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Aβ Primes an Inflammatory Pump

RESEARCH NEWS 1999-12-17 Research News A paper in today's Science offers a candidate pathway for inflammatory processes in Alzheimer's disease; the pathway uses the CD40 receptor on microglia and is upregulated by Aβ. Michael Mullan, Jun Tan, and colleagues at the ...

Toward a Unified Prion Theory

RESEARCH NEWS 1999-12-16 Research News The case against the prion appears to solidifying. A report in today's Nature shows that prion forms found in apparently anomalous prion diseases-those that do not feature the abnormally folded prion protein (PrP[Sc])-are likely to ...

Depression Symptoms May Reflect Alzheimer's Pathology

RESEARCH NEWS 1999-12-07 Research News A study in this month's Neurology suggests that depression symptoms seen in early Alzheimer's are related to AD pathology, rather than being a response to memory loss and other Alzheimer's symptoms, or a risk factor that ...

Stem Cells Restore Some Spinal Cord Function

RESEARCH NEWS 1999-12-03 Research News In the political arena, there is almost daily rhetoric about the use of fetal and embryonic tissue in research. Meanwhile, in the laboratory, researchers continue to produce results certain to keep those issues on the front burner. A ...

Gathering at the β-Secretase Corral

RESEARCH NEWS 1999-12-02 Research News The October report in Science by Vassar and colleagues idetifying β-secretase, (see below) has now been followed up by three more reports this month identifying the BACE enzyme (or ASP2, as it has been termed by two of the groups)-one in the ...

More Than One Path to Nitric Oxide Damage

RESEARCH NEWS 1999-12-01 Research News A report in this month's Nature Medicine adds detail, and complexity, to the role of nitric oxide in the neurodegeneration of Parkinson's disease. Serge Przedborski, Gabriel Liberatore, and their collaborators at Columbia, Johns ...

Society for Neuroscience Annual Meeting, Miami: Tau Update

CONFERENCE COVERAGE 1999-11-29 Conference Coverage Toward a neurofibrillary degeneration animal model, Michael Vitek's group (317.1) reported on their tau knockouts. Homozygous mice demonstrated the lack of tau at both mRNA and protein levels. Embryos (-/-) were smaller than wt ...

Fetal Cell Transplants Do Work in Parkinson's

RESEARCH NEWS 1999-11-22 Research News Ten years after a fetal cell transplant, a Parkinson's patient's graft is still delivering dopamine to postsynaptic cells, according to a study appearing in the December issue of Nature Neuroscience. This unprecedented in vivo ...

Presenilin-1 Interferes with Protein Folding

RESEARCH NEWS 1999-11-03 Research News A report in the current Nature Cell Biology describes a mechanism by which presenilin-1 (PS-1) mutations can interfere with protein folding. Kazunori Imaizumi of Osaka University and colleagues suggest that this process underlies ...

Society for Neuroscience Annual Meeting: α-Synuclein: A Review

CONFERENCE COVERAGE 1999-11-03 Conference Coverage Hashimoto, Masliah and colleagues (27.14) reported that cytochrome C stimulates α-synuclein aggregration in vitro and that cytochrome C can be observed in Lewy bodies, in postmortem brain tissue. Whether cytochrome C actually plays a ...

Society for Neuroscience Annual Meeting: Presenilins: An Overview

CONFERENCE COVERAGE 1999-11-01 Conference Coverage Research on presenilins presented at this year's meeting centered around two major questions: 1) What is the role of presenilins in Aβ production and APP processing, and 2) what are the other biological actions of presenilins? A ...

Society for Neuroscience Annual Meeting: Be Wise—Immunize!

CONFERENCE COVERAGE 1999-10-26 Conference Coverage In the relatively short time allotted, Dale Schenk (519.5) managed to describe most of the data from his group’s recent Nature paper (Nature 1999;400:173-177), and a little more. Schenk demonstrated that Aβ immunization of young (six ...

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