Anti-Agitation Drug Comes Up Short in Phase 3

RESEARCH NEWS 2019-10-03 Research News A drug being tested for its ability to calm agitation in Alzheimer’s disease provided no benefit in the TRIAD-1 Phase 3 trial, according to topline results announced by Avanir Pharmaceuticals on September 27 (see press release). The drug, ...

Frontal Metabolic Patterns Mark Behavioral Subtype of AD

RESEARCH NEWS 2019-09-28 Research News In a small percentage of people with Alzheimer’s disease, behavioral changes early on—such as a disregard for social norms or loss of empathy—can lead physicians to mistakenly diagnose behavioral variant frontotemporal dementia (bvFTD). How ...

“Runner Plasma” Jogs Neurogenesis, Quells Neuroinflammation in Mice

RESEARCH NEWS 2019-09-27 Research News Regular exercise infuses the blood with factors that benefit the brain, according to a manuscript posted on the bioRχiv preprint server on September 19. Researchers led by Tony Wyss-Coray of Stanford University reported that plasma taken ...

LRRK2 Mutation Fires Up Immune Response, Harms Brain

RESEARCH NEWS 2019-09-27 Research News The LRRK2 variant, G2019S, increases a person’s chances of getting Parkinson’s disease, but may help protect against infection, according to research in the September 25 Science Translational Medicine. Scientists led by Michael Schlossmacher ...

Mitochondrial Jetsam Spurs Neurodegeneration

RESEARCH NEWS 2019-09-24 Research News Mitochondrial fragments, jettisoned by stressed cells, create trouble for other cells, according to a study in the September 23 Nature Neuroscience. Researchers led by Daria Mochly-Rosen at Stanford University School of Medicine report that ...

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