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Antibodies Against Microglial Receptors TREM2 and CD33 Head to Trials

CONFERENCE COVERAGE 2019-05-10 Conference Coverage As neuroinflammation becomes ever more deeply implicated in Alzheimer’s disease, therapies targeting this process are starting to enter clinical trials. At the 14th International Conference on Alzheimer’s and Parkinson’s Diseases, held ...

Drug Reported to Help Alzheimer’s Patients Sleep Better

CONFERENCE COVERAGE 2019-05-10 Conference Coverage Nearly half of people with Alzheimer’s can’t sleep at night, waking up more often and staying awake longer than others their age. This causes nighttime wandering, and worsens cognition and depression. Despite the burden for both ...

Longitudinal Tau-PET Links Aβ to Subsequent Rise in Cortical Tau

RESEARCH NEWS 2019-05-09 Research News The growth of tau tangle pathology in the brain’s cortex only happens in people who also have Aβ plaques, and it correlates with cognitive decline. These conclusions are supported by the largest, multicenter, longitudinal tau PET study ...

Amyloid-PET Results Lead Some to Ponder Assisted Death in Future

RESEARCH NEWS 2019-05-09 Research News As Alzheimer’s disease prevention studies are seeking cognitively healthy but biomarker-positive volunteers, researchers must grapple with ethical implications of divulging amyloid status to symptom-free people. What is the psychological ...

Off-Balance Endocytosis Lays Groundwork for Disease

CONFERENCE COVERAGE 2019-05-03 Conference Coverage Endocytosis is implicated in Alzheimer’s pathogenesis, because the continuous swallowing up of proteins from the cell surface and packaging them into little organelles brings the amyloid precursor protein (APP) into contact with the ...

Plasma NfL Goes the Distance in Alzheimer’s

RESEARCH NEWS 2019-05-02 Research News Damaged axons spill their guts, and the debris eventually makes its way into the bloodstream. Now, scientists tracking one such neuron-derived protein are moving closer to a blood test for neurodegeneration in Alzheimer’s disease. In a ...

Introducing LATE—A Common TDP-43 Proteinopathy that Strikes After 80

RESEARCH NEWS 2019-05-01 Research News An 86-year-old woman develops classic amnestic symptoms of Alzheimer’s disease in her last years of life, but upon autopsy, her brain bears but a modest burden of Aβ plaques and tau tangles. Instead, TDP-43 inclusions crowd her limbic ...

On The Docket at AD/PD: The Many Crimes of ApoE4

CONFERENCE COVERAGE 2019-05-01 Conference Coverage Despite years of study, ApoE still has secrets to give up. At the 14th International Conference on Alzheimer’s and Parkinson’s Diseases, held March 27–31 in Lisbon, Portugal, researchers indicted ApoE4 on several fronts. They charged ...

ARIAS: Zooming in On Eye-based Biomarkers for Alzheimer’s

CONFERENCE COVERAGE 2019-04-30 Conference Coverage Have biomarkers for preclinical Alzheimer’s disease been staring us in the face all along, and we just did not see them? Recent studies report a plethora of changes in the eye as Aβ pathology emerges in the brain. Dwindling retinal ...

Spitting, Sniffing: Is This How We Will Dx Parkinson’s?

CONFERENCE COVERAGE 2019-04-30 Conference Coverage The quest for a noninvasive diagnostic test is leading Parkinson’s scientists to unlikely places. One is inside the mouth. At the 14th International Conference on Alzheimer’s and Parkinson’s Diseases in Lisbon, Portugal, Giorgio ...

Chimeric Mice: Can They Model Human Microglial Responses?

CONFERENCE COVERAGE 2019-04-26 Conference Coverage Microglia are finicky. Take them out of their normal environment and they have a personality meltdown. They dramatically change gene expression and just about turn into a different type of cell. How, then, to study human microglia in a ...

Light Is Alright: Mild Physical Activity Comes With Larger Brain

RESEARCH NEWS 2019-04-26 Research News Current health guidelines encourage people to hit the gym or go for a jog several times per week, but a new study suggests that engaging in much lighter forms of physical activity could bestow benefits upon the brain. In a paper published ...

New Money to Spur Tech Search for AD Biomarkers

COMMUNITY NEWS 2019-04-26 Community News There has been a lot of excitement about the potential of a blood test for Alzheimer’s disease. But what if an even less invasive test could predict, diagnose, or track disease, and speed trial recruitment? With an influx of $15 million ...

Older Children with Spinal Muscular Atrophy Improve on Nusinersen

RESEARCH NEWS 2019-04-24 Research News Children with later-onset spinal muscular atrophy benefited from three years of treatment with the anti-sense oligonucleotide nusinersen, according to a paper in today’s Neurology. Motor function either improved or stabilized in kids aged 2 ...

Could Greasing the Wheels of Lipid Processing Treat Alzheimer’s?

CONFERENCE COVERAGE 2019-04-24 Conference Coverage ApoE4 impairs how the brain handles lipids. At the 14th International Conference on Alzheimer’s and Parkinson’s Diseases, held March 27–31 in Lisbon, Portugal, researchers argued that this effect of AD’s biggest risk gene is important ...

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