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Unequal: Some Tau Haplotypes Carry More Risk Than Others

RESEARCH NEWS 2019-03-22 Research News Scientists have known for years that the common H1 haplotype of the tau gene MAPT somehow raises a person’s risk of the rare neurodegenerative disorder progressive supranuclear palsy (PSP). It does so by more than fivefold, similar to what ...

Randall Bateman Wins Potamkin Prize

COMMUNITY NEWS 2019-03-22 Community News The 2019 Potamkin Prize for Research in Pick’s, Alzheimer’s and Related Diseases goes to Randall Bateman, Washington University, St. Louis. Bateman is being recognized for his work on the underlying biology of AD and for his commitment to ...

NIH Summit Sets Agenda for AD-Related Dementias

CONFERENCE COVERAGE 2019-03-22 Conference Coverage A busy hub of subcommittee meetings and brainstorming sessions, the Alzheimer's Disease-Related Dementias Summit 2019, held March 14–15 at the National Institutes of Health, Bethesda, Maryland, articulated research priorities for ...

Getting to Go: GAP-Net Sets Sight on Faster Start

CONFERENCE COVERAGE 2019-03-22 Conference Coverage In their grand project to hasten the start-up of therapy trials, the Global Alzheimer’s Platform trial network (GAP-Net) is looking to unclog procedural bottlenecks. Part 1 of this report of the GAP-Net Site Optimization conference, ...

In Year Three, GAP Trial Network Is Starting to Hum

CONFERENCE COVERAGE 2019-03-21 Conference Coverage Outside the daffodils and forsythia were blooming, but the group assembled in Nashville, Tennessee, hardly took notice. At the GAP-Net Site Optimization Conference, held February 27–March 1, representatives of 61 academic and private ...

Traumatic Tau: Filaments from CTE Share Distinct Structure

RESEARCH NEWS 2019-03-21 Research News Whether sustained on the field or in the ring, repeated blows to the head result in a distinctive strain of tau filaments in the brain. In the March 20 Nature, researchers led by Sjors Scheres and Michel Goedert of the MRC Laboratory of ...

Biogen/Eisai Halt Phase 3 Aducanumab Trials

RESEARCH NEWS 2019-03-21 Research News Today, Biogen and Eisai announced they would terminate the Phase 3 ENGAGE and EMERGE trials of aducanumab for early Alzheimer’s disease. A futility analysis run by an independent data-monitoring committee concluded that that trials would not ...

Is Klotho’s Partner FGF23 a Cognition Protein?

RESEARCH NEWS 2019-03-20 Research News The longevity gene klotho keeps memory keen, but how? New research raises the possibility that it might influence cognition through its signaling partners FGF23 and the fibroblast growth factor (FGF) receptor. In the March 7 eNeuro, ...

Flash! Beep! Gamma Waves Stimulate Microglia, Memory

RESEARCH NEWS 2019-03-15 Research News New data expands on the benefits of gamma wave therapy previously reported in mouse models of Alzheimer’s disease. Researchers led by MIT scientist Li-Huei Tsai report that sound can entrain gamma oscillations in both the auditory cortex and ...

In New Study, Diet During Midlife Not Linked to Dementia

RESEARCH NEWS 2019-03-14 Research News If dementia is all you are worried about, a study of British civil servants suggests you may as well double down on pork pies and fish and chips. In the March 12 JAMA, researchers led by Tasnime Akbaraly at Université Montpellier, France, ...

Deep Blue for Aβ Blood Test?

RESEARCH NEWS 2019-03-13 Research News In the March 11 Scientific Reports, researchers led by Noel Faux at IBM Research Australia in Southbank propose yet another blood test for Alzheimer’s disease, this one based on simple immunoassays. The scientists used machine learning to ...

CRISPR Suppresses BACE1 and Plaques in Mice

RESEARCH NEWS 2019-03-13 Research News Researchers have enlisted CRISPR technology to edit Alzheimer’s disease-related genes in isolated cells and in wild-type mice. The March 11 Nature Neuroscience now offers a glimpse of what CRISPR can do in mouse models of adult amyloidosis. ...

More Evidence for Distinct TDP-43 Droplets

RESEARCH NEWS 2019-03-12 Research News A paper published March 5 in Neuron takes a subcellular look at the biology of TDP-43 aggregation, a feature of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Alzheimer’s disease. The authors, led by Sandrine Da Cruz ...

Dementia Researchers Commend FDA Crackdown on Supplement Hype

COMMUNITY NEWS 2019-03-10 Community News Purported miracle medicines have always been with us. In the 1800s, traveling salesmen hawked cure-all elixirs. Nowadays, companies peddle myriad supplements on the internet, often with spurious claims that they are “scientifically” proven ...

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