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INTERVIEWS 2005-05-20 Interviews Howard Fillit Howard Fillit is the executive director of the Institute for the Study of Aging (ISOA), a biomedical venture philanthropy funding drug discovery for Alzheimer disease. Since 1998, the ISOA has committed more than $23 million in
RESEARCH NEWS 2005-05-20 Research News Dogma holds that presenilins in the γ-secretase complex beget amyloid-β (Aβ) peptides by cleaving the membrane-bound β amyloid precursor protein (AβPP). But new results show there is (literally) another piece to the story. That piece is the
RESEARCH NEWS 2005-05-19 Research News Updated 21 January 2005: Science magazine has formally retracted this paper because its data were fabricated; see ARF related news story. In February 2004, researchers at Seoul National University in Korea surprised the world when they repor
RESEARCH NEWS 2005-05-18 Research News ApoE figures large in Alzheimer disease as the only known genetic risk factor for sporadic AD and an important regulator of amyloid-β (Aβ) metabolism and deposition (see ARF related news story). But for all the attention focused on this litt
RESEARCH NEWS 2005-05-16 Research News Immunotherapy, through either passive or active immunization, remains a viable and aggressively pursued strategy for ridding the brain of amyloid β, the major component found in the amyloid plaques that are the hallmark of Alzheimer disease
RESEARCH NEWS 2005-05-13 Research News A mixed bag of epidemiologic studies alternatively hold up and knock down the promise that widely prescribed cholesterol-lowering statin drugs might offer some protection against Alzheimer disease progression (see ARF related news story). La
RESEARCH NEWS 2005-05-06 Research News Adult stem cells in the intestine and skin of mice can be induced to multiply massively by the introduction of a master gene regulatory protein derived from embryonic stem cells. This finding, reported in the May 6 Cell by Rudy Jaenisch and
RESEARCH NEWS 2005-05-05 Research News Mutant proteins that cause neurodegenerative disease, such as amyloid-β precursor protein, parkin, and huntingtin, are produced in many different neurons of the brain. So why do only certain subtypes of neurons degenerate in Alzheimer diseas
RESEARCH NEWS 2005-05-05 Research News Mice live longer and show signs of delayed aging when they express the antioxidant enzyme catalase in their mitochondria, according to a report appearing today in Science online. The results of the study, by Peter Rabinovitch and his colleag
RESEARCH NEWS 2005-05-04 Research News Amyloid-β (Aβ) comes in many forms, including monomers, oligomers, protofibrils, and fibrils. Protofibrils have emerged as perhaps the most toxic form of the peptide (see ARF related news story and ARF news story), but because these species
RESEARCH NEWS 2005-04-30 Research News Originally, vaccination with amyloid-β (Aβ) peptides aimed to fight Alzheimer disease by enlisting the immune system to clear aggregated amyloid plaques from the brain. But there is mounting evidence that soluble forms of Aβ, and particularl
RESEARCH NEWS 2005-04-28 Research News The development of neurotrophic factors for treatment of Alzheimer disease (AD) and other neurodegenerative disorders has proceeded in fits and starts, in no small part due to the difficulty of delivering peptide factors where they are neede
RESEARCH NEWS 2005-04-27 Research News With the exception of familial cases, which can be traced to specific mutations, it is unclear why there’s a glut of amyloid-β (Aβ) in the brains of Alzheimer disease patients. The most simplistic explanations are that too much is formed or
RESEARCH NEWS 2005-04-22 Research News Though microglia, the housekeeping cells of the central nervous system, have been implicated in the clearance of amyloid-β (see ARF related news story), they have also long been thought to be passive bystanders, only springing into action wh
INTERVIEWS 2005-04-21 Interviews Bud Kukull Walter (Bud) Kukull is the principal investigator of The National Alzheimer's Coordinating Center (NACC), which facilitates collaborative research among the approximately 29 Alzheimer's Disease Centers funded by the Natio
