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RESEARCH NEWS 2006-01-21 Research News Last week, the journal Science formally retracted two stem cell papers published by Woo Suk Hwang and colleagues at Seoul National University in the Republic of Korea. In the first paper, published in February 2004, Hwang and colleagues purp
RESEARCH NEWS 2006-01-20 Research News Raging autoimmune T cells were fingered as the culprits in the toxicity of the failed first-generation Alzheimer disease (AD) vaccine. Even so, one research group suggests that some alleged immune attackers could turn out to have a softer, m
RESEARCH NEWS 2006-01-20 Research News The Institute for the Study of Aging (ISOA), Ltd. has changed its name to the Alzheimer’s Drug Discovery Foundation (ADDF). The new name was selected to better reflect the foundation's mission as a public charity dedicated to accelerati
RESEARCH NEWS 2006-01-16 Research News Reduced activity of p21-activated kinase (PAK) may cause the synaptic defects that leave Alzheimer patients with poor memory and cognitive skills. That is the conclusion of a paper appearing in January 14 Nature Neuroscience online. Greg Col
RESEARCH NEWS 2006-01-13 Research News As the roster of substrates for the γ-secretase protease continues to swell, the presenilin (PS) proteins seem to be popping up everywhere. Now, Hui Zheng and colleagues from Baylor College of Medicine in Houston, Texas, report they’ve spott
RESEARCH NEWS 2006-01-12 Research News The drug memantine is a safe and effective therapy that helps patients suffering from moderate to severe Alzheimer disease for up to a year. However, evidence that the drug might slow the underlying pathology is weak. These are the two main
RESEARCH NEWS 2006-01-09 Research News The word "plasticity" means different things to different people. One of its common uses refers to the inherent ability of neuronal circuits to change and adapt to their environment. But scratch neuroscientists deep enough and they
RESEARCH NEWS 2006-01-07 Research News A paradox has plagued Alzheimer disease (AD) researchers for quite some time: People with AD have less Aβ42 in their cerebrospinal fluid (CSF) than do healthy individuals. This seems to fly in the face of the amyloid cascade hypothesis, whic
RESEARCH NEWS 2006-01-07 Research News The genetic expansion of internal polyglutamine sequences in several proteins renders them toxic to neurons in unexplained ways. Two new papers tie this polyGlu toxicity to the process of gene transcription in slightly different ways. In the
RESEARCH NEWS 2005-12-27 Research News Ever since encephalitis halted development of Elan’s active vaccine for Alzheimer disease (see ARF related news story), researchers have been racing to find a better alternative. Passive immunotherapy, the administration of antibodies rather
RESEARCH NEWS 2005-12-23 Research News In amyotrophic lateral sclerosis (ALS), motor neurons in the spinal cord and central nervous system die off for unknown reasons, causing creeping paralysis and, eventually, death. Mutations in the superoxide dismutase 1 gene (SOD1) are respo
CONFERENCE COVERAGE 2005-12-23 Conference Coverage Erythropoietin (EPO), produced by the kidney in response to low serum oxygen, is a major stimulant for red blood cell production. Though this glycoprotein has only been medically approved for the treatment of anemia, there are indicati
RESEARCH NEWS 2005-12-22 Research News Today, a study summarized in our SfN Conference News appeared in Neuron. First author John Cirrito, working with Dave Holtzman, Steven Paul, and colleagues at Washington University in St. Louis, Missouri, and Lilly Research Laboratories in I
RESEARCH NEWS 2005-12-22 Research News The oracle at Delphi had legendary powers of foresight. But would the prophetess have predicted a staggering 81 million cases of dementia worldwide by 2040? Probably not. That onus falls on Cleusa Ferri, from King’s College, London, and coll
RESEARCH NEWS 2005-12-20 Research News For the first time, researchers have identified duplications of the amyloid precursor protein (APP) gene locus as the cause of early onset Alzheimer disease in five families. The findings, from the laboratory of Dominique Campion of INSERM i
