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γ-Secretase Spotted Traveling Solo or in Pairs, Not in Big Groups

RESEARCH NEWS 2020-07-10 Research News CryoEM of frozen membranes has revealed its most intimate folds. Biochemistry of tissue extracts says it bundles up with other secretases. But how does γ-secretase, the all-important enzyme that cleaves Aβ42 from its precursor, truly behave ...

PET Tracer PI-2620 Detects 4R Tau Deposits

RESEARCH NEWS 2020-07-10 Research News Tau tracers have invigorated Alzheimer’s research, but they initially proved disappointing for other tauopathies. That is now changing, with at least two tracers, PI-2620 and APN-1607, that appear to bind specifically to the 4R tau deposits ...

Liver Enzyme Levitates with Exercise, Spurs Learning in Old Mice

RESEARCH NEWS 2020-07-10 Research News It’s no longer news that exercise tones the brain as well as the body, keeping cognition sharp with age and lowering the risk of Alzheimer’s disease. Exactly how this works remains murky, however. In today’s Science, researchers led by Saul ...

Biogen Asks FDA To Approve Aducanumab

RESEARCH NEWS 2020-07-08 Research News Biogen announced today that it had submitted a biologics license application to the U.S. Food and Drug Administration for aducanumab, a therapeutic antibody developed to clear amyloid plaques from the brain. The Cambridge, Massachusetts, ...

With IL-33, Neurons Tempt Microglia to Nibble At Synapses

RESEARCH NEWS 2020-07-07 Research News Synaptic connections in the brain are highly plastic, continuously forming and disconnecting to help enshrine new experiences into memories throughout life. A study published in Cell on July 1 describes a mechanism involved. Researchers led ...

Blood-Brain Barrier Surprise: Proteins Flood into Young Brain

RESEARCH NEWS 2020-07-02 Research News The blood-brain barrier keeps most plasma proteins out of the brain, but becomes leaky with age and in Alzheimer’s. Or so scientists thought. In the July 1 Nature, researchers led by Tony Wyss-Coray at Stanford University turn this idea on ...

Women and Men Differ in Their Genetic Risk for Alzheimer’s Progression

RESEARCH NEWS 2020-07-02 Research News Researchers are beginning to assess how genetic variation influences sex differences in Alzheimer’s disease. True, women who have an ApoE4 allele are more likely to develop Alzheimer’s than are male carriers, but what about the many other ...

Does a Stimulating Childhood Stem Amyloid Plaques in Golden Years?

RESEARCH NEWS 2020-07-02 Research News A childhood rich with intellectual stimulation may help the brain resist the onslaught of Alzheimer’s disease decades later, according to a study published June 29 in JAMA Neurology. Researchers led by David Bennett at Rush University ...

RBFOX1 Gene Tied to Amyloidosis in Preclinical Alzheimer’s

RESEARCH NEWS 2020-06-30 Research News Massive genome-wide association studies for Alzheimer’s disease have primarily correlated genetic variants with clinical diagnosis, a rubric that is fraught with uncertainty. In a GWAS published June 22 in JAMA Neurology, researchers led by ...

Too Phatal: How Microglia, Astrocytes Snuff Out Dying Neurons

RESEARCH NEWS 2020-06-26 Research News Conventional wisdom holds that microglia are the main phagocytes of the brain, mopping up dead cells and debris. The reality is more complicated, according to scientists led by Jaime Grutzendler at Yale School of Medicine in New Haven, ...

In Mice, Activating TREM2 Tempers Plaque Toxicity, not Load

RESEARCH NEWS 2020-06-26 Research News Another anti-TREM2 antibody looks like a promising candidate for treating Alzheimer’s disease. In the June 24 Journal of Experimental Medicine, researchers led by Marco Colonna at Washington University, St. Louis, and Tina Schwabe, Alector ...

Does RhoA Rein in Microglial Madness?

RESEARCH NEWS 2020-06-26 Research News The task of restraining microglia’s neurotoxic tendencies may fall to a small GTPase called RhoA, according to a study published June 23 in Cell Reports. Scientists led by João Relvas, University of Porto, Portugal, found that deleting RhoA ...

In the Wake of COVID-19: Trials Interrupted, Delayed, Cancelled

COMMUNITY NEWS 2020-06-23 Community News Part 2 of 2 As Alzheimer’s research comes to, scientists are taking stock of the damage. In the academic world, the main cost was time (see Part 1  of this story). For most clinical studies, the damage was more tangible, with at least a ...

Alzheimer’s Research Restarts, Cautiously

COMMUNITY NEWS 2020-06-23 Community News Part 1 of 2 Three months after it shuddered to a halt to contain coronavirus, Alzheimer’s research is powering up again. How did it weather the shutdown? Some three dozen researchers around the world told Alzforum how the pandemic has cost ...

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