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RESEARCH NEWS 2005-08-13 Research News The progressive shortening of telomeres, those DNA caps that protect the ends of chromosomes, limits the lifespan of dividing cells. When telomeres get too short, the cells stop replication and senesce. But these guardians of genome integrit
RESEARCH NEWS 2005-08-05 Research News Is it Alzheimer disease or just old age? What senior hasn’t thought as much while searching for misplaced car keys or trying to remember a favorite cousin’s daughter’s name? For clinicians, telling the difference is critically important, in
RESEARCH NEWS 2005-08-04 Research News Problems with the amyloid hypothesis notwithstanding, knowing where amyloid-β (Aβ) plaques form might be key to developing strategies for clearing them from the brains of those with Alzheimer disease (AD). In this month’s American Journal of
RESEARCH NEWS 2005-08-04 Research News Functional magnetic resonance imaging (fMRI) has the enormous potential to pinpoint neuronal damage in almost any part of the brain and could play an important part in the fight against Alzheimer disease (AD). But the technique remains sligh
RESEARCH NEWS 2005-08-01 Research News In life, you wouldn’t trust a child to do an adult’s job. In the brain, the same might be true. While the mature form of brain-derived neurotrophic factor (BDNF) may stimulate long-term potentiation (LTP), or the strengthening of synaptic co
RESEARCH NEWS 2005-07-29 Research News The cyclin-dependent kinase Cdk5 is a popular target for drug developers aiming to treat a number of neurodegenerative disorders, including Parkinson (see ARF related news story) and Alzheimer (AD) diseases. In AD, the kinase has been implic
RESEARCH NEWS 2005-07-29 Research News The allure of stem cells lies in their potential to treat a plethora of human degenerative diseases, including neurologic disorders such as Alzheimer and Parkinson diseases. However, realizing this potential requires taming the little dynamo
RESEARCH NEWS 2005-07-25 Research News The job description of presenilins (PS) in the business of neuron health and disease may be getting more complicated. Besides their role—as the catalytic core of γ-secretase—in amyloid-β (Aβ) peptide production, these proteins also regulate
RESEARCH NEWS 2005-07-22 Research News According to the overflowing bathtub analogy, either a blocked drain (not enough clearance), an oversized faucet (too much production), or a combination, contributes to the accumulation of amyloid-β (Aβ) peptides in the Alzheimer disease (AD
RESEARCH NEWS 2005-07-20 Research News Mouse models of Alzheimer disease based on overexpression of Aβ precursor protein (AβPP) may be run-of-the-mill these days, but how do we get to the kernel of the pathology? Is it just Aβ, or do the AβPP intracellular domains and the soluble
RESEARCH NEWS 2005-07-19 Research News The amyloid-β (Aβ) peptide is a destroyer of synapses, and its attack on neurotransmission is blamed for devastating memory loss experienced in Alzheimer disease. Now, two new studies suggest that Aβ’s initial assault is aimed squarely at sy
RESEARCH NEWS 2005-07-15 Research News In Alzheimer and some other neurodegenerative diseases, the microtubule-associated protein tau weaves a web of neurofibrillary tangles (NFTs) that might be toxic to neurons. But alternative interpretations suggest that NFTs, by sequestering
RESEARCH NEWS 2005-07-15 Research News In today’s Science, an international team of collaborators, led by Thomas Prolla at the University of Wisconsin, reports that accumulation of mutations in the mitochondrial genome may play a significant role in the aging process. This may co
RESEARCH NEWS 2005-07-15 Research News Analysis of growth rings from pine trees in Sweden shows that the proliferation of atomic tests in the 1950s and 1960s led to an explosion in levels of atmospheric carbon 14. Now, Jonas Frisen and colleagues at the Karolinska Institute in St
RESEARCH NEWS 2005-07-13 Research News Depending on how you slice the epidemiological pie, the use of cholesterol-lowering statins could appear to decrease, increase, or do nothing to the risk of developing Alzheimer disease, says a study published this week in the Archives of Ne
