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Society for Neuroscience Annual Meeting: α-Synuclein: A Review

CONFERENCE COVERAGE 1999-11-03 Conference Coverage Hashimoto, Masliah and colleagues (27.14) reported that cytochrome C stimulates α-synuclein aggregration in vitro and that cytochrome C can be observed in Lewy bodies, in postmortem brain tissue. Whether cytochrome C actually plays a ...

Society for Neuroscience Annual Meeting: Presenilins: An Overview

CONFERENCE COVERAGE 1999-11-01 Conference Coverage Research on presenilins presented at this year's meeting centered around two major questions: 1) What is the role of presenilins in Aβ production and APP processing, and 2) what are the other biological actions of presenilins? A ...

Society for Neuroscience Annual Meeting: Be Wise—Immunize!

CONFERENCE COVERAGE 1999-10-26 Conference Coverage In the relatively short time allotted, Dale Schenk (519.5) managed to describe most of the data from his group’s recent Nature paper (Nature 1999;400:173-177), and a little more. Schenk demonstrated that Aβ immunization of young (six ...

Society for Neuroscience Annual Meeting: A Sniff of Aβ

CONFERENCE COVERAGE 1999-10-26 Conference Coverage Chronic mucosal administration of certain proteins is known to decrease organ-specific autoimmune processes in several autoimmune models, including those affecting the CNS. In AD, local inflammatory responses frequently occur in the ...

Soc for Neuroscience Annual Meeting: Lipoproteins Reduce Clearance of Aβ

CONFERENCE COVERAGE 1999-10-25 Conference Coverage Using exquisite human primary cortical cultures containing neurons, astrocytes, and microglia, Nadeau (319.1) demonstrated that addition of VLDLs or HDLs increased media levels of both Aβ40 and Aβ42. Moreover, addition of ApoE3, Apo4 ...

Soc for Neuroscience Ann Mtg: Reduced Cholesterol Levels Inhibit Aβ

CONFERENCE COVERAGE 1999-10-25 Conference Coverage Using primary hippocampal neurons transfected with APP by means of the Semliki-forest-virus expression system Christine Bergmann (319.2) demonstrated that lovastatin (which inhibits de novo cholesterol synthesis) and methyl-b ...

Society for Neuroscience Annual Meeting: Intraneuronal Aβ

CONFERENCE COVERAGE 1999-10-25 Conference Coverage Until very recently, Aβ accumulation and aggregation were thought to be exclusively extracellular phenomena. However, a number of abstracts presented at this meeting (see 120.10 and 720.10) suggest that this notion must be revisited. ...

Society for Neuroscience Annual Meeting: DIGs—a Site of Aβ?

CONFERENCE COVERAGE 1999-10-25 Conference Coverage Kawarabayashi (319.10) presented compelling data for a time-dependent accumulation of Aβ in the detergent-insoluble glycolipid enriched membrane domains (DIGs) of Tg2576 mouse brain. He also showed that Aβ accumulated in DIGs from ...

Society for Neuroscience Annual Meeting: The TGN—Where It's Happening?

CONFERENCE COVERAGE 1999-10-25 Conference Coverage In an exhaustive study, Iwata (240.1) presented evidence that the trans Golgi network was the major site of Aβ42 production in both neural and non-neural cells. Cos-1 and N2a cells were transfected with C100 bearing retention signals ...

Society for Neuroscience Annual Meeting: TACE, TAPI, and ADAM10

CONFERENCE COVERAGE 1999-10-25 Conference Coverage The mechanisms of regulated α-secretase cleavage were thoroughly examined in two excellent companion posters from Virginia Lee’s lab (240.2, 240.3). The authors demonstrated that TNFalpha converting enzyme (TACE) knockout mice show ...

Society for Neuroscience Annual Meeting: Endocrepsin is BACE

CONFERENCE COVERAGE 1999-10-25 Conference Coverage At times the scene around this poster (240.11) was more like a football scrimmage or a rugby scrum than the normally genteel atmosphere associated with a scientific event. By the time I made my way to within sight of the poster, the ...

Soc for Neuroscience Ann Mtg: Proteasome Inhibition Boosts Aβ

CONFERENCE COVERAGE 1999-10-25 Conference Coverage Janet Johnston (240.16) presented a detailed study of the effect of proteasome and prolendopeptidase (PEP) inhibitors on Aβ production by SH SY 5Y human neuroblastoma cells stably transfected with SPA4CT (C99). Both the proteasome and ...

Society for Neuroscience Annual Meeting: APP Binds to Fibrillar Aβ

CONFERENCE COVERAGE 1999-10-24 Conference Coverage Treatment of human cerebovascular smooth muscle (HCSM) cells with Aβ1-42 or AβQ22 (a mutant associated with hereditary cerebral hemorrhage with amyloidosis-Dutch type) leads to the formation of amyloid fibrils on the surface of HCSM ...

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