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Mutation in the Parkinson’s Gene DJ-1 Derails Splicing

RESEARCH NEWS 2020-09-12 Research News Pathogenic mutations within coding regions almost always change protein function. For a missense mutation in the DJ-1 gene that causes Parkinson’s disease, an entirely different mechanism may be at play. According to a study led by led by ...

Micro Nudge? Positive Phase 2 Results for ALS Combination Drug

RESEARCH NEWS 2020-09-11 Research News A combination drug that targets cellular stress nudged, ever so slightly, progression of amyotrophic lateral sclerosis in a Phase 2 trial. Researchers led by Sabrina Paganoni at Massachusetts General Hospital, Boston, reported the findings ...

In ALS and FTD, Two Different Routes to TDP-43 Aggregation

RESEARCH NEWS 2020-09-09 Research News Different genetic mutations can converge on the same downstream pathology. The C9ORF72 repeat expansion and progranulin haploinsufficiency both trigger the RNA-binding protein TDP-43 to abandon the nucleus and settle in cytoplasm. TDP-43 ...

CPTX—A Synaptic “Glue” Restores Memory in Alzheimer’s Model

RESEARCH NEWS 2020-09-04 Research News Neurexin proteins lie in the presynapse and pentraxins in the post, and never the twain shall meet. But what if they did? By designing a small protein that binds to both, researchers in Japan, Germany, and the U.K., have created an ...

IFITM3 Forges Link Between Neuroinflammation and Aβ Production

RESEARCH NEWS 2020-09-03 Research News Neuroinflammation and Aβ deposition are two hallmarks of AD, and now, a study published September 3 in Nature is forging an alluring mechanistic link between them. Researchers led by Yueming Li at Memorial Sloan Kettering Cancer Center in ...

Global Genetics Symposium Starts Today

COMMUNITY NEWS 2020-09-01 Community News Trying out a new conference format in this pandemic era, the Alzheimer’s Disease Genetics Global Symposium starts September 1 and will run on demand through much of the month. For three weeks, registrants can view presentations as they ...

First Primate Model of Familial AD: Marmosets with Presenilin Mutation

RESEARCH NEWS 2020-08-29 Research News Mice fail to model many aspects of Alzheimer’s disease. Could monkeys capture the disease more fully? In a preprint posted to bioRXiv on August 24, researchers led by Takaomi Saido, RIKEN Center for Brain Science, Wako, and Erika Sasaki, ...

Molecular Structure of LRRK2 Gives Clues to Parkinson’s

RESEARCH NEWS 2020-08-28 Research News For the first time, researchers have solved the molecular structure of LRRK2, a major risk factor for Parkinson’s and autoimmune diseases. Structural biologists at the University of California, San Diego, used innovative methods to provide ...

With Tau in Synapses, NO Neurovascular Coupling

RESEARCH NEWS 2020-08-21 Research News When too much tau invades dendrites, synaptic signaling goes haywire. Now, researchers led by Costantino Iadecola at Weill Cornell Medical College, New York, accuse this mislocalized tau of disrupting neurovascular coupling as well. In the ...

Tunneling Nanotubes—How Pericytes Control Blood Flow

RESEARCH NEWS 2020-08-19 Research News In the healthy central nervous system, blood flows where neurons need it most. Now, researchers led by Adriana Di Polo at the University of Montreal help explain why. In the August 12 Nature, they describe a new mechanism for fine control of ...

Can Loss of a Single Protein Domain Cause ‘Alzheimer’s’ in Mice?

RESEARCH NEWS 2020-08-14 Research News Though it carries nary a human transgene, a new mouse model developed many of the hallmark features of Alzheimer’s disease, according to a study published August 14 in Science Advances. Mice deficient in the WD domain of the autophagy ...

Klotho VS Variant Preserves Memory by Preventing Tangles

RESEARCH NEWS 2020-08-14 Research News Researchers are beginning to uncover genetic factors that modify the ability of amyloid plaques to spur tau pathology. Now, scientists led by Michael Ewers at Ludwig-Maximilians University, Munich, add a longevity gene into the mix. In a ...

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