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Vast Yet Tiny? Charting the New World of microRNAs

RESEARCH NEWS 2001-10-25 Research News Entire new classes of molecules don't come along every day, so it is worth noting that the classic triumvirate of RNA-mRNA, tRNA, rRNA-has just gotten a baby brother. Three independent research teams are reporting in tomorrow's ...

Drugs Slow Neurodegeneration in Fly Model of Huntington's

RESEARCH NEWS 2001-10-19 Research News One hypothesis for how polyglutamine (poly-Q) repeats in the huntingtin protein might cause disease holds that they somehow perturb gene expression. This notion is getting more traction from a paper in yesterday's Nature, which shows ...

Consolidating and Retrieving Memories: News on Two Fronts

RESEARCH NEWS 2001-10-18 Research News The Where? Key Role Found for Entorhinal Cortex, Area of Earliest Neuron Death in Alzheimer's It has become almost a truism in memory research that the seahorse-shaped brain area called the hippocampus is key to memory formation. It ...

COX-2 Overexpression Tied to Memory Loss and Apoptosis

RESEARCH NEWS 2001-10-15 Research News Chronically elevated levels of cyclooxygenase-2 (COX-2), which catalyzes the first step in the synthesis of prostaglandins from arachidonic acid, have been correlated with induction of neuronal apoptosis, suggesting this enzyme may play a ...

Mitochondrial Gene Knockouts Lead to Late-Onset Neurodegeneration

RESEARCH NEWS 2001-10-15 Research News Mitochondria, through their pivotal roles in apoptosis and generation of reactive oxygen species (ROS), are increasingly being implicated in the pathogenesis of neurodegenerative diseases. Researchers in the lab of Nils-Göran Larsson at the ...

New Candidate Gene for Parkinson's Disease

RESEARCH NEWS 2001-10-15 Research News Last year researchers identified a mutation in rats, the so-called agu mutation (Payne et al), which resulted in a phenotype resembling human Parkinsonism. In November's Nature Neuroscience, available online today, scientists at Wayne ...

Aβ Abets α-Synuclein

RESEARCH NEWS 2001-10-08 Research News A new double-transgenic mouse may provide a good model for Lewy-body diseases and offer insight into mechanisms that underlie Alzheimer's and Parkinson's disease. Eliezer Masliah and colleagues at University of California, San ...

Identification of New Gene Boosts ALS Research

RESEARCH NEWS 2001-10-03 Research News Most cases of amyotrophic lateral sclerosis (ALS) have no familial history that could help researchers home in on genetic causes. About 10 percent of cases are inherited, from which five potential ALS genes have been mapped to independent ...

Parkin and α-synuclein Linked Through Synphilin-1

RESEARCH NEWS 2001-10-01 Research News One of the hallmarks of sporadic Parkinson's disease (PD) are Lewy bodies (LB), neuronal cytoplasmic inclusions that contain ubiquitinated proteins. Recently researchers have focused on two key LB components, the 16 kDa α-synuclein, and ...

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