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Paper Alert: Lipid Droplet-Filled Microglia Harm the Brain

RESEARCH NEWS 2020-01-21 Research News In the January 20 Nature Neuroscience, researchers led by Tony Wyss-Coray at Stanford University, Palo Alto, California, identify a microglial subtype that accumulates cytoplasmic lipid droplets. These fatty microglia show up in the aging ...

Human and Mouse Microglia React Differently to Amyloid

RESEARCH NEWS 2020-01-17 Research News Transgenic mice fail to capture many aspects of Alzheimer’s disease, and a new transcriptional study lays bare one reason. Brain cells in the two species, it turns out, respond quite differently to amyloidosis. In the January 13 Nature ...

Vascular Dysfunction Taxes Cognition, but Not Via Amyloid, AD

RESEARCH NEWS 2020-01-16 Research News Three new studies add to growing evidence that damaged blood vessels wreak havoc on the brain, but not by exacerbating Aβ deposition. One, published in JAMA Neurology on December 20, found no correlation between intracerebral atherosclerosis ...

Could New Glutamate Receptor Activators Treat Alzheimer’s?

RESEARCH NEWS 2020-01-16 Research News According to an article in the January 14 Cell Reports, boosting the activity of certain excitatory receptors in the brain calms epileptic activity and improves learning and memory in mouse models of disease. Jesse Hanson, Genentech Inc. in ...

Does Tau Kill Neurons by Way of Necroptosis?

RESEARCH NEWS 2020-01-15 Research News How do neurons die in Alzheimer’s disease? Perhaps by necroptosis, a form of programmed cell death triggered by inflammation. In the December Acta Neuropathologica, researchers led by Dietmar Thal, Bart De Strooper, and Sriram Balusu at KU ...

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