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Gene Locus Found for Schizophrenia Risk

RESEARCH NEWS 1998-09-03 Research News A 15-year study involving more than 100 families and 1,000 individuals has provided the first strong evidence of genetic susceptiblity to schizophrenia, within a stretch of chormosome 13. According to the international team, led by Ann ...

Yin and Yang of Nerve Cell Growth

RESEARCH NEWS 1998-09-03 Research News The growing tips, or growth cones, of neurons are confronted with a chemical cacophany of growth-guiding cues. How do they know which ones to heed? In an article appearing in Science (4 September issue), H.-J. Song and colleagues report that ...

Epilepsy Drugs Effective for Agitation in AD

RESEARCH NEWS 1998-09-02 Research News For many families caring for an Alzheimer's patient, it is not the memory impairment per se that drives them to place their loved one in a nursing home, so much as the agitation, aggression and even violence that demented patients ...

Stress Hormones Impair Recollection

RESEARCH NEWS 1998-08-20 Research News Stress and glucocorticoids (hormones produced in response to stress) are known to impair the acquisition and storage of new information. But stress also hinders the ability to recall memories, according to a study published by Benno ...

Membrane Rafts Revealed

RESEARCH NEWS 1998-08-20 Research News It has been theorized that cell membranes contain stable regions consisting of glycolipids and cholesterol. They are called detergent-insoluble glycolipid-enriched membrane domains (DIGs), or, more picturesquely, "rafts." These ...

Resisting Apoptosis

RESEARCH NEWS 1998-08-14 Research News Transcription factors of the nuclear factor-kB/rel (NF-kB) family may be important in cell survival by regulating unidentified, antiapoptotic genes. One such gene that protects cells from apoptosis induced by Fas or tumor necrosis factor ...

Cholinergic Switching

RESEARCH NEWS 1998-08-14 Research News Acetylcholine has different effects on the excitability of different neuronal types, according to work by Xiang, et al, published in today's Science. The researchers examined two subtypes of interneurons in layer V of rat visual cortex. ...

More Clues to Diet and Aging

RESEARCH NEWS 1998-08-14 Research News Maybe it is time to give up steak in order to live longer—at least if you are a fruit fly. According to a study published today in Science, a diet of sugar keeps flies in a metabolic "waiting mode," in which both reproduction and ...

Enzyme Affects Aging Rate

RESEARCH NEWS 1998-08-13 Research News An enzyme in Caenorhabditis elegans affects the rate at which the dainty worms age, by modulating the cellular response to oxidative stress. In today's Nature, Naoaki Ishii and his colleagues at the Tokai University School of Medicine, ...

Sixth Int. Conference on AD: Search for Late-Onset AD Genes

CONFERENCE COVERAGE 1998-07-22 Conference Coverage Note: This article was revised on 10 August, 1998, to accommodate some factual corrections. See also R. Tanzi's comment, appended below. 22 July 1998. A study published last year by Margaret Pericak-Vance et al. (JAMA 1997;278) ...

Sixth Int. Conference on AD: Scientists Smitten by Mad Tau Disease

CONFERENCE COVERAGE 1998-07-22 Conference Coverage A new epidemic of "mad tau disease" swept Amsterdam at the workshop on Hereditary Fronto-Temporal Dementia and Pick's disease. Fronto-temporal dementia and Parkinsonism linked to chromosome 17 (FTDP-17) has been linked ...

Sixth Int. Conference on AD: Fibril-busting Mystery Herb

CONFERENCE COVERAGE 1998-07-22 Conference Coverage While a number of drug companies have been pumping big bucks into creating novel molecules capable of inhibiting formation of Aβ fibrils, along comes Alan Snow and his colleagues at the University of Washington and his Seattle-based ...

Sixth Int. Conference on AD: Presenilin-binding Proteins Abound

CONFERENCE COVERAGE 1998-07-22 Conference Coverage Because presenilin was discovered in positional cloning experiments involving large familial Alzheimer's disease kindreds, there were no previous data concerning its biological function. As a result, many groups have used a ...

Sixth Int. Conference on AD: Aging Astrocytes: A Role in AD?

CONFERENCE COVERAGE 1998-07-22 Conference Coverage Yamaguchi (Abstract 1245) presented his theory that very diffuse plaques within nondemented individuals are cleared by astrocytic phagocytosis. He showed many examples of very diffuse Aβ-positive staining within the brains of 40-50 ...

Sixth Int. Conference on AD: Development of Aβ Peptide Inhibitors

CONFERENCE COVERAGE 1998-07-21 Conference Coverage If you came to Amsterdam hoping to hear a lot of new data on Aβ peptide inhibitors, you might have learned more by window shopping in the red-light district. This doesn't mean that the session was without merit. Barbara Cordell ...

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