46 RESULTS
RESEARCH NEWS 2020-09-26 Research News You’d think that by 2020, pathologists would know all about what amyloid plaques look like? Well, no. Researchers led by Jeroen Hoozemans at Amsterdam University Medical Center have characterized what they believe to be a distinct type. As r
RESEARCH NEWS 2020-09-25 Research News For carriers of a pathogenic mutation in the progranulin gene, variants in another gene—TMEM106b—strongly influence when, and even if, they will develop frontotemporal dementia. A trio of recent papers, published in August and September in E
RESEARCH NEWS 2020-09-24 Research News Microglia can help or hinder in Alzheimer’s disease. A protective variant of the microglial gene phospholipase C-γ2 (PLCG2) may shed light on what makes the difference. In the September 11 Molecular Neurodegeneration, researchers led by Mikk
RESEARCH NEWS 2020-09-18 Research News Under rare circumstances, Aβ seeds can be transferred to people during medical procedures. Researchers have turned up a few cases of tissue transplants or hormones from cadavers triggering amyloidosis in the brains or blood vessels of recipi
RESEARCH NEWS 2020-09-18 Research News As Aβ accumulates in a person’s brain during the long preclinical stage of Alzheimer’s disease, deficits in learning emerge prior to impairments in episodic memory, according to a study published in Neurology on September 4. Cognitively norm
RESEARCH NEWS 2020-09-12 Research News Pathogenic mutations within coding regions almost always change protein function. For a missense mutation in the DJ-1 gene that causes Parkinson’s disease, an entirely different mechanism may be at play. According to a study led by led by Re
RESEARCH NEWS 2020-09-11 Research News A combination drug that targets cellular stress nudged, ever so slightly, progression of amyotrophic lateral sclerosis in a Phase 2 trial. Researchers led by Sabrina Paganoni at Massachusetts General Hospital, Boston, reported the findings i
RESEARCH NEWS 2020-09-09 Research News Different genetic mutations can converge on the same downstream pathology. The C9ORF72 repeat expansion and progranulin haploinsufficiency both trigger the RNA-binding protein TDP-43 to abandon the nucleus and settle in cytoplasm. TDP-43 dep
COMMUNITY NEWS 2020-09-04 Community News When Peter Davies passed away on August 26, the Alzheimer’s research community lost a brilliant mind, and a truly generous human being. Davies died at age 72, after a long battle with cancer. His discoveries paved the way for the first Alzh
RESEARCH NEWS 2020-09-04 Research News Neurexin proteins lie in the presynapse and pentraxins in the post, and never the twain shall meet. But what if they did? By designing a small protein that binds to both, researchers in Japan, Germany, and the U.K., have created an extracell
RESEARCH NEWS 2020-09-03 Research News Neuroinflammation and Aβ deposition are two hallmarks of AD, and now, a study published September 3 in Nature is forging an alluring mechanistic link between them. Researchers led by Yueming Li at Memorial Sloan Kettering Cancer Center in Ne
COMMUNITY NEWS 2020-09-01 Community News Trying out a new conference format in this pandemic era, the Alzheimer’s Disease Genetics Global Symposium starts September 1 and will run on demand through much of the month. For three weeks, registrants can view presentations as they plea
RESEARCH NEWS 2020-08-29 Research News Mice fail to model many aspects of Alzheimer’s disease. Could monkeys capture the disease more fully? In a preprint posted to bioRxiv on August 24, researchers led by Takaomi Saido, RIKEN Center for Brain Science, Wako, and Erika Sasaki, Cen
RESEARCH NEWS 2020-08-28 Research News For the first time, researchers have solved the molecular structure of LRRK2, a major risk factor for Parkinson’s and autoimmune diseases. Structural biologists at the University of California, San Diego, used innovative methods to provide t
RESEARCH NEWS 2020-08-28 Research News As a group, women may be more likely than men to develop Alzheimer’s disease, but once they have it, they cope better and live longer. A study published August 26 in Science Translational Medicine credits a second X chromosome with some of t
