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Dementia: Frailty Hastens It, Physical Activity Wards It Off

RESEARCH NEWS 2019-01-25 Research News How is it that some people can have a brain full of plaques and tangles, yet somehow fend off dementia? By way of explanation, the concept of cognitive reserve tends to come up and now, two new postmortem studies suggest that physical ...

Another Reason to Catch Some Zzzs: Sleep Regulates Tau Release

RESEARCH NEWS 2019-01-25 Research News As if we needed yet another reason to get a good night’s sleep. David Holtzman and colleagues at Washington University in St. Louis claim in the January 24 Science that tau in a person’s cerebrospinal fluid tapers off during sleep and spikes ...

Rocking Improves Sleep and Memory in Adults

RESEARCH NEWS 2019-01-25 Research News Rocking isn’t just for babies anymore—it can soothe slumbering adults, too. Two papers in the January 24 Current Biology online suggest that a gentle, rhythmic sway throughout the night promotes sleep and memory. In the first study, ...

BACE and γ-Secretase Form Mega-Complex that Processes APP

RESEARCH NEWS 2019-01-23 Research News The production of Aβ peptides from the amyloid precursor protein is a two-step affair: A first cut by the β-secretase (BACE) releases the extracellular portion of APP, leaving the C-terminal fragment (CTF) to find its way to γ-secretase for ...

Neurofilament in Blood Foretells Early Onset Alzheimer’s

RESEARCH NEWS 2019-01-21 Research News A paper published online today in Nature Medicine finds that in familial Alzheimer’s disease, blood levels of neurofilament light (NfL) rise 16 years before the predicted age of onset. Scientists led by Mathias Jucker, German Center for ...

Invasion of the Microtubules: Mutant Tau Deforms Neuronal Nuclei

RESEARCH NEWS 2019-01-19 Research News A paper in the January 15 Cell Reports suggests that tauopathies cause defects in nucleocytoplasmic transport. Scientists led by Rick Livesey, University College London, report that mutated tau gives rise to microtubules that prod neuronal ...

Deadline to Weigh In on New Biomarker Guidance Approaches

COMMUNITY NEWS 2019-01-18 Community News The development of biomarkers for Alzheimer’s and other neurodegenerative diseases is accelerating rapidly, with blood tests and new fluid and imaging markers on the horizon (Aug 2018 news; Nov 2018 news; Dec 2018 news). However, developers ...

Microtubule Regulator Connects TDP-43 to Axonal Dysfunction

RESEARCH NEWS 2019-01-18 Research News Nearly all cases of amyotrophic lateral sclerosis, and half of frontotemporal dementia ones, are marked by deposits of the RNA-binding protein TDP-43, yet researchers still have little idea how this pathology relates to neurodegeneration. ...

Could the Purported Muscle Exercise Hormone, Irisin, Jog Memory?

RESEARCH NEWS 2019-01-16 Research News Physical activity may improve cognition, and a paper in the January 8 Nature Medicine makes the case that a peptide shed from muscles during exercise might be responsible. Researchers led by Fernanda De Felice of Federal University of Rio De ...

First In Vivo Look at Amyloidosis Sparked by Dural Grafts

RESEARCH NEWS 2019-01-16 Research News Evidence for the transmission of Aβ seeds between people keeps accumulating. In the December 31 Annals of Neurology, researchers led by David Werring at University College London describe the cases of three adults with early onset cerebral ...

Secreted APP Binds GABA-B Receptors, Blocks Neurotransmitter Release

RESEARCH NEWS 2019-01-13 Research News Though Aβ tends to hog the research spotlight, scientists have steadily built a case for the importance of another APP fragment—secreted APP. Now, a paper in the January 11 Science explains how it tweaks synaptic transmission. Researchers ...

Tau, More than Aβ, Affects Sleep Early in Alzheimer’s

RESEARCH NEWS 2019-01-12 Research News Mounting evidence suggests a link between β-amyloid and disrupted sleep. Does the same hold true for tau? Yes, according to a paper published in the January 9 Science Translational Medicine. Using PET imaging, scientists led by Brendan Lucey ...

Do Alzheimer’s Biomarkers Vary by Race?

RESEARCH NEWS 2019-01-11 Research News Most of the research on Alzheimer’s biomarkers to date has been done in predominantly white populations, but a few small studies have hinted at possible racial differences. A paper in the January 7 JAMA Neurology supports this idea. ...

CryoEM γ-Secretase Structures Nail APP, Notch Binding

RESEARCH NEWS 2019-01-11 Research News Targeting the γ-secretase protease to prevent Alzheimer’s disease would require surgical precision to shut down Aβ42 production while allowing the non-pathogenic processing of amyloid precursor protein (APP) and other important substrates to ...

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