of Nature, Jorge Ghiso and colleagues at New York University, and coworkers at the National Hospital for Neurology and Neurosurgery in London, report that they have found the gene mutation that produces the amyloid ...

PIN1 Restores Phosphorylated Tau Function

RESEARCH NEWS 1999-06-23 Research News In tomorrow’s issue of Nature (pp. 784-788), Kun Ping Lu of Harvard Medical School and colleagues report that an enzyme, prolyl isomerase Pin1, binds to phosphorylated tau from Alzheimer’s patients and restores tau’s ability to bind to ...

Novel APP-p53 Interaction Found

RESEARCH NEWS 1999-06-22 Research News Neurons taken from the brains of deceased Alzheimer's patients exhibit markers for apoptosis, but little is known about what induces the expression of apoptotic genes. In today’s proceedings of the National Academy of Science, a ...

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