Beyond the Nucleus: TDP-43 Sticks Together, For Better or Worse

CONFERENCE COVERAGE 2018-12-01 Conference Coverage Similar to a newborn human, nascent RNA transcripts need a lot of coddling before they realize their purpose in life (that is, translation into protein). It takes a village of RNA-binding proteins to accomplish this. They see to the ...

Pig Model of ALS Mimics Human Disease

RESEARCH NEWS 2018-11-30 Research News In the November 21 Neurobiology of Disease, researchers led by Cristiano Corona, Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d’Aosta, Turin, Italy, characterize the ALS-like signs and symptoms seen in pigs that ...

Imaging Data Resurrects Abandoned Parkinson’s Gene Therapy

RESEARCH NEWS 2018-11-30 Research News Researchers often do not understand exactly how treatments produce benefits. Take a recent gene therapy for Parkinson’s disease. It was intended to dampen excess activity in the subthalamic nucleus, mimicking the effect of deep brain ...

Could an Aspirin a Day Keep Multiple Sclerosis at Bay?

RESEARCH NEWS 2018-11-29 Research News People take aspirin for pain, fever, and even in hopes of warding off a heart attack. Could this old, over-the-counter pill also help control multiple sclerosis? A November 27 report in Science Signaling suggests as much—in mice. Scientists ...

Which Are the Right Tests to Satisfy New FDA Guidance?

CONFERENCE COVERAGE 2018-11-27 Conference Coverage As researchers push toward testing Alzheimer’s drugs at presymptomatic stages, the hurdle before them—how to show efficacy and get a drug approved—looks different than before. In its February 2018 draft guidance for industry, the U.S. ...

Progranulin: A Mark of Worsening Alzheimer’s?

RESEARCH NEWS 2018-11-27 Research News Progranulin, a microglial protein typically associated with frontotemporal dementia, may also play a role in Alzheimer’s. That’s according to a November 27 paper in the EMBO Journal. Scientists led by Christian Haass, Ludwig-Maximilians ...

Could Rogue APP Variants Invade Genome of Individual Neurons?

RESEARCH NEWS 2018-11-21 Research News Multiple copies of the amyloid precursor gene crop up in adult neurons of the human brain, creating a heterogeneous neuronal landscape in a single person. This is especially true in brains from people with sporadic Alzheimer’s disease, but ...

Trial-Ready Cohorts Take Shape in Europe and U.S.

CONFERENCE COVERAGE 2018-11-20 Conference Coverage To speed up recruitment into Alzheimer’s trials, researchers have created innovative new platforms that establish trial-ready cohorts of people at early disease stages. The farthest along is the European Prevention of Alzheimer’s ...

Trials of Diabetes-Related Therapies: Mainly a Bust

CONFERENCE COVERAGE 2018-11-20 Conference Coverage This is Part 2 of a two-part story. Click here for Part 1. The highs and lows of diabetes-related therapies were on display at the Clinical Trials on Alzheimer’s Disease Conference, held October 24–27 in Barcelona, Spain. This time ...

Fits and Starts: Trial Results from the CTAD Conference

CONFERENCE COVERAGE 2018-11-20 Conference Coverage This is Part 1 of a two-part story. Click here for Part 2. As in years past, trial results offered up a mixed bag of goods and duds at the Clinical Trials on Alzheimer’s Disease Conference, held October 24–27 in Barcelona, Spain. In ...

How Does The NIA-AA Framework Measure Up Against Real Data?

CONFERENCE COVERAGE 2018-11-19 Conference Coverage This past spring, the National Institute on Aging and Alzheimer’s Association proposed a new research framework in an effort to nudge the field toward a biological definition of Alzheimer’s disease (Apr 2018 news). The framework ...

Not Just Motoneurons: Sensory Neurons Suffer Effects of ALS

RESEARCH NEWS 2018-11-16 Research News A cell biology study adds evidence that sensory neurons, not just motoneurons, take a direct hit in amyotrophic lateral sclerosis (ALS). Scientists led by Gregorio Valdez, Virginia Tech Carilion Research Institute, Roanoke, report that ...

Is NfL the New 'N' in A/T/N Classification of Alzheimer’s?

RESEARCH NEWS 2018-11-15 Research News Neurofilament light (NfL) measured in cerebrospinal fluid predicts mild cognitive impairment better than other CSF indicators of neurodegeneration, according to the November 12 JAMA Neurology. Scientists led by Michelle Mielke, Mayo Clinic, ...

Amyloid PET Aids Diagnosis. But Could CSF Do Just as Well?

CONFERENCE COVERAGE 2018-11-14 Conference Coverage Clinicians have been eagerly awaiting results of the enormous Imaging Dementia–Evidence for Amyloid Scanning  (IDEAS) study, which may determine whether amyloid scans will be covered by insurance. Preliminary findings previously ...

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