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Sixth Int. Conference on AD: Scientists Smitten by Mad Tau Disease

CONFERENCE COVERAGE 1998-07-22 Conference Coverage A new epidemic of "mad tau disease" swept Amsterdam at the workshop on Hereditary Fronto-Temporal Dementia and Pick's disease. Fronto-temporal dementia and Parkinsonism linked to chromosome 17 (FTDP-17) has been linked ...

Sixth Int. Conference on AD: Fibril-busting Mystery Herb

CONFERENCE COVERAGE 1998-07-22 Conference Coverage While a number of drug companies have been pumping big bucks into creating novel molecules capable of inhibiting formation of Aβ fibrils, along comes Alan Snow and his colleagues at the University of Washington and his Seattle-based ...

Sixth Int. Conference on AD: Presenilin-binding Proteins Abound

CONFERENCE COVERAGE 1998-07-22 Conference Coverage Because presenilin was discovered in positional cloning experiments involving large familial Alzheimer's disease kindreds, there were no previous data concerning its biological function. As a result, many groups have used a ...

Sixth Int. Conference on AD: Aging Astrocytes: A Role in AD?

CONFERENCE COVERAGE 1998-07-22 Conference Coverage Yamaguchi (Abstract 1245) presented his theory that very diffuse plaques within nondemented individuals are cleared by astrocytic phagocytosis. He showed many examples of very diffuse Aβ-positive staining within the brains of 40-50 ...

Sixth Int. Conference on AD: Development of Aβ Peptide Inhibitors

CONFERENCE COVERAGE 1998-07-21 Conference Coverage If you came to Amsterdam hoping to hear a lot of new data on Aβ peptide inhibitors, you might have learned more by window shopping in the red-light district. This doesn't mean that the session was without merit. Barbara Cordell ...

Sixth Int. Conference on AD: Roundtable C: Metabolism and Alzheimer's

CONFERENCE COVERAGE 1998-07-21 Conference Coverage Over a decade ago, John Blass and his colleagues proposed that AD was caused by compromised metabolism. Today, this theory has gained support from a convergence of numerous therapeutic, pathological and biochemical studies pointing to ...

Sixth Int. Conference on AD: Satellite Symposium on AD7c-NTP

CONFERENCE COVERAGE 1998-07-21 Conference Coverage 21 July 1998. The focus of this symposium was the biology and diagnostic value of a recently discovered protein, termed AD7c-neuronal thread protein (NTP), in Alzheimer's disease (AD). Dr. Suzanne de la Monte presented the ...

Sixth Int. Conference on AD: Pathology I

CONFERENCE COVERAGE 1998-07-20 Conference Coverage Three abstracts presented during this session, as well as those by Vincent et al. (Abstract 594) and Arendt et al. (Abstract 595), indicate that cell cycle and mitotic mechanisms may be a key factor in the understanding of tau ...

Sixth Int. Conference on AD: Mahley Plenary Lecture

CONFERENCE COVERAGE 1998-07-19 Conference Coverage B. Mahley (Abstract 303) reported new data on transgenic mice that could help elucidate the role of ApoE isoforms in neurodegeneration. He began his lecture with an overview of the structure and function of apolipoprotein E (ApoE), a ...

Sixth Int. Conference on AD: Cellular/Animal Models I

CONFERENCE COVERAGE 1998-07-18 Conference Coverage Soto (Abstract 295) presented data documenting the ability of their 11 and 5 amino-acid inhibitors to inhibit initial Aβ peptide aggregation and its ability to dissociate already formed Aβ fibrils in vitro. In addition to the assays ...

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