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How to Misfold a Prion Protein

RESEARCH NEWS 1999-09-13 Research News In the current Nature Cell Biology, Susan Lindquis and Jiang Ma of the Howard Hughes Institute at the University of Chicago report that they were able to produce abnormal prion protein (PrP) conformations from normal PrP, apparently by ...

Aβ and Tau Accumulation in an Animal Model of Brain Trauma

RESEARCH NEWS 1999-08-31 Research News Douglas Smith and his colleagues at the University of Pennsylvania may have filled a gap in research on long-term, neurodegeneration sequelae of brain injuries by showing Aβ and tau production in an animal model of brain trauma. Their ...

TNF-α Reveals Another Deadly Trick

RESEARCH NEWS 1999-08-26 Research News If the inflammatory cytokine tumor necrosis factor α (TNF-α) is at work in Alzheimer's disease, it may not be relying on its well-described, directly apoptotic mechanism to cause problems, according to a report by Keith W. Kelley and ...

AD Mouse Model with Whole APP and PS-1 Genes

RESEARCH NEWS 1999-07-29 Research News In the August issue of Nature Neuroscience, Bruce Lamb and his associates at Case Western report that they have transferred complete copies of genes for mutant human APP and PS-1 into mice that subsequently produce high levels of Aβ and ...

DNA Damage Surveillance after Head Injury

RESEARCH NEWS 1999-07-28 Research News Various recent studies have reported a link between head trauma and and an increased risk of Alzheimer's disease, but why this might be has been a matter of speculation. In this month’s Journal of Neurochemistry, Tracy McIntosh, ...

Vaccinating Against Plaques

RESEARCH NEWS 1999-07-07 Research News Findings reported in tomorrow’s issue of Nature raise the tantalizing possibility of using vaccination to prevent or ameliorate Alzheimer’s disease. In the study, by Dale Schenk and colleagues at Elan Pharmaceuticals, PDAPP transgenic mice ...

For Lack of a Stop Codon

RESEARCH NEWS 1999-06-23 Research News In tomorrow's issue of Nature, Jorge Ghiso and colleagues at New York University, and coworkers at the National Hospital for Neurology and Neurosurgery in London, report that they have found the gene mutation that produces the amyloid ...

PIN1 Restores Phosphorylated Tau Function

RESEARCH NEWS 1999-06-23 Research News In tomorrow’s issue of Nature (pp. 784-788), Kun Ping Lu of Harvard Medical School and colleagues report that an enzyme, prolyl isomerase Pin1, binds to phosphorylated tau from Alzheimer’s patients and restores tau’s ability to bind to ...

Novel APP-p53 Interaction Found

RESEARCH NEWS 1999-06-22 Research News Neurons taken from the brains of deceased Alzheimer's patients exhibit markers for apoptosis, but little is known about what induces the expression of apoptotic genes. In today’s proceedings of the National Academy of Science, a ...

The AMPA Receptor Steps out of the Shadows

RESEARCH NEWS 1999-06-21 Research News Researchers studying the molecular basis of long-term potentiation (LTP) have typically focused on the role of NMDA glutamate receptor, but two papers published in the June 11 issue of Science elucidate the role of the other glutamate ...

Peter Nelson Interviews Karen Duff

INTERVIEWS 1999-06-15 Interviews ARF: Your work, although concentrating upon pathological states, seems applicable to both normal and disease-related biology. Is there a particular hypothesis which drives your work? KD: When you look at an AD brain at post-mortem, the most ...

ApoE4 Testing Rejected by Ethics Panel

COMMUNITY NEWS 1999-06-10 Community News Genetic testing for the ApoE allele should not be used to aid diagnosis of the sporadic form of Alzheimer's disease, concludes a Stanford University biomedical ethics committee. The E4 variant of the ApoE gene elevates a person's ...

Aging and Pathology Interacting in the Cholinergic System

RESEARCH NEWS 1999-06-08 Research News The "cholinergic hypothesis" of cognition places emphasis on the role of cholinergic neurons in the basal forebrain and their projections to cortical areas. This hypothesis is based to a large extent on findings that this system is ...

A Note of Caution about COX-2 Inhibitors

RESEARCH NEWS 1999-06-01 Research News Hopes have been raised that drugs which inhibit the proinflammatory COX-2 enzyme could be effective in treating rheumatoid arthritis and perhaps also Alzheimer's disease, which many scientists think is exacerbated by inflammatory ...

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