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Results from IDEAS Study Published

RESEARCH NEWS 2019-04-03 Research News Results of the Imaging Dementia–Evidence for Amyloid Scanning study were published April 2 in JAMA. IDEAS tested if amyloid PET affected the management or outcomes of dementia care. As reported previously on Alzforum, physicians changed ...

Compound Stimulates Lysosome, Clears Tau in Human Cells and Mice

RESEARCH NEWS 2019-03-29 Research News In the latest attempt to rid neurons of toxic tau, researchers are trying to harness and improve cells’ own clearance mechanisms. Researchers led by Kenneth Kosik, University of California, Santa Barbara, used a small molecule called ...

FDA Panel Rejects Neuronix Brain Stimulation Device

RESEARCH NEWS 2019-03-27 Research News An advisory panel appointed by the FDA was nearly unanimous in recommending yesterday that Yokneam, Israel-based Neuronix not be allowed to market its neuroAD Therapy System in the U.S. Approved for AD in Europe, Australia, and Israel, the ...

Neurogenesis Tapers In Older Brains, But Plummets in Alzheimer’s

RESEARCH NEWS 2019-03-25 Research News Does Alzheimer’s disease retard the birth of new neurons in the hippocampus? Data from mouse models suggests it might, but evidence from human brain has been lacking. In today’s Nature Medicine, researchers led by María Llorens-Martín at the ...

Unequal: Some Tau Haplotypes Carry More Risk Than Others

RESEARCH NEWS 2019-03-22 Research News Scientists have known for years that the common H1 haplotype of the tau gene MAPT somehow raises a person’s risk of the rare neurodegenerative disorder progressive supranuclear palsy (PSP). It does so by more than fivefold, similar to what ...

Randall Bateman Wins Potamkin Prize

COMMUNITY NEWS 2019-03-22 Community News The 2019 Potamkin Prize for Research in Pick’s, Alzheimer’s and Related Diseases goes to Randall Bateman, Washington University, St. Louis. Bateman is being recognized for his work on the underlying biology of AD and for his commitment to ...

NIH Summit Sets Agenda for AD-Related Dementias

CONFERENCE COVERAGE 2019-03-22 Conference Coverage A busy hub of subcommittee meetings and brainstorming sessions, the Alzheimer's Disease-Related Dementias Summit 2019, held March 14–15 at the National Institutes of Health, Bethesda, Maryland, articulated research priorities for ...

Getting to Go: GAP-Net Sets Sight on Faster Start

CONFERENCE COVERAGE 2019-03-22 Conference Coverage In their grand project to hasten the start-up of therapy trials, the Global Alzheimer’s Platform trial network (GAP-Net) is looking to unclog procedural bottlenecks. Part 1 of this report of the GAP-Net Site Optimization conference, ...

In Year Three, GAP Trial Network Is Starting to Hum

CONFERENCE COVERAGE 2019-03-21 Conference Coverage Outside the daffodils and forsythia were blooming, but the group assembled in Nashville, Tennessee, hardly took notice. At the GAP-Net Site Optimization Conference, held February 27–March 1, representatives of 61 academic and private ...

Traumatic Tau: Filaments from CTE Share Distinct Structure

RESEARCH NEWS 2019-03-21 Research News Whether sustained on the field or in the ring, repeated blows to the head result in a distinctive strain of tau filaments in the brain. In the March 20 Nature, researchers led by Sjors Scheres and Michel Goedert of the MRC Laboratory of ...

Biogen/Eisai Halt Phase 3 Aducanumab Trials

RESEARCH NEWS 2019-03-21 Research News Today, Biogen and Eisai announced they would terminate the Phase 3 ENGAGE and EMERGE trials of aducanumab for early Alzheimer’s disease. A futility analysis run by an independent data-monitoring committee concluded that that trials would not ...

Is Klotho’s Partner FGF23 a Cognition Protein?

RESEARCH NEWS 2019-03-20 Research News The longevity gene klotho keeps memory keen, but how? New research raises the possibility that it might influence cognition through its signaling partners FGF23 and the fibroblast growth factor (FGF) receptor. In the March 7 eNeuro, ...

Flash! Beep! Gamma Waves Stimulate Microglia, Memory

RESEARCH NEWS 2019-03-15 Research News New data expands on the benefits of gamma wave therapy previously reported in mouse models of Alzheimer’s disease. Researchers led by MIT scientist Li-Huei Tsai report that sound can entrain gamma oscillations in both the auditory cortex and ...

In New Study, Diet During Midlife Not Linked to Dementia

RESEARCH NEWS 2019-03-14 Research News If dementia is all you are worried about, a study of British civil servants suggests you may as well double down on pork pies and fish and chips. In the March 12 JAMA, researchers led by Tasnime Akbaraly at Université Montpellier, France, ...

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