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Soc for Neuroscience Ann Mtg: Reduced Cholesterol Levels Inhibit Aβ

CONFERENCE COVERAGE 1999-10-25 Conference Coverage Using primary hippocampal neurons transfected with APP by means of the Semliki-forest-virus expression system Christine Bergmann (319.2) demonstrated that lovastatin (which inhibits de novo cholesterol synthesis) and methyl-b ...

Society for Neuroscience Annual Meeting: Intraneuronal Aβ

CONFERENCE COVERAGE 1999-10-25 Conference Coverage Until very recently, Aβ accumulation and aggregation were thought to be exclusively extracellular phenomena. However, a number of abstracts presented at this meeting (see 120.10 and 720.10) suggest that this notion must be revisited. ...

Society for Neuroscience Annual Meeting: DIGs—a Site of Aβ?

CONFERENCE COVERAGE 1999-10-25 Conference Coverage Kawarabayashi (319.10) presented compelling data for a time-dependent accumulation of Aβ in the detergent-insoluble glycolipid enriched membrane domains (DIGs) of Tg2576 mouse brain. He also showed that Aβ accumulated in DIGs from ...

Society for Neuroscience Annual Meeting: The TGN—Where It's Happening?

CONFERENCE COVERAGE 1999-10-25 Conference Coverage In an exhaustive study, Iwata (240.1) presented evidence that the trans Golgi network was the major site of Aβ42 production in both neural and non-neural cells. Cos-1 and N2a cells were transfected with C100 bearing retention signals ...

Society for Neuroscience Annual Meeting: TACE, TAPI, and ADAM10

CONFERENCE COVERAGE 1999-10-25 Conference Coverage The mechanisms of regulated α-secretase cleavage were thoroughly examined in two excellent companion posters from Virginia Lee’s lab (240.2, 240.3). The authors demonstrated that TNFalpha converting enzyme (TACE) knockout mice show ...

Society for Neuroscience Annual Meeting: Endocrepsin is BACE

CONFERENCE COVERAGE 1999-10-25 Conference Coverage At times the scene around this poster (240.11) was more like a football scrimmage or a rugby scrum than the normally genteel atmosphere associated with a scientific event. By the time I made my way to within sight of the poster, the ...

Soc for Neuroscience Ann Mtg: Proteasome Inhibition Boosts Aβ

CONFERENCE COVERAGE 1999-10-25 Conference Coverage Janet Johnston (240.16) presented a detailed study of the effect of proteasome and prolendopeptidase (PEP) inhibitors on Aβ production by SH SY 5Y human neuroblastoma cells stably transfected with SPA4CT (C99). Both the proteasome and ...

Society for Neuroscience Annual Meeting: APP Binds to Fibrillar Aβ

CONFERENCE COVERAGE 1999-10-24 Conference Coverage Treatment of human cerebovascular smooth muscle (HCSM) cells with Aβ1-42 or AβQ22 (a mutant associated with hereditary cerebral hemorrhage with amyloidosis-Dutch type) leads to the formation of amyloid fibrils on the surface of HCSM ...

Society for Neuroscience Annual Meeting: β-Secretase Further Confirmed

CONFERENCE COVERAGE 1999-10-24 Conference Coverage Sukanto Sinha, departing from his abstract (122.1), described the purification and partial characterization of a novel 501 amino acid long aspartyl protease. The data were entirely consistent with the β-secretase activities reported by ...

Society for Neuroscience Annual Meeting: Another APP Secretase?

CONFERENCE COVERAGE 1999-10-24 Conference Coverage Just when it appeared as though the mechanisms of the proteolytic processing of APP were finally becoming apparent, Andreas Weidemann presented an elegant study demonstrating the existence of a different processing event (122.2). Using ...

Soc for Neuroscience Ann Mtg: One γ-Secretase, Two Different Activities?

CONFERENCE COVERAGE 1999-10-24 Conference Coverage Using difluoroketone peptidomimetics previously shown to reversibly inhibit γ-secretase activity in CHO cells, Michael Wolfe reported that increasing the bulkiness of the P1 substituent of these compounds increased their potency, thus, ...

Soc for Neuroscience Ann Mtg: APP and Intracellular Aβ Balance Critical

CONFERENCE COVERAGE 1999-10-24 Conference Coverage Recent studies have demonstrated that wild-type APP can protect against p53 mediated apoptosis, whereas FAD mutant APP (FADAPP) cannot. N3 rat neuroblastoma cells which are deficient in APP were transfected with wtAPP or FADAPP and ...

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