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A New Link Between Pesticides and Parkinson's Disease

RESEARCH NEWS 2000-11-05 Research News Parkinson's disease is one of the most common neurodegenerative diseases, affecting about one percent of all people over the age of 65. It is characterized by rigidity, bradykinesia (reduced movement) and tremors, which are caused by ...

Society for Neuroscience Annual Meeting: Stem Cells Drawn to Aβ

CONFERENCE COVERAGE 2000-11-05 Conference Coverage A central problem in Alzheimer's disease is to understand how Aβ affects the brain's biology, and how it contributes to neurodegeneration. A diverse array of mechanisms have been proposed, including direct toxicity, ...

APP and Its Relatives: Some Are Redundant and Some Are Not

RESEARCH NEWS 2000-11-01 Research News It is not only the abnormal product of amyloid precursor protein-the amyloid-beta peptide-that interests researchers of Alzheimer's disease. There is also a line of inquiry that hopes to find clues to the disease in the normal function ...

Further Progress Against Parkinson's

RESEARCH NEWS 2000-10-27 Research News Following on the heels of a report on a two-gene therapy approach to rescue neurons in a mouse Parkinson's model, a new study published today in Science finds that GDNF genes delivered by a lentiviral vector reversed functional deficits ...

Progress in Neural Stem Cell Research

RESEARCH NEWS 2000-10-05 Research News Neural stem cells have been heralded as a potential therapy to rebuild injured and diseased brain tissue, but to achieve that vision, researchers must decipher the molecular signals that direct the cells to migrate through the brain and ...

Gene Therapy Rescues Neurons in Parkinson's Model

CONFERENCE COVERAGE 2000-10-05 Conference Coverage A two-gene therapy strategy prevents the death of dopamine neurons and preserves their function, according to a study by Jorg Schulz and colleagues at the University of Tubingen in Germany. The study was carried out in an MPTP mouse ...

β-Secretase 3D Structure

RESEARCH NEWS 2000-10-04 Research News Researchers announced a step forward in the rational design of drugs to inhibit β-secretase (also called memapsin 2 and BACE) with the publication in tomorrow's Science of the crystal structure of the enzyme locked in a complex with a ...

A Sniffable Vaccine?

RESEARCH NEWS 2000-10-02 Research News A nasally administered vaccine of amyloid-β (Aβ) can significantly reduce the Aβ burden in the brains of transgenic mouse models of Alzheimer's disease, report Howard Weiner, Dennis Selkoe, and their Harvard colleagues in this month& ...

Finally, a Mitochondrial Mutant

RESEARCH NEWS 2000-10-01 Research News A feat that has eluded researchers for some time-the creation of an animal model of human mitochondrial DNA (mtDNA) diseases-has finally been accomplished. Japanese researchers report that they have created mutant mice with a large-scale ...

Another Role for the Prion: Evolutionary Key?

RESEARCH NEWS 2000-09-28 Research News The prion protein, so interesting to researchers of neurodegenerative disease for its novel capacity to cause disease through a change of conformation-and to transmit disease to other cells and organisms through its altered conformation-may ...

News Commentary on Nicastrin

RESEARCH NEWS 2000-09-15 Research News Through a nice piece of protein chemistry work, Yu and colleagues from Peter St. George Hyslop’s laboratory have shown that a novel protein, named nicastrin, associates with preseniln 1 and presenilin 2 (Yu et al., 2000). Surprisingly, this ...

Normal Prion Protein Signals with Fyn

RESEARCH NEWS 2000-09-14 Research News The intracellular protein Fyn-a suspect in the formation of neurofibrillary tangles because of its associations with tau protein-has now popped up in conjunction with prion diseases. Researchers in France report in tomorrow's Science ...

Microarrays Probe Protein Interactions

RESEARCH NEWS 2000-09-08 Research News From today's Science: Researchers have built a microarray designed to study the interactions of thousands of proteins simultaneously, helping to uncover their function. As more and more genomes are sequenced, these protein microarrays ...

Neurons Coaxed from Oligodendrocyte Precursors

RESEARCH NEWS 2000-09-08 Research News From today's issue of Science: The possibility of using stem cells from the brain to grow neural tissues has advanced a key step now that British scientists have coaxed certain nerve cells backwards in their development process to the ...

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