Can BACE2 Protect Against Amyloidosis?

RESEARCH NEWS 2020-02-18 Research News It may seem counterintuitive, but could BACE2 protect against amyloidosis, rather than contribute to it? This is the central question in a manuscript posted to bioRxiv. Non-amyloidogenic processing of APP, and Aβ peptides, by BACE2 may ...

CryoEM of CBD Tau Suggests Another Unique Protofibril

RESEARCH NEWS 2020-02-14 Research News Evidence continues to pile up that filaments of aggregated tau form unique strains in different tauopathies. Why is that? A paper published online in Cell on February 6 suggests that post-translational modifications help decide a filament’s ...

New Myelin Makes Memories, but Supply Wanes with Age

RESEARCH NEWS 2020-02-14 Research News While the vast majority of myelin sheaths in the brain are laid down early in life, a pair of new studies published February 10 in Nature Neuroscience reveal that a fresh supply of the fatty axonal conductor is required to establish and ...

Paper Alert: Phase 3 Trial Data Published on Sleep Aid Suvorexant

RESEARCH NEWS 2020-02-13 Research News Nighttime wakefulness and wandering are common symptoms in Alzheimer’s disease, but doctors hesitate to prescribe sleep-enhancing drugs because those have been linked to worsening cognition and falls. Results from a Phase 3 trial published ...

Topline Result for First DIAN-TU Clinical Trial: Negative on Primary

RESEARCH NEWS 2020-02-10 Research News DIAN participants and investigators today are grappling with difficult news. A topline analysis of the first Phase 2/3 clinical trial that the DIAN-TU trials platform mounted for carriers of dominantly inherited Alzheimer’s disease mutations ...

PET Tracer Detects Synapse Loss Across Alzheimer’s Brain

CONFERENCE COVERAGE 2020-02-07 Conference Coverage Part 1 of a 2-part story. A PET tracer that lights up synapses is able to detect a loss of connectivity across the Alzheimer’s brain, according to new research presented at the Human Amyloid Imaging conference, held January 15–17 in ...

Toxic α-Synuclein: Egged on by ApoE4, Thwarted by ApoE2?

RESEARCH NEWS 2020-02-07 Research News ApoE4’s rap sheet just grew longer. Not only does ApoE’s notorious allele accelerate Aβ and tau pathology, it also drives the toxic aggregation of α-synuclein, according to two studies published February 5 in Science Translational Medicine. ...

A Central Role for Prion Protein in Neurodegeneration?

RESEARCH NEWS 2020-02-06 Research News Like Aβ oligomers, soluble aggregates of tau and α-synuclein bind to cellular prion protein, poisoning neurons, according to a study published in Acta Neuropathologica. Using a standardized procedure to produce soluble aggregates of these ...

Paper Alert: Two ApoE2s Provide “Exceptional” Protection Against AD

RESEARCH NEWS 2020-02-05 Research News The few people who carry two copies of the ApoE2 allele are blessed with remarkable protection against Alzheimer’s disease, according to a study published February 3 in Nature Communications. While the E2 allele has long been known to hedge ...

Does Young-Onset Parkinson’s Arise in Lysosomes?

RESEARCH NEWS 2020-01-31 Research News One in 10 people with Parkinson’s start noticing signs of the disease between the ages of 20 and 50. Most have no family history, and few carry known autosomal-dominant PD mutations. Can induced pluripotent stem cell (iPSC) modeling help ...

Soccer Heading Has Greater Impact on Memory in ApoE4 Carriers

RESEARCH NEWS 2020-01-31 Research News Soccer players who repeatedly bonk their noggins against the ball have losses in episodic memory. The losses are subtle and likely unnoticeable. This subclinical effect is strongest in ApoE4 carriers, according to a study published January ...

Chaperone Stabilizer Fends Off Amyloid, Memory Loss in Mice

RESEARCH NEWS 2020-01-30 Research News Constipated endosomes are a hallmark of degenerating neurons in people with AD. Scientists blame crumbling retromers, complexes that normally flush proteins out of these little organelles. A study published January 22 in Molecular ...

In AD, Chaperones Congregate To Form a Therapeutic Target

RESEARCH NEWS 2020-01-30 Research News A new study reveals a sticky web of protein-protein interactions, centered on heat shock protein 90 (HSP90) and other chaperones, in the brains of people with AD. This network, not found in healthy tissue, appears to entangle a host of ...

Do World Trade Center Responders Get Early Onset Plaques and Tangles?

RESEARCH NEWS 2020-01-28 Research News Thousands of first responders who cleaned up the wreckage of the World Trade Center site developed long-term health problems such as post-traumatic stress disorder, respiratory diseases, and cancer. Now, emerging evidence suggests their work ...

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