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Shining Light on Proteins Touching

RESEARCH NEWS 2001-10-31 Research News A better understanding of precisely how AβPP is processed to generate the Aβ peptide and other, poorly understood proteolytic products has become a priority in Alzheimer's research. In the November 1 Journal of Neuroscience, Ayae ...

Why Do Only Some Neurons Die in Parkinson's?

RESEARCH NEWS 2001-10-31 Research News In Parkinson's disease, as in Alzheimer's, it remains unclear why only a subset of neurons is affected. A report in tomorrow's Journal of Neuroscience now suggests that, in PD, the reason for that specificity may lie in immune ...

α-Synuclein Aggregation Prevented by β-Homolog

RESEARCH NEWS 2001-10-30 Research News α-synuclein is one of the major proteins found in Lewy bodies (LBs), the cytoplasmic inclusions that pepper the neurons of patients suffering from one of several neurodegenerative diseases, including Parkinson's, Alzheimer's, and ...

New Gene for Hereditary Spastic Paraplegia Found

RESEARCH NEWS 2001-10-30 Research News An international team lead by John Fink, University of Michigan, has identified a new gene responsible for hereditary spastic paraplegia (HSP). This disorder, which starts in early childhood and can completely paralyze both legs, has been ...

A New Candidate Neuroprotective Mechanism for Estrogen

RESEARCH NEWS 2001-10-29 Research News 29 October 2001. Estrogen replacement therapy may protect postmenopausal women from Alzheimer's disease, according to some epidemiological studies. For example, a recent short trial of high-dose 17β-estradiol found significant ...

Susceptibility Gene Mapped for Late-Onset Parkinson's Disease?

RESEARCH NEWS 2001-10-26 Research News Scientists at the Icelandic genomics company DeCode Genetics, working with colleagues at the National University Hospital in Reykjavik, have presented at last week's meeting of the American Society for Human Genetics in San Diego a ...

γ-Secretase Found to Cleave Receptor Tyrosine Kinase ErbB-4

RESEARCH NEWS 2001-10-25 Research News The ErbB family of cell surface receptors is involved in the transduction of cellular growth and proliferation signals; ErbB-1 and ErbB-2, for example, have been implicated in aggressive forms of breast cancer. In tomorrow's Science ...

Vast Yet Tiny? Charting the New World of microRNAs

RESEARCH NEWS 2001-10-25 Research News Entire new classes of molecules don't come along every day, so it is worth noting that the classic triumvirate of RNA-mRNA, tRNA, rRNA-has just gotten a baby brother. Three independent research teams are reporting in tomorrow's ...

Drugs Slow Neurodegeneration in Fly Model of Huntington's

RESEARCH NEWS 2001-10-19 Research News One hypothesis for how polyglutamine (poly-Q) repeats in the huntingtin protein might cause disease holds that they somehow perturb gene expression. This notion is getting more traction from a paper in yesterday's Nature, which shows ...

Consolidating and Retrieving Memories: News on Two Fronts

RESEARCH NEWS 2001-10-18 Research News The Where? Key Role Found for Entorhinal Cortex, Area of Earliest Neuron Death in Alzheimer's It has become almost a truism in memory research that the seahorse-shaped brain area called the hippocampus is key to memory formation. It ...

COX-2 Overexpression Tied to Memory Loss and Apoptosis

RESEARCH NEWS 2001-10-15 Research News Chronically elevated levels of cyclooxygenase-2 (COX-2), which catalyzes the first step in the synthesis of prostaglandins from arachidonic acid, have been correlated with induction of neuronal apoptosis, suggesting this enzyme may play a ...

Mitochondrial Gene Knockouts Lead to Late-Onset Neurodegeneration

RESEARCH NEWS 2001-10-15 Research News Mitochondria, through their pivotal roles in apoptosis and generation of reactive oxygen species (ROS), are increasingly being implicated in the pathogenesis of neurodegenerative diseases. Researchers in the lab of Nils-Göran Larsson at the ...

New Candidate Gene for Parkinson's Disease

RESEARCH NEWS 2001-10-15 Research News Last year researchers identified a mutation in rats, the so-called agu mutation (Payne et al), which resulted in a phenotype resembling human Parkinsonism. In November's Nature Neuroscience, available online today, scientists at Wayne ...

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