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Chris Weihl Interviews Marsel Mesulam

INTERVIEWS 2000-04-07 Interviews ARF: Outline for us what you think are the steps lead to AD pathogenesis? What role do beta amyloid and tau play in AD? Are they related or independent events? MM: Amyloid plaques (AP) and neurofibrillary tangles (NFT) are the two diagnostic ...

Chlamydia Update

RESEARCH NEWS 2000-04-07 Research News Researchers from the Medical University of Lubeck in Germany say that they have failed to replicate the tantalizing evidence from a study published two years ago that found Chlamydia in almost all the Alzheimer's brains examined. The ...

Receptor Miscegenation

RESEARCH NEWS 2000-04-06 Research News Conventional wisdom has it that each member of the large G protein-coupled receptor (GPCR) family pairs up exclusively with another of its own kind. But a new study in tomorrow's Science reports that two different GPCRs, mediating the ...

New Study Correlates Aβ Levels to Degree of Dementia

RESEARCH NEWS 2000-04-05 Research News A central controversy in the Alzheimer's field has been the issue of whether amyloid plaques, comprising primarily Aβ peptide, correlate with the severity of dementia. Inconsistent findings on this point have fueled arguments over the ...

"Parkinson's" in a Transgenic Drosophila

RESEARCH NEWS 2000-03-22 Research News Mel Feany and Welcome Bender of Harvard Medical School have succeeded in creating a transgenic Drosophila melanogaster model of Parkinson's, and surprisingly, have demonstrated that the flies feature all the hallmarks of the human ...

Genes Against Polyglutamine Toxicity

RESEARCH NEWS 2000-03-10 Research News Kazemi-Esfarjani and Benzer of California Institute of Technology report in today's Science the discovery of two genes that protect against eye degeneration resulting from aggregation of polyglutamines in Drosophila. Polyglutamine ...

Cleaning up Aβ

RESEARCH NEWS 2000-03-07 Research News Insulin-degrading enzyme (IDE) plays a role in breaking down Aβ outside of neurons, report Dennis Selkoe, Konstantinos Vekrellis, and their colleagues at Harvard in the March 1 issue of the Journal of Neuroscience. The finding highlights ...

Another AD Link to Inflammatory Processes

RESEARCH NEWS 2000-03-01 Research News For more than a decade, a case has been building for the involvement of inflammatory processes in the pathogenesis of Alzheimer's disease. Now researchers say they have found definitive evidence that implicates the inflammatory cytokine ...

MRI Captures Gene Expression

RESEARCH NEWS 2000-03-01 Research News A team led by Thomas Meade at the California Institute of Technology has developed an MRI contrast agent that is activated only in the presence of a target gene, according to a report in the March issue of Nature Biotechnology. Unlike ...

New Memory Cells from the Hippocampus?

RESEARCH NEWS 2000-02-29 Research News Circumstantial evidence has accumulated over the last decade that there are pluripotent stem cells in the hippocampus of humans and other animals. Much hope has been attached to these heretofore elusive cells because they might be induced to ...

Down's Syndrome Mouse Model Shows Facial Deformities

RESEARCH NEWS 2000-02-23 Research News The Ts65Dn mouse developed at the Jackson Laboratory in Bar Harbor, Maine, has the signature skull and facial deformities of Down's syndrome, strengthening its case as a model for the human syndrome, according to report at the recent ...

Estrogen Does Not Affect AD Progression

RESEARCH NEWS 2000-02-23 Research News Previous studies have shown that women who take estrogen reduce their risk of developing Alzheimer’s disease. But can estrogen also benefit women who already have been diagnosed with the disease? Apparently not, according to a study by a ...

Making Do Without NMDA Receptors

RESEARCH NEWS 2000-02-21 Research News Memory deficits due to NMDA receptor loss in the hippocampus can be overcome by enriched environments, according to a report from Joe Tsien and his Princeton colleagues in the March issue of Nature Neuroscience. Tsien and others had ...

α-Synuclein Transgenic Mice Show Parkinson-like Pathology

RESEARCH NEWS 2000-02-17 Research News Several neurodegenerative diseases, including Alzheimer's, Parkinson's and Lewy body disease, are characterized by abnormal neuronal inclusions of α-synuclein, one of the brain's synaptic proteins. Suspicion that this protein ...

How Does Calorie Restriction Extend Life?

RESEARCH NEWS 2000-02-16 Research News One part of the answer to this question may involve the yeast nuclear protein Sir2, according to a study in tommorow's issue of Nature. Leonard Guarente, Shin-ichiro Imai, and their coworkers at MIT say the protein, which extends the ...

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