Aging and Pathology Interacting in the Cholinergic System

RESEARCH NEWS 1999-06-08 Research News The "cholinergic hypothesis" of cognition places emphasis on the role of cholinergic neurons in the basal forebrain and their projections to cortical areas. This hypothesis is based to a large extent on findings that this system is ...

A Note of Caution about COX-2 Inhibitors

RESEARCH NEWS 1999-06-01 Research News Hopes have been raised that drugs which inhibit the proinflammatory COX-2 enzyme could be effective in treating rheumatoid arthritis and perhaps also Alzheimer's disease, which many scientists think is exacerbated by inflammatory ...

The A2M Deletion, Revisited

RESEARCH NEWS 1999-05-06 Research News Last year Deborah Blacker, Rudolph Tanzi and their colleagues reported finding a strong association between a deletion of exon 18 in the gene for α2 macroglobulin (A2M) and Alzheimer's disease. The odds ratio was 3.56, comparable to the ...

Biochemical Mechanisms of Long-Term Memory

RESEARCH NEWS 1999-05-03 Research News Evidence from several sources suggests that the dorsal hippocampus is critical for the formation and storage of spatial information. In the long term, such information is believed to be transferred to the neocortex for storage. While it is ...

Of Presenilins and Armadillos

RESEARCH NEWS 1999-04-30 Research News The armadillo gene-so named because its mutated form in fruit flies produces a phenotype with short spiky hairs, reminiscent of those on the armadillo-codes for a protein that is a homologue of the human β-catenin. These proteins and other, ...

Vitamin E: More Than an Antioxidant?

RESEARCH NEWS 1999-04-28 Research News Atherosclerotic processes are drawing the attention of some Alzheimer's researchers who point to a number of links between atherosclerotic disease and Alzheimer's disease. It is only natural then, that vitamin E, a hot topic in the ...

Can Functional MRI Predict Alzheimer's Disease?

RESEARCH NEWS 1999-04-23 Research News At the American Academy of Neurology meeting in Toronto, Scott Small and colleagues presented data suggesting that fMRI can distinguish early AD-related memory decline from other sources of memory decline. Citing evidence that entorhinal ...

More Clues in the Case, but γ-Secretase Remains at Large

RESEARCH NEWS 1999-04-15 Research News In the search for the elusive γ-secretase that cleaves β-amyloid precursor protein (APP), much attention has been paid to the protein Notch, which is critical in developmental pathways and has recently been found to be important in immune ...

Watching Enzymes at Work

RESEARCH NEWS 1999-04-09 Research News Three-dimensional images of enzymes at work in cells? This is the promise of a new advance in microscopy called fluorescence lifetime imaging microscopy (FLIM). Philippe Bastiaens and Anthony Squire at the Imperial Cancer Research Fund in ...

Making Dirty RNA from Clean DNA

RESEARCH NEWS 1999-04-05 Research News Fred Van Leeuwen and his colleagues reported last year that some neurons in Alzheimer's patients contain mutant RNA coding for APP and ubiquitin, despite the fact that the DNA from which the RNA had been transcribed was not mutated. By ...

More Details to the β-catenin Picture

RESEARCH NEWS 1999-04-01 Research News β-catenin, a protein that regulates transcription, has drawn attention in Alzheimer's research because it interacts with PS1 and PS2. It was also recently found that AD patients with the PS1 mutation have markedly reduced β-catenin in ...

Abnormal Motion Processing in AD

RESEARCH NEWS 1999-03-22 Research News It has long been assumed that the reason Alzheimer patients tend to get lost is because of memory failure and confusion. But a new study appearing in tomorow’s issue of Neurology suggests that impaired processing of visual information may ...

Prion Soup

RESEARCH NEWS 1999-03-19 Research News Researchers in the U.K. have created conditions inside a test tube in which human prion protein can flip back and forth between normal forms and abnormal forms associated with neurodegenerative disease. In its normal form, prion protein is ...

Human ApoE Slows Plaque Deposition in Tg Mice

RESEARCH NEWS 1999-03-18 Research News Ever since the ApoE4 allele was identified as a risk factor in late-onset Alzheimer's, researchers have speculated that ApoE interacts with β-amyloid. Several years ago, Kelly Bales and colleagues at Lilly Research Laboratories ...

June Kinoshita Interviews John Hardy

INTERVIEWS 1999-03-15 Interviews ARF: What is the primary hypothesis that guides your laboratory? JH: Overall the theme of the lab is to use genetics to find what causes disease and to model the disease in cells and animals. With respect to AD, we believe that that approach ...

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