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ARIAS: Zooming in On Eye-based Biomarkers for Alzheimer’s

CONFERENCE COVERAGE 2019-04-30 Conference Coverage Have biomarkers for preclinical Alzheimer’s disease been staring us in the face all along, and we just did not see them? Recent studies report a plethora of changes in the eye as Aβ pathology emerges in the brain. Dwindling retinal ...

Spitting, Sniffing: Is This How We Will Dx Parkinson’s?

CONFERENCE COVERAGE 2019-04-30 Conference Coverage The quest for a noninvasive diagnostic test is leading Parkinson’s scientists to unlikely places. One is inside the mouth. At the 14th International Conference on Alzheimer’s and Parkinson’s Diseases in Lisbon, Portugal, Giorgio ...

Chimeric Mice: Can They Model Human Microglial Responses?

CONFERENCE COVERAGE 2019-04-26 Conference Coverage Microglia are finicky. Take them out of their normal environment and they have a personality meltdown. They dramatically change gene expression and just about turn into a different type of cell. How, then, to study human microglia in a ...

Light Is Alright: Mild Physical Activity Comes With Larger Brain

RESEARCH NEWS 2019-04-26 Research News Current health guidelines encourage people to hit the gym or go for a jog several times per week, but a new study suggests that engaging in much lighter forms of physical activity could bestow benefits upon the brain. In a paper published ...

New Money to Spur Tech Search for AD Biomarkers

COMMUNITY NEWS 2019-04-26 Community News There has been a lot of excitement about the potential of a blood test for Alzheimer’s disease. But what if an even less invasive test could predict, diagnose, or track disease, and speed trial recruitment? With an influx of $15 million ...

Older Children with Spinal Muscular Atrophy Improve on Nusinersen

RESEARCH NEWS 2019-04-24 Research News Children with later-onset spinal muscular atrophy benefited from three years of treatment with the anti-sense oligonucleotide nusinersen, according to a paper in today’s Neurology. Motor function either improved or stabilized in kids aged 2 ...

Could Greasing the Wheels of Lipid Processing Treat Alzheimer’s?

CONFERENCE COVERAGE 2019-04-24 Conference Coverage ApoE4 impairs how the brain handles lipids. At the 14th International Conference on Alzheimer’s and Parkinson’s Diseases, held March 27–31 in Lisbon, Portugal, researchers argued that this effect of AD’s biggest risk gene is important ...

Could CD33 Be the Microglial Target for Stimulating Phagocytosis?

CONFERENCE COVERAGE 2019-04-23 Conference Coverage Much of the research on microglia in Alzheimer’s disease has focused on the TREM2 receptor (see Part 4 of this series). But other microglial receptors play a hand in age- and injury-related activation as well (e.g.,  Apr 2019 news on ...

Parsing How Alzheimer’s Genetic Risk Works Through Microglia

CONFERENCE COVERAGE 2019-04-23 Conference Coverage Much of the genetic risk of Alzheimer’s disease plays out in microglia. But exactly how do risk variants change these cells? At the 14th International Conference on Alzheimer’s and Parkinson’s Diseases, held March 27–31 in Lisbon, ...

APP Upp: Mutation Nixes Six Amino Acids from Aβ, Spurs Aggregation

CONFERENCE COVERAGE 2019-04-20 Conference Coverage Thirty missense mutations in amyloid precursor protein  are known to cause autosomal-dominant Alzheimer’s disease. Now, scientists at Uppsala University, Sweden, have identified a deletion in the APP gene that does the same thing. At ...

Electrode Detects Aβ Aggregates in Alzheimer’s Plasma

RESEARCH NEWS 2019-04-19 Research News In the April 17 Science Advances, researchers proffer a new technique for detecting plasma Aβ. Scientists led by Kyo Seon Hwang at Kyung Hee University, Seoul, and YoungSoo Kim at Yonsei University, Incheon, both in the Republic of Korea, ...

Expression, Expression, Expression—Time to Get on Board with eQTLs

CONFERENCE COVERAGE 2019-04-19 Conference Coverage Next-generation genetic analysis has opened the floodgates to a wave of new gene discovery. Whole-exome and-genome sequencing have nearly doubled the number of previously known Alzheimer’s genes (see Part 1 of this story). But modern ...

At AD/PD Conference, New Alzheimer’s Genes Reinforce Known Pathways

CONFERENCE COVERAGE 2019-04-19 Conference Coverage Genome-wide association studies have turned up some 30 loci linked to Alzheimer’s, yet GWAS still left much of the disease’s heritability unexplained. To find the remaining genes, geneticists have turned to whole-genome and whole-exome ...

Amid Brexhaustion, U.K. DRI Marches On, Seeks Innovation Director

RESEARCH NEWS 2019-04-18 Research News In the two years since Britain’s Dementia Research Institute was launched, the country, and with it the fledgling institute, has been tossed about by the roiling chaos of Brexit. Now, despite it all, the DRI is striking out to transform ...

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