WHO Weighs in With Guidelines for Preventing Dementia

COMMUNITY NEWS 2019-05-17 Community News Many researchers and advocacy groups tout the benefits of a healthy lifestyle for preventing cognitive decline and dementia. Now the World Health Organization has weighed in, releasing a set of guidelines for lowering risk. The guidelines ...

Keep Your Enthusiasm? Scientists Process Brutal Trial Data

CONFERENCE COVERAGE 2019-05-16 Conference Coverage “There is a lot of bad news, but it’s useful bad news.” This line by Randy Bateman of Washington University, St. Louis, captured the mood at the AD/PD conference held March 27 to 31 in Lisbon, Portugal. Whereas in years past scientists ...

Forget Fibrils: Lewy Pathology Is More Lipid Than Protein

CONFERENCE COVERAGE 2019-05-10 Conference Coverage In Parkinson’s disease, abnormal deposits called Lewy bodies and Lewy neurites pop up in neurons and processes, respectively. In 1998, Maria Grazia Spillantini at the University of Cambridge identified α-synuclein as their major ...

Do Immune Cells Promote the Spread of α-Synuclein Pathology?

CONFERENCE COVERAGE 2019-05-10 Conference Coverage How does α-synuclein pathology spread? At the 14th International Conference on Alzheimer’s and Parkinson’s Diseases, held March 27–31 in Lisbon, Portugal, speakers said immune cells bear some of the blame. Markus Britschgi of Roche in ...

Antibodies Against Microglial Receptors TREM2 and CD33 Head to Trials

CONFERENCE COVERAGE 2019-05-10 Conference Coverage As neuroinflammation becomes ever more deeply implicated in Alzheimer’s disease, therapies targeting this process are starting to enter clinical trials. At the 14th International Conference on Alzheimer’s and Parkinson’s Diseases, held ...

Drug Reported to Help Alzheimer’s Patients Sleep Better

CONFERENCE COVERAGE 2019-05-10 Conference Coverage Nearly half of people with Alzheimer’s can’t sleep at night, waking up more often and staying awake longer than others their age. This causes nighttime wandering, and worsens cognition and depression. Despite the burden for both ...

Longitudinal Tau-PET Links Aβ to Subsequent Rise in Cortical Tau

RESEARCH NEWS 2019-05-09 Research News The growth of tau tangle pathology in the brain’s cortex only happens in people who also have Aβ plaques, and it correlates with cognitive decline. These conclusions are supported by the largest, multicenter, longitudinal tau PET study ...

Amyloid-PET Results Lead Some to Ponder Assisted Death in Future

RESEARCH NEWS 2019-05-09 Research News As Alzheimer’s disease prevention studies are seeking cognitively healthy but biomarker-positive volunteers, researchers must grapple with ethical implications of divulging amyloid status to symptom-free people. What is the psychological ...

Off-Balance Endocytosis Lays Groundwork for Disease

CONFERENCE COVERAGE 2019-05-03 Conference Coverage Endocytosis is implicated in Alzheimer’s pathogenesis, because the continuous swallowing up of proteins from the cell surface and packaging them into little organelles brings the amyloid precursor protein (APP) into contact with the ...

Plasma NfL Goes the Distance in Alzheimer’s

RESEARCH NEWS 2019-05-02 Research News Damaged axons spill their guts, and the debris eventually makes its way into the bloodstream. Now, scientists tracking one such neuron-derived protein are moving closer to a blood test for neurodegeneration in Alzheimer’s disease. In a ...

Introducing LATE—A Common TDP-43 Proteinopathy that Strikes After 80

RESEARCH NEWS 2019-05-01 Research News An 86-year-old woman develops classic amnestic symptoms of Alzheimer’s disease in her last years of life, but upon autopsy, her brain bears but a modest burden of Aβ plaques and tau tangles. Instead, TDP-43 inclusions crowd her limbic ...

On The Docket at AD/PD: The Many Crimes of ApoE4

CONFERENCE COVERAGE 2019-05-01 Conference Coverage Despite years of study, ApoE still has secrets to give up. At the 14th International Conference on Alzheimer’s and Parkinson’s Diseases, held March 27–31 in Lisbon, Portugal, researchers indicted ApoE4 on several fronts. They charged ...

ARIAS: Zooming in On Eye-based Biomarkers for Alzheimer’s

CONFERENCE COVERAGE 2019-04-30 Conference Coverage Have biomarkers for preclinical Alzheimer’s disease been staring us in the face all along, and we just did not see them? Recent studies report a plethora of changes in the eye as Aβ pathology emerges in the brain. Dwindling retinal ...

Spitting, Sniffing: Is This How We Will Dx Parkinson’s?

CONFERENCE COVERAGE 2019-04-30 Conference Coverage The quest for a noninvasive diagnostic test is leading Parkinson’s scientists to unlikely places. One is inside the mouth. At the 14th International Conference on Alzheimer’s and Parkinson’s Diseases in Lisbon, Portugal, Giorgio ...

Chimeric Mice: Can They Model Human Microglial Responses?

CONFERENCE COVERAGE 2019-04-26 Conference Coverage Microglia are finicky. Take them out of their normal environment and they have a personality meltdown. They dramatically change gene expression and just about turn into a different type of cell. How, then, to study human microglia in a ...

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