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Neurotoxic Homocysteine Metabolite Boosts Intracellular Aβ

RESEARCH NEWS 2005-05-26 Research News The epidemiologic link between elevated blood homocysteine (HC) and Alzheimer disease (see ARF related news story) has spurred the search for the mechanisms by which this ubiquitous amino acid might damage neurons. HC has been directly linke

You Gotta Keep 'em Separated—New Strategy for Targeting γ-secretase?

RESEARCH NEWS 2005-05-23 Research News The intramembrane protease activity of γ-secretase is a prime target for therapeutic strategies aimed at treating Alzheimer disease by blocking amyloid β (Aβ) production (see ARF related Sorrento news story). But the biggest fly in the poten

The Cost of Making Memories

RESEARCH NEWS 2005-05-21 Research News Trauma aside, we tend to think of our ability to store and retrieve memories as a good thing—but at what cost? In a brief article in today’s Science, Frederic Mery and Tadeusz Kawecki at the University of Fribourg, Switzerland, report that i

Tom Fagan Interviews Howard Fillit

INTERVIEWS 2005-05-20 Interviews   Howard Fillit Howard Fillit is the executive director of the Institute for the Study of Aging (ISOA), a biomedical venture philanthropy funding drug discovery for Alzheimer disease. Since 1998, the ISOA has committed more than $23 million in

The Theology of Aβ: Presenilins Giveth, and They Taketh Away

RESEARCH NEWS 2005-05-20 Research News Dogma holds that presenilins in the γ-secretase complex beget amyloid-β (Aβ) peptides by cleaving the membrane-bound β amyloid precursor protein (AβPP). But new results show there is (literally) another piece to the story. That piece is the

Personalized Stem Cells Make Debut

RESEARCH NEWS 2005-05-19 Research News Updated 21 January 2005: Science magazine has formally retracted this paper because its data were fabricated; see ARF related news story. In February 2004, researchers at Seoul National University in Korea surprised the world when they repor

Lack of Lipoprotein Receptor Boosts Brain ApoE, but Not Aβ

RESEARCH NEWS 2005-05-18 Research News ApoE figures large in Alzheimer disease as the only known genetic risk factor for sporadic AD and an important regulator of amyloid-β (Aβ) metabolism and deposition (see ARF related news story). But for all the attention focused on this litt

A New BACE for Immunotherapy

RESEARCH NEWS 2005-05-16 Research News Immunotherapy, through either passive or active immunization, remains a viable and aggressively pursued strategy for ridding the brain of amyloid β, the major component found in the amyloid plaques that are the hallmark of Alzheimer disease

Atorvastatin, Vaccine Trial Data Published

RESEARCH NEWS 2005-05-13 Research News A mixed bag of epidemiologic studies alternatively hold up and knock down the promise that widely prescribed cholesterol-lowering statin drugs might offer some protection against Alzheimer disease progression (see ARF related news story). La

New Lease on Life for Adult Stem Cells

RESEARCH NEWS 2005-05-06 Research News Adult stem cells in the intestine and skin of mice can be induced to multiply massively by the introduction of a master gene regulatory protein derived from embryonic stem cells. This finding, reported in the May 6 Cell by Rudy Jaenisch and

Mutant Huntingtin—Trojan Horse or Trebuchet?

RESEARCH NEWS 2005-05-05 Research News Mutant proteins that cause neurodegenerative disease, such as amyloid-β precursor protein, parkin, and huntingtin, are produced in many different neurons of the brain. So why do only certain subtypes of neurons degenerate in Alzheimer diseas

Coaxing Longevity from Catalase

RESEARCH NEWS 2005-05-05 Research News Mice live longer and show signs of delayed aging when they express the antioxidant enzyme catalase in their mitochondria, according to a report appearing today in Science online. The results of the study, by Peter Rabinovitch and his colleag

Aβ—Pinning Down Protofibrils

RESEARCH NEWS 2005-05-04 Research News Amyloid-β (Aβ) comes in many forms, including monomers, oligomers, protofibrils, and fibrils. Protofibrils have emerged as perhaps the most toxic form of the peptide (see ARF related news story and ARF news story), but because these species

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