IFITM3 Forges Link Between Neuroinflammation and Aβ Production

RESEARCH NEWS 2020-09-03 Research News Neuroinflammation and Aβ deposition are two hallmarks of AD, and now, a study published September 3 in Nature is forging an alluring mechanistic link between them. Researchers led by Yueming Li at Memorial Sloan Kettering Cancer Center in ...

Global Genetics Symposium Starts Today

COMMUNITY NEWS 2020-09-01 Community News Trying out a new conference format in this pandemic era, the Alzheimer’s Disease Genetics Global Symposium starts September 1 and will run on demand through much of the month. For three weeks, registrants can view presentations as they ...

First Primate Model of Familial AD: Marmosets with Presenilin Mutation

RESEARCH NEWS 2020-08-29 Research News Mice fail to model many aspects of Alzheimer’s disease. Could monkeys capture the disease more fully? In a preprint posted to bioRXiv on August 24, researchers led by Takaomi Saido, RIKEN Center for Brain Science, Wako, and Erika Sasaki, ...

Molecular Structure of LRRK2 Gives Clues to Parkinson’s

RESEARCH NEWS 2020-08-28 Research News For the first time, researchers have solved the molecular structure of LRRK2, a major risk factor for Parkinson’s and autoimmune diseases. Structural biologists at the University of California, San Diego, used innovative methods to provide ...

With Tau in Synapses, NO Neurovascular Coupling

RESEARCH NEWS 2020-08-21 Research News When too much tau invades dendrites, synaptic signaling goes haywire. Now, researchers led by Costantino Iadecola at Weill Cornell Medical College, New York, accuse this mislocalized tau of disrupting neurovascular coupling as well. In the ...

Tunneling Nanotubes—How Pericytes Control Blood Flow

RESEARCH NEWS 2020-08-19 Research News In the healthy central nervous system, blood flows where neurons need it most. Now, researchers led by Adriana Di Polo at the University of Montreal help explain why. In the August 12 Nature, they describe a new mechanism for fine control of ...

Can Loss of a Single Protein Domain Cause ‘Alzheimer’s’ in Mice?

RESEARCH NEWS 2020-08-14 Research News Though it carries nary a human transgene, a new mouse model developed many of the hallmark features of Alzheimer’s disease, according to a study published August 14 in Science Advances. Mice deficient in the WD domain of the autophagy ...

Klotho VS Variant Preserves Memory by Preventing Tangles

RESEARCH NEWS 2020-08-14 Research News Researchers are beginning to uncover genetic factors that modify the ability of amyloid plaques to spur tau pathology. Now, scientists led by Michael Ewers at Ludwig-Maximilians University, Munich, add a longevity gene into the mix. In a ...

At AAIC, Hints of Target Engagement for Some Drug Candidates

CONFERENCE COVERAGE 2020-08-12 Conference Coverage This year’s virtual Alzheimer’s Association International Conference featured no new efficacy data from large clinical trials, but there were some snippets of news from early phase studies. CT1812 by Cognition Therapeutics (CogRx) ...

Umibecestat-Driven Cognitive Decline Is Reversible

CONFERENCE COVERAGE 2020-08-12 Conference Coverage At this year’s virtual Alzheimer’s Association International Conference, researchers from Novartis and the Banner Alzheimer’s Institute presented highly anticipated follow-up data from the massive Generation 1 and 2 Phase 3 trials. ...

FDA Accepts Aducanumab Application for Priority Review

RESEARCH NEWS 2020-08-08 Research News The fate of aducanumab now rests in the hands of regulators at the U.S. Food and Drug Administration (FDA). Biogen of Cambridge, Massachusetts, and Eisai Co. Ltd., Tokyo, announced on August 7 that the agency had accepted its Biologics ...

Heart Health Is Brain Health, and It Starts in Your 20s

CONFERENCE COVERAGE 2020-08-07 Conference Coverage Having established that poor cardiovascular health in midlife increases the risk of cognitive decline and dementia as a person ages, scientists are now pushing to see if the same relationship might hold true even earlier in life. ...

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