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June Kinoshita Interviews John Hardy

INTERVIEWS 1999-03-15 Interviews ARF: What is the primary hypothesis that guides your laboratory? JH: Overall the theme of the lab is to use genetics to find what causes disease and to model the disease in cells and animals. With respect to AD, we believe that that approach ...

Major Early Intervention Study Launched

RESEARCH NEWS 1999-03-15 Research News The University of California, San Diego, Alzheimer's Disease Cooperative Study Center is launching a $22 million study to determine whether medical intervention in individuals with mild cognitive impairment (MCI), characterized ...

Chlamydia-Heart Disease Link Found

RESEARCH NEWS 1999-02-26 Research News In the mid-1980s, Finnish researchers reported that 68 percent of heart attack patients and 50 percent of those with coronary heart disease had antibodies to the bacterium Chlamydia pneumoniae, as compared to 17 percent of healthy controls. ...

Computer Simulation Captures Protein Misfolding

RESEARCH NEWS 1999-02-25 Research News Scientists at Sandia National Laboratories and M.I.T. have created the first computer simulation that successfully models how protein misfolding can occur. Protein misfolding is theorized to turn normally benign proteins into toxic ...

Insight Into Neuronal Asymmetry

RESEARCH NEWS 1999-02-24 Research News Neurons are highly polarized cells, with certain proteins within them clearly restricted to specific regions of the plasma membrane. Yet they lack any obvious barriers to free protein diffusion that could explain this asymmetric distribution ...

LTP Deficits Seen in Hsiao Mice

RESEARCH NEWS 1999-02-22 Research News Several years ago, Karen Hsiao and colleagues at the University of Minnesota reported that mice containing an FAD mutant form of the human amyloid precursor protein (APP) are impaired in their ability to learn. These mice, however, do not ...

ApoE4 Affects Recovery from Head Injury

RESEARCH NEWS 1999-01-29 Research News The E4 gene variant of apolipoprotein E (ApoE) confers an increased risk of developing Alzheimer’s disease, but the mechanisms by which it does so are not understood. ApoE plays a role in transporting fatty molecules to cell membranes, and ...

Keith A. Crutcher Interviews Rachael Neve

INTERVIEWS 1999-01-26 Interviews ARF: What’s the primary hypothesis that guides your lab group? RN: We’ve said for many years that we think that the carboxy terminal fragment of APP, that we call C100, which would result from cleavage at the N-terminus of the A-beta sequence, ...

Brian J. Cummings Interviews Paul Coleman

INTERVIEWS 1999-01-18 Interviews ARF: What is the primary hypothesis that guides your laboratory? PC: The primary hypothesis that guides my laboratory shifts from time to time as we and other people get more data; but the primary hypothesis in the lab now is that a cell in AD ...

Aileen Anderson Interviews Dennis Selkoe

INTERVIEWS 1999-01-08 Interviews ARF: What is the primary hypothesis that drives your lab group? DS: The primary hypothesis is that a chronic imbalance in the production versus the clearance of Aβ leading to a gradual rise in its steady state levels in brain tissue is the ...

Brian J. Cummings Interviews Hungtington Potter

INTERVIEWS 1998-12-22 Interviews HP: One of the few things about Alzheimer's disease on which everyone basically agrees is that it starts 20 or 30 years before the first symptoms. That means, when we look in an AD brain, we are looking at the very last stages of the ...

Keith A. Crutcher Interviews John Trojanowski

INTERVIEWS 1998-12-15 Interviews ARF: I appreciate your taking the time to talk to me. JT: I am pleased to do this, since, although my major focus as a biomedical researcher is to try to unravel the causes and mechanisms of neurodegenerative disorders such as Alzheimer's ...

American Society for Cell Biology 38th Ann Mtg: Chaperone Clings to Aβ

CONFERENCE COVERAGE 1998-12-12 Conference Coverage Holtzman et al. (Abstract 612) reported that 95 percent of immunoreactive β-amyloid in human cerebral spinal fluid is bound to the ER chaperone Erp57. Anti-Erp57 and anti-Aβ antibodies were found to react with an approximately 62 kDα ...

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