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RESEARCH NEWS 2005-01-13 Research News In efforts to interfere with Aβ peptide production, most of the attention has been lavished on the β- and γ-secretase enzymes. Could, however, their neglected cousin α-secretase prove to be the better target? In an article published January
RESEARCH NEWS 2005-01-07 Research News You can have too much of a good thing. Glutamate, for example, is one of the major excitatory neurotransmitters, but too much of it is toxic to neurons. In yesterday’s Nature, Paul Fisher and colleagues reveal that common β-lactam antibiotic
RESEARCH NEWS 2005-01-07 Research News Taxols, drugs that are commonly used to treat cancer, may offer some therapeutic benefit for patients suffering from Alzheimer disease (AD) and other neurodegenerative diseases, such as frontotemporal dementia, in which aggregates of the mic
RESEARCH NEWS 2005-01-07 Research News A report in the January issue of the Archives of General Psychiatry reinforces earlier observations that some antipsychotic drugs may increase the risk for, or even cause, diabetes in patients with schizophrenia. Since these drugs are often
RESEARCH NEWS 2004-12-23 Research News Mutations in parkin can cause familial Parkinson disease (see ARF related news story), but how normal parkin may contribute, if at all, to non-familial PD is more of a mystery. In last week’s Neuron, Andres Lozano and colleagues at the Unive
RESEARCH NEWS 2004-12-22 Research News A paper published online 19 December in Nature Neuroscience takes aim at two omnipresent issues in Alzheimer disease research: Which form(s) of β amyloid (Aβ) are toxic and do symptoms such as subtle cognitive deficits require antecedent neu
RESEARCH NEWS 2004-12-22 Research News With safety concerns about rofecoxib (Vioxx®), celecoxib (Celebrex®), and now naproxen, it seems that nonsteroidal antiinflammatories (NSAIDs) are dropping like flies. On Monday last, the National Institute on Aging halted the Alzheimer’s Di
RESEARCH NEWS 2004-12-20 Research News The curry spice curcumin is a potent antioxidant and has been investigated by Greg Cole's team at the University of California, Los Angeles, for possible protective roles in Alzheimer disease inflammatory processes (see ARF related news
CONFERENCE COVERAGE 2004-12-20 Conference Coverage Speakers include: Randolph Hampton Paul Muchowski Ana Maria Cuervo Ralph Nixon Cynthia McMurray Randolph Hampton of University of California, San Diego, introduced the audience to his lab’s work on quality control pathways, which serve
RESEARCH NEWS 2004-12-18 Research News In an article published online 29 November 2004 in the Journal of Biological Chemistry, Dennis Selkoe's team reports further evidence placing the mature γ-secretase complex at the cell surface, and implicating it in cleavage of amyloid-
CONFERENCE COVERAGE 2004-12-17 Conference Coverage Speakers include: Harald Janovjak Eckhard Mandelkow Judith Frydman James Bowie Charlie Glabe See the movie What new techniques have come on line to study protein misfolding? Harald Janovjak introduced the audience to the latest refinem
CONFERENCE COVERAGE 2004-12-16 Conference Coverage To the student of neurodegenerative diseases, the Society for Neuroscience conference can seem like an overloaded buffet where only morsels of the food tickle one’s taste buds. By comparison, the satellite meetings offer a carefully se
RESEARCH NEWS 2004-12-16 Research News Society’s solution to energy requirements is to generate power remotely, then transmit it over vast distances. In contrast, biological systems adopt a local approach, generating power wherever it is needed. Perhaps nowhere is this more evide
RESEARCH NEWS 2004-12-16 Research News If you have an accident, calling 911, or your local equivalent, will get you the paramedics. In case of neural injury, dialing up SDF-1 might get you a dose of much-needed stem cells, while class 1 MHC molecules might be just what you need t
RESEARCH NEWS 2004-12-15 Research News Though there is already plenty of evidence linking lipid metabolism and obesity to Alzheimer disease (AD) and other neurodegenerative diseases (see, for example, ARF related news story and ARF news story), the case just got stronger. Reporti
