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Society for Neuroscience Annual Meeting: Immunization of Mice and Men

CONFERENCE COVERAGE 2000-11-15 Conference Coverage What is the latest on the immunization of mice and men with Aβ? Will we be celebrating victory over Alzheimer’s disease in a few years (and looking for new jobs), or has the story been overrated? One would predict to see a number of ...

Society for Neurosci Ann Mtg: Passive Aβ Immunization Works in Mice

CONFERENCE COVERAGE 2000-11-15 Conference Coverage A current working hypothesis in the field of AD research is that preventing the accumulation of Aß peptides will slow or prevent cognitive decline. Two main strategies for accomplishing this goal have been pursued in recent years. The ...

Society for Neuroscience Annual Meeting: LRP: Guilt by Association

CONFERENCE COVERAGE 2000-11-14 Conference Coverage One of the most daunting tasks facing attendees of this gigantic neuroscience data exchange (dare I say "flea market"?) is identifying signals in the noise (speaking both scientifically and literally). One approach is to sit ...

Molecular Clue to Alzheimer's Mystery Found

RESEARCH NEWS 2000-11-13 Research News In today's Journal of Cell Biology, researchers of the University of Maryland Biotechnology Institute (UMBI) report that a molecule called ubiquilin regulates levels of presenilins, and is "highly expressed" in human neurons ...

Society for Neuroscience Annual Meeting: The Ghost of D’Arcy Thompson

CONFERENCE COVERAGE 2000-11-10 Conference Coverage What do ßamyloid, buckyballs, and dark matter have in common? They were all mentioned in an intriguing presentation by Dr. Westlind-Danielsson (AstraZeneca, Abstract 299.2) on the formation of spheroidal "supramolecular structures ...

Soc for Neurosci Annual Meeting: Explaining Finicky Toxicity of Aβ

CONFERENCE COVERAGE 2000-11-09 Conference Coverage It's a poorly kept secret that Aβ peptides are highly inconsistent in their neurotoxic properties. One batch of synthetic peptide will kill neurons handily, while another will be benign. Sarah Wright and her colleagues at Elan ...

Society for Neuroscience Annual Meeting: A Glimpse into the Future?

CONFERENCE COVERAGE 2000-11-09 Conference Coverage The award for most aesthetically pleasing presentation almost certainly could go to Dr. Paul Thompson, who reviewed recent advances being made by a UCLA team in developing AD-specific brain atlases for assessing alterations in the ...

Society for Neuroscience Annual Meeting: Triumph of the NERD

CONFERENCE COVERAGE 2000-11-09 Conference Coverage At least I hope they will come. Brian Cummings presented an overview of a web-based database for Alzheimer’s cases (known as the Neuropathological Examination Research Database or NERD) that could serve as a model for other AD centers ...

Linking Free Radicals to Neurodegenerative Disease

RESEARCH NEWS 2000-11-07 Research News A number of lines of evidence implicate oxidative damage caused by free radicals-particularly reactive oxygen species-as having some role, perhaps even a major or causative one, in the etiology of neurodegenerative diseases. Writing in ...

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