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News Commentary on Nicastrin

RESEARCH NEWS 2000-09-15 Research News Through a nice piece of protein chemistry work, Yu and colleagues from Peter St. George Hyslop’s laboratory have shown that a novel protein, named nicastrin, associates with preseniln 1 and presenilin 2 (Yu et al., 2000). Surprisingly, this ...

Normal Prion Protein Signals with Fyn

RESEARCH NEWS 2000-09-14 Research News The intracellular protein Fyn-a suspect in the formation of neurofibrillary tangles because of its associations with tau protein-has now popped up in conjunction with prion diseases. Researchers in France report in tomorrow's Science ...

Microarrays Probe Protein Interactions

RESEARCH NEWS 2000-09-08 Research News From today's Science: Researchers have built a microarray designed to study the interactions of thousands of proteins simultaneously, helping to uncover their function. As more and more genomes are sequenced, these protein microarrays ...

Neurons Coaxed from Oligodendrocyte Precursors

RESEARCH NEWS 2000-09-08 Research News From today's issue of Science: The possibility of using stem cells from the brain to grow neural tissues has advanced a key step now that British scientists have coaxed certain nerve cells backwards in their development process to the ...

Going Beyond the DNA

RESEARCH NEWS 2000-09-06 Research News High-throughput screening for proteins is now possible, according to report in this month's Nature Biotechnology. Researchers in England have designed an array, similar to DNA microarrays, that can screen for more than 18,000 proteins ...

ApoE(ε)4 Brains Have to Work Harder

RESEARCH NEWS 2000-08-28 Research News The ε4 variant of the apolipoprotein-E (ApoE) gene has been shown to confer increased risk for Alzheimer's disease. Gary Small, Susan Bookheimer, and colleagues report in the New England Journal of Medicine that carriers of the ε4 ...

CAG Repeats Can Interfere with Transcription

RESEARCH NEWS 2000-08-28 Research News A number of inherited neurodegenerative disorders (e.g., Huntingtons's disease and spinal and bulbar muscular atrophy) have been traced to the abnormal repetition of CAG sequences in the coding for particular proteins. These mutant ...

Glutamate Transporter Identified

RESEARCH NEWS 2000-08-11 Research News A protein previously identified as a transporter of inorganic phosphate also transports glutamate into synaptic vesicles, according to a paper in today's Science by the University of California, San Francisco researcher Robert Edwards ...

Ibuprofen Reduces Plaques and Inflammation in "Hsiao" Mice

RESEARCH NEWS 2000-08-03 Research News Epidemiological studies have hinted strongly that nonsteroidal anti-inflammatory drugs (NSAIDs) might delay the progression of Alzheimer's disease. In the August 1 issue of the Journal of Neuroscience, evidence for this therapeutic ...

World Alzheimer Conference 2000: Presenilin Roundup

CONFERENCE COVERAGE 2000-08-02 Conference Coverage Reported by Mervyn Monteiro 2000 August 2. Presenilins and Lewy body pathology. Lippa et al (173) used α-synuclein immunoreactivity to determine the frequency of Lewy body (LB) occurrence in familial Alzheimer's disease (FAD) ...

World Alzheimer Conference 2000: Synuclein Update

CONFERENCE COVERAGE 2000-07-28 Conference Coverage Reported by Benjamin Wolozin, Loyola University Medical Center www.meddean.luc.edu/lumen/DeptWebs/pharm/wolozin.htm Increasing attention has focused on the role of synucleins in neurodegeneration. α-synuclein was originally cloned by ...

Imaging Plaques in AD Patients

RESEARCH NEWS 2000-07-27 Research News Joseph F. Poduslo and colleagues at Mayo Clinic report in the August issue of Nature Biotechnology (pp. 868-872) on a technique for imaging Aβ deposits in living brain. The approach may allow an earlier diagnosis of Alzheimer's disease, ...

NFTs in Mice

RESEARCH NEWS 2000-07-27 Research News Mice carrying the P301 mutation in tau, which causes human frontotemporal dementia, develop neurofibrillary pathology with features mimicking those of human tauopathies, report scientists at Mayo Clinic Jacksonville in the August issue of ...

Chris Weihl Interviews Richard Mayeux

INTERVIEWS 2000-07-26 Interviews ARF: Dr. Mayeux, your research has revealed several risk factors that are associated with AD. What do you think are the most important risk factors for the development of AD? RM: I think the most significant risk factors are genetic. The ...

World Alzheimer Conference 2000: Evolving Brain Abnormalities in AD

CONFERENCE COVERAGE 2000-07-26 Conference Coverage Reported by Paul Coleman Bradley T. Hyman and Paul D. Coleman, Chairs This symposium (held 10 July) covered the gamut of age-related evolution of brain function in AD from behavioral studies emphasizing mild cognitive impairment (MCI) ...

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