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A Sniffable Vaccine?

RESEARCH NEWS 2000-10-02 Research News A nasally administered vaccine of amyloid-β (Aβ) can significantly reduce the Aβ burden in the brains of transgenic mouse models of Alzheimer's disease, report Howard Weiner, Dennis Selkoe, and their Harvard colleagues in this month& ...

Finally, a Mitochondrial Mutant

RESEARCH NEWS 2000-10-01 Research News A feat that has eluded researchers for some time-the creation of an animal model of human mitochondrial DNA (mtDNA) diseases-has finally been accomplished. Japanese researchers report that they have created mutant mice with a large-scale ...

Another Role for the Prion: Evolutionary Key?

RESEARCH NEWS 2000-09-28 Research News The prion protein, so interesting to researchers of neurodegenerative disease for its novel capacity to cause disease through a change of conformation-and to transmit disease to other cells and organisms through its altered conformation-may ...

News Commentary on Nicastrin

RESEARCH NEWS 2000-09-15 Research News Through a nice piece of protein chemistry work, Yu and colleagues from Peter St. George Hyslop’s laboratory have shown that a novel protein, named nicastrin, associates with preseniln 1 and presenilin 2 (Yu et al., 2000). Surprisingly, this ...

Normal Prion Protein Signals with Fyn

RESEARCH NEWS 2000-09-14 Research News The intracellular protein Fyn-a suspect in the formation of neurofibrillary tangles because of its associations with tau protein-has now popped up in conjunction with prion diseases. Researchers in France report in tomorrow's Science ...

Microarrays Probe Protein Interactions

RESEARCH NEWS 2000-09-08 Research News From today's Science: Researchers have built a microarray designed to study the interactions of thousands of proteins simultaneously, helping to uncover their function. As more and more genomes are sequenced, these protein microarrays ...

Neurons Coaxed from Oligodendrocyte Precursors

RESEARCH NEWS 2000-09-08 Research News From today's issue of Science: The possibility of using stem cells from the brain to grow neural tissues has advanced a key step now that British scientists have coaxed certain nerve cells backwards in their development process to the ...

Going Beyond the DNA

RESEARCH NEWS 2000-09-06 Research News High-throughput screening for proteins is now possible, according to report in this month's Nature Biotechnology. Researchers in England have designed an array, similar to DNA microarrays, that can screen for more than 18,000 proteins ...

ApoE(ε)4 Brains Have to Work Harder

RESEARCH NEWS 2000-08-28 Research News The ε4 variant of the apolipoprotein-E (ApoE) gene has been shown to confer increased risk for Alzheimer's disease. Gary Small, Susan Bookheimer, and colleagues report in the New England Journal of Medicine that carriers of the ε4 ...

CAG Repeats Can Interfere with Transcription

RESEARCH NEWS 2000-08-28 Research News A number of inherited neurodegenerative disorders (e.g., Huntingtons's disease and spinal and bulbar muscular atrophy) have been traced to the abnormal repetition of CAG sequences in the coding for particular proteins. These mutant ...

Glutamate Transporter Identified

RESEARCH NEWS 2000-08-11 Research News A protein previously identified as a transporter of inorganic phosphate also transports glutamate into synaptic vesicles, according to a paper in today's Science by the University of California, San Francisco researcher Robert Edwards ...

Ibuprofen Reduces Plaques and Inflammation in "Hsiao" Mice

RESEARCH NEWS 2000-08-03 Research News Epidemiological studies have hinted strongly that nonsteroidal anti-inflammatory drugs (NSAIDs) might delay the progression of Alzheimer's disease. In the August 1 issue of the Journal of Neuroscience, evidence for this therapeutic ...

World Alzheimer Conference 2000: Presenilin Roundup

CONFERENCE COVERAGE 2000-08-02 Conference Coverage Reported by Mervyn Monteiro 2000 August 2. Presenilins and Lewy body pathology. Lippa et al (173) used α-synuclein immunoreactivity to determine the frequency of Lewy body (LB) occurrence in familial Alzheimer's disease (FAD) ...

World Alzheimer Conference 2000: Synuclein Update

CONFERENCE COVERAGE 2000-07-28 Conference Coverage Reported by Benjamin Wolozin, Loyola University Medical Center www.meddean.luc.edu/lumen/DeptWebs/pharm/wolozin.htm Increasing attention has focused on the role of synucleins in neurodegeneration. α-synuclein was originally cloned by ...

Imaging Plaques in AD Patients

RESEARCH NEWS 2000-07-27 Research News Joseph F. Poduslo and colleagues at Mayo Clinic report in the August issue of Nature Biotechnology (pp. 868-872) on a technique for imaging Aβ deposits in living brain. The approach may allow an earlier diagnosis of Alzheimer's disease, ...

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