6124 RESULTS
Sort By:
RESEARCH NEWS 2006-05-08 Research News Updated 1/30/2007 — Note by Alzforum Editor: The Doglio et al. paper has been retracted at the request of the authors. According to the authors, several of the figures were found to contain serious inaccuracies and no longer support the maj
RESEARCH NEWS 2006-05-04 Research News They say that the best things come in small packages. That sentiment may sum up some new approaches to Aβ immunotherapy. In previous meeting coverage we described how smaller Aβ antigens developed by Cynthia Lemere and colleagues may avoid p
RESEARCH NEWS 2006-05-01 Research News An active social life can stave off dementia in the elderly, but just how this works is not clear. Does having lots of friends and a full calendar actually retard the accumulation of plaques and tangles, and in that way preserve brain functi
RESEARCH NEWS 2006-04-30 Research News Happy mice, raised in cages filled with toys and exercise wheels, are better learners and show less anxiety than their less privileged littermates housed in standard bare cage conditions. Happy mice also display more neurogenesis in their hi
RESEARCH NEWS 2006-04-26 Research News In this week’s PNAS online, researchers at Dennis Selkoe’s lab at Harvard University, and Huilin Li’s lab at Brookhaven National Laboratory, Upton, New York, report the 3D structure of purified γ-secretase. Minji Kim, Alice Lu, and Rudy Tanz
RESEARCH NEWS 2006-04-26 Research News A study first reported from the Society for Neuroscience annual meeting last November has just been published in the April 19 Journal of Neuroscience. Gunnar Gouras and colleagues at Weill Medical College of Cornell University in New York Ci
RESEARCH NEWS 2006-04-26 Research News Recently, the Whitehead Institute for Biomedical Research in Cambridge, Massachusetts, hosted reporters for a day of talks on the promises and pitfalls of embryonic stem cell research and somatic cell nuclear transfer (aka human cloning). Wi
RESEARCH NEWS 2006-04-24 Research News For those of us tinkering with diet to achieve better health and stave off Alzheimer disease, new research in the April Annals of Neurology provides a possible recipe for success—namely, the Mediterranean diet. The diet—lots of fruits, veget
RESEARCH NEWS 2006-04-22 Research News When it comes to cleaning house, neurons are no slouches. Considering the number of neurodegenerative diseases that are triggered by the accumulation of protein garbage, it is clear that these cells cannot tolerate messes. For quick pickups,
CONFERENCE COVERAGE 2006-04-21 Conference Coverage By Minji Kim, Alice Lu, and Rudy Tanzi. David Holtzman, Washington University, St. Louis, Missouri, discussed the roles of ApoE and its three major isoforms—ε2, 3, and 4—on Aβ aggregation and clearance in FAD mutant APP mice expressing
CONFERENCE COVERAGE 2006-04-21 Conference Coverage By Minji Kim, Alice Lu, and Rudy Tanzi. Animal Models and Therapeutics Cynthia Lemere, Brigham and Women’s Hospital, Boston, discussed the Aβ vaccine approach to AD and progress toward developing a potential vaccine for AD that is both
RESEARCH NEWS 2006-04-19 Research News By Minji Kim, Alice Lu, and Rudy Tanzi. Lester Binder, Northwestern University, Chicago, Illinois, described the changes in tau conformation that correlate with the stages of neurofibrillary tangle (NFT) formation. Two distinct conformations
CONFERENCE COVERAGE 2006-04-19 Conference Coverage By Minji Kim, Alice Lu, and Rudy Tanzi. Donald Price, Johns Hopkins University, Baltimore, presented results of BACE knockout mouse studies. By filter trap and immunostaining methods, he showed that the BACE-/- mouse had no Aβ plaques
RESEARCH NEWS 2006-04-18 Research News Mutations in mitochondrial DNA (mtDNA) accumulate in aging and Alzheimer disease, but their impact on cell physiology has been open to debate. With thousands of copies of the mitochondrial genome per cell, the fraction of organelles afflicte
CONFERENCE COVERAGE 2006-04-17 Conference Coverage By Minji Kim, Alice Lu, and Rudy Tanzi. The third day of the meeting started with a session on presenilin and γ-secretase. Dennis Selkoe, Harvard Medical School, addressed the three principal stages of the life of Aβ: production, degra
