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More Details to the β-catenin Picture

RESEARCH NEWS 1999-04-01 Research News β-catenin, a protein that regulates transcription, has drawn attention in Alzheimer's research because it interacts with PS1 and PS2. It was also recently found that AD patients with the PS1 mutation have markedly reduced β-catenin in ...

Abnormal Motion Processing in AD

RESEARCH NEWS 1999-03-22 Research News It has long been assumed that the reason Alzheimer patients tend to get lost is because of memory failure and confusion. But a new study appearing in tomorow’s issue of Neurology suggests that impaired processing of visual information may ...

Prion Soup

RESEARCH NEWS 1999-03-19 Research News Researchers in the U.K. have created conditions inside a test tube in which human prion protein can flip back and forth between normal forms and abnormal forms associated with neurodegenerative disease. In its normal form, prion protein is ...

Human ApoE Slows Plaque Deposition in Tg Mice

RESEARCH NEWS 1999-03-18 Research News Ever since the ApoE4 allele was identified as a risk factor in late-onset Alzheimer's, researchers have speculated that ApoE interacts with β-amyloid. Several years ago, Kelly Bales and colleagues at Lilly Research Laboratories ...

June Kinoshita Interviews John Hardy

INTERVIEWS 1999-03-15 Interviews ARF: What is the primary hypothesis that guides your laboratory? JH: Overall the theme of the lab is to use genetics to find what causes disease and to model the disease in cells and animals. With respect to AD, we believe that that approach ...

Major Early Intervention Study Launched

RESEARCH NEWS 1999-03-15 Research News The University of California, San Diego, Alzheimer's Disease Cooperative Study Center is launching a $22 million study to determine whether medical intervention in individuals with mild cognitive impairment (MCI), characterized ...

Chlamydia-Heart Disease Link Found

RESEARCH NEWS 1999-02-26 Research News In the mid-1980s, Finnish researchers reported that 68 percent of heart attack patients and 50 percent of those with coronary heart disease had antibodies to the bacterium Chlamydia pneumoniae, as compared to 17 percent of healthy controls. ...

Computer Simulation Captures Protein Misfolding

RESEARCH NEWS 1999-02-25 Research News Scientists at Sandia National Laboratories and M.I.T. have created the first computer simulation that successfully models how protein misfolding can occur. Protein misfolding is theorized to turn normally benign proteins into toxic ...

Insight Into Neuronal Asymmetry

RESEARCH NEWS 1999-02-24 Research News Neurons are highly polarized cells, with certain proteins within them clearly restricted to specific regions of the plasma membrane. Yet they lack any obvious barriers to free protein diffusion that could explain this asymmetric distribution ...

LTP Deficits Seen in Hsiao Mice

RESEARCH NEWS 1999-02-22 Research News Several years ago, Karen Hsiao and colleagues at the University of Minnesota reported that mice containing an FAD mutant form of the human amyloid precursor protein (APP) are impaired in their ability to learn. These mice, however, do not ...

ApoE4 Affects Recovery from Head Injury

RESEARCH NEWS 1999-01-29 Research News The E4 gene variant of apolipoprotein E (ApoE) confers an increased risk of developing Alzheimer’s disease, but the mechanisms by which it does so are not understood. ApoE plays a role in transporting fatty molecules to cell membranes, and ...

Keith A. Crutcher Interviews Rachael Neve

INTERVIEWS 1999-01-26 Interviews ARF: What’s the primary hypothesis that guides your lab group? RN: We’ve said for many years that we think that the carboxy terminal fragment of APP, that we call C100, which would result from cleavage at the N-terminus of the A-beta sequence, ...

Brian J. Cummings Interviews Paul Coleman

INTERVIEWS 1999-01-18 Interviews ARF: What is the primary hypothesis that guides your laboratory? PC: The primary hypothesis that guides my laboratory shifts from time to time as we and other people get more data; but the primary hypothesis in the lab now is that a cell in AD ...

Aileen Anderson Interviews Dennis Selkoe

INTERVIEWS 1999-01-08 Interviews ARF: What is the primary hypothesis that drives your lab group? DS: The primary hypothesis is that a chronic imbalance in the production versus the clearance of Aβ leading to a gradual rise in its steady state levels in brain tissue is the ...

Brian J. Cummings Interviews Hungtington Potter

INTERVIEWS 1998-12-22 Interviews HP: One of the few things about Alzheimer's disease on which everyone basically agrees is that it starts 20 or 30 years before the first symptoms. That means, when we look in an AD brain, we are looking at the very last stages of the ...

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