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Biogen/Eisai Halt Phase 3 Aducanumab Trials

RESEARCH NEWS 2019-03-21 Research News Today, Biogen and Eisai announced they would terminate the Phase 3 ENGAGE and EMERGE trials of aducanumab for early Alzheimer’s disease. A futility analysis run by an independent data-monitoring committee concluded that that trials would not ...

Is Klotho’s Partner FGF23 a Cognition Protein?

RESEARCH NEWS 2019-03-20 Research News The longevity gene klotho keeps memory keen, but how? New research raises the possibility that it might influence cognition through its signaling partners FGF23 and the fibroblast growth factor (FGF) receptor. In the March 7 eNeuro, ...

Flash! Beep! Gamma Waves Stimulate Microglia, Memory

RESEARCH NEWS 2019-03-15 Research News New data expands on the benefits of gamma wave therapy previously reported in mouse models of Alzheimer’s disease. Researchers led by MIT scientist Li-Huei Tsai report that sound can entrain gamma oscillations in both the auditory cortex and ...

In New Study, Diet During Midlife Not Linked to Dementia

RESEARCH NEWS 2019-03-14 Research News If dementia is all you are worried about, a study of British civil servants suggests you may as well double down on pork pies and fish and chips. In the March 12 JAMA, researchers led by Tasnime Akbaraly at Université Montpellier, France, ...

Deep Blue for Aβ Blood Test?

RESEARCH NEWS 2019-03-13 Research News In the March 11 Scientific Reports, researchers led by Noel Faux at IBM Research Australia in Southbank propose yet another blood test for Alzheimer’s disease, this one based on simple immunoassays. The scientists used machine learning to ...

CRISPR Suppresses BACE1 and Plaques in Mice

RESEARCH NEWS 2019-03-13 Research News Researchers have enlisted CRISPR technology to edit Alzheimer’s disease-related genes in isolated cells and in wild-type mice. The March 11 Nature Neuroscience now offers a glimpse of what CRISPR can do in mouse models of adult amyloidosis. ...

More Evidence for Distinct TDP-43 Droplets

RESEARCH NEWS 2019-03-12 Research News A paper published March 5 in Neuron takes a subcellular look at the biology of TDP-43 aggregation, a feature of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Alzheimer’s disease. The authors, led by Sandrine Da Cruz ...

Dementia Researchers Commend FDA Crackdown on Supplement Hype

COMMUNITY NEWS 2019-03-10 Community News Purported miracle medicines have always been with us. In the 1800s, traveling salesmen hawked cure-all elixirs. Nowadays, companies peddle myriad supplements on the internet, often with spurious claims that they are “scientifically” proven ...

Does High Iron Push a Person With Pathology Into Dementia?

RESEARCH NEWS 2019-03-08 Research News Iron is an essential nutrient, but like any good thing, too much of it may do harm. According to an autopsy study published February 18 in Molecular Psychiatry, people who had had dementia and moderate to high burdens of plaques and tangles ...

Alzheimer’s Association Report Argues for Cognitive Screening

COMMUNITY NEWS 2019-03-08 Community News On March 5, the Alzheimer's Association released its annual Facts and Figures report, a compilation of the latest statistics on Alzheimer’s disease in the U.S. Besides summing up prevalence, mortality and morbidity, and costs of ...

Paper Alerts: Massive GWAS Studies Published

RESEARCH NEWS 2019-03-02 Research News On February 28 in Nature Genetics online, geneticists from the International Genomics of Alzheimer’s Project published the largest genome-wide association meta-analysis to date. Brian Kunkle, University of Miami Miller School of Medicine, ...

Stress Granules: No Incubator for Inclusions, After All?

RESEARCH NEWS 2019-03-01 Research News TDP-43 proteinopathy rears its ugly head in most patients with amyotrophic lateral sclerosis and nearly half of those with frontotemporal dementia, not to mention many cases of Alzheimer’s disease and traumatic brain injury. Still, it’s been ...

Take With a Grain of Salt: Mitigating Aβ Pathology With Sodium Rutin

RESEARCH NEWS 2019-03-01 Research News Want more evidence of the importance of microglia for Alzheimer’s disease? A study in the February 27 Science Advances suggests that spicing up the metabolism of these cells can tamp down Alzheimer’s pathology. Researchers led by Zengqiang ...

Rogue Gene Networks Track with Neurodegeneration Across Diseases

RESEARCH NEWS 2019-03-01 Research News A sporadic case of neurodegenerative disease likely represents the culmination of myriad gene-expression changes in the brain. How to make sense of the chaos, let alone restore order? In the January Nature Medicine, researchers led by Daniel ...

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