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World Alzheimer Conference 2000: Synuclein Update

CONFERENCE COVERAGE 2000-07-28 Conference Coverage Reported by Benjamin Wolozin, Loyola University Medical Center www.meddean.luc.edu/lumen/DeptWebs/pharm/wolozin.htm Increasing attention has focused on the role of synucleins in neurodegeneration. α-synuclein was originally cloned by ...

Imaging Plaques in AD Patients

RESEARCH NEWS 2000-07-27 Research News Joseph F. Poduslo and colleagues at Mayo Clinic report in the August issue of Nature Biotechnology (pp. 868-872) on a technique for imaging Aβ deposits in living brain. The approach may allow an earlier diagnosis of Alzheimer's disease, ...

NFTs in Mice

RESEARCH NEWS 2000-07-27 Research News Mice carrying the P301 mutation in tau, which causes human frontotemporal dementia, develop neurofibrillary pathology with features mimicking those of human tauopathies, report scientists at Mayo Clinic Jacksonville in the August issue of ...

Chris Weihl Interviews Richard Mayeux

INTERVIEWS 2000-07-26 Interviews ARF: Dr. Mayeux, your research has revealed several risk factors that are associated with AD. What do you think are the most important risk factors for the development of AD? RM: I think the most significant risk factors are genetic. The ...

World Alzheimer Conference 2000: Evolving Brain Abnormalities in AD

CONFERENCE COVERAGE 2000-07-26 Conference Coverage Reported by Paul Coleman Bradley T. Hyman and Paul D. Coleman, Chairs This symposium (held 10 July) covered the gamut of age-related evolution of brain function in AD from behavioral studies emphasizing mild cognitive impairment (MCI) ...

World Alzheimer Conference 2000: Nearing Home BACE?

CONFERENCE COVERAGE 2000-07-17 Conference Coverage There were a number of oral and poster presentations relating to BACE biology (abstracts 313, 504, 540, 1013, 1269 and 1272). As with the original descriptions of BACE, the reports presented at this meeting were in broad agreement. ...

World Alzheimer Conference 2000: Presenilin's γ-Secretase Activity

CONFERENCE COVERAGE 2000-07-17 Conference Coverage Almost 12% (152) of the 1,307 abstracts presented at the 7th International Conference on Alzheimer’s Disease and related disorders made reference to presenilin (PS). For an overview of PS biology check out the webcast of Bruce Yankner ...

World Alzheimer Conference 2000: Pin1 Binds Both Tau and APP

CONFERENCE COVERAGE 2000-07-17 Conference Coverage One of the great unsolved mysteries of Alzheimer's disease is the link between the disease's two major lesions: Aβ amyloid plaques and tau tangles. Proponents of the amyloid cascade hypothesis presume that the former causes ...

World Alzheimer Conference 2000: Hot Topics in AD

CONFERENCE COVERAGE 2000-07-14 Conference Coverage Several late-breaking, dramatic results were presented at this final symposium of the meeting. Michael Hutton and colleagues from Mayo Laboratory, Jacksonville, which only a few days earlier had first publicly presented data showing ...

World Alzheimer Conference 2000: Hot Topics Symposium

CONFERENCE COVERAGE 2000-07-14 Conference Coverage Several late-breaking, dramatic results were presented at this final symposium of the meeting. Michael Hutton and colleagues from Mayo Laboratory, Jacksonville, which only a few days earlier had first publicly presented data showing ...

World Alzheimer Conference 2000: Maybe Plaques Kill Neurons after All

CONFERENCE COVERAGE 2000-07-13 Conference Coverage Although there are many reports of neurotoxic effects of amyloid when applied to neurons in culture, the evidence for toxicity in vivo has been less compelling. Of particular surprise has been the finding that most transgenic mice in ...

World Alzheimer Conference 2000: Drosophilae in the Emulsifier

CONFERENCE COVERAGE 2000-07-13 Conference Coverage The centrality of the amyloid hypothesis for AD pathology is evident at this conference not only by the sheer number of papers and posters devoted to it (708 out of a total of 1279, as opposed to 163 for apoE and 152 for presenilin, ...

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