199 RESULTS
RESEARCH NEWS 2020-08-29 Research News Mice fail to model many aspects of Alzheimer’s disease. Could monkeys capture the disease more fully? In a preprint posted to bioRxiv on August 24, researchers led by Takaomi Saido, RIKEN Center for Brain Science, Wako, and Erika Sasaki, Cen
RESEARCH NEWS 2020-08-28 Research News For the first time, researchers have solved the molecular structure of LRRK2, a major risk factor for Parkinson’s and autoimmune diseases. Structural biologists at the University of California, San Diego, used innovative methods to provide t
RESEARCH NEWS 2020-08-28 Research News As a group, women may be more likely than men to develop Alzheimer’s disease, but once they have it, they cope better and live longer. A study published August 26 in Science Translational Medicine credits a second X chromosome with some of t
RESEARCH NEWS 2020-08-21 Research News Best known for its role in churning out Aβ peptides as the catalytic subunit of γ-secretase, presenilin-1 may also promote digestion of those Aβ peptides within microglia. That is the upshot of a study published August 13 in Molecular Psychi
RESEARCH NEWS 2020-08-21 Research News When too much tau invades dendrites, synaptic signaling goes haywire. Now, researchers led by Costantino Iadecola at Weill Cornell Medical College, New York, accuse this mislocalized tau of disrupting neurovascular coupling as well. In the A
RESEARCH NEWS 2020-08-19 Research News In the healthy central nervous system, blood flows where neurons need it most. Now, researchers led by Adriana Di Polo at the University of Montreal help explain why. In the August 12 Nature, they describe a new mechanism for fine control of
RESEARCH NEWS 2020-08-14 Research News Though it carries nary a human transgene, a new mouse model developed many of the hallmark features of Alzheimer’s disease, according to a study published August 14 in Science Advances. Mice deficient in the WD domain of the autophagy protei
RESEARCH NEWS 2020-08-14 Research News Researchers are beginning to uncover genetic factors that modify the ability of amyloid plaques to spur tau pathology. Now, scientists led by Michael Ewers at Ludwig-Maximilians University, Munich, add a longevity gene into the mix. In a pre
CONFERENCE COVERAGE 2020-08-12 Conference Coverage This year’s virtual Alzheimer’s Association International Conference featured no new efficacy data from large clinical trials, but there were some snippets of news from early phase studies. CT1812 by Cognition Therapeutics (CogRx) seem
CONFERENCE COVERAGE 2020-08-12 Conference Coverage At this year’s virtual Alzheimer’s Association International Conference, researchers from Novartis and the Banner Alzheimer’s Institute presented highly anticipated follow-up data from the massive Generation 1 and 2 Phase 3 trials. The
CONFERENCE COVERAGE 2020-08-08 Conference Coverage Without the millions of thriving synapses that link them, neurons in the brain are useless. The crumbling of these tiny connective structures is widely viewed as the proximal step to cognitive impairment in Alzheimer’s disease. Yet, re
RESEARCH NEWS 2020-08-08 Research News The fate of aducanumab now rests in the hands of regulators at the U.S. Food and Drug Administration (FDA). Biogen of Cambridge, Massachusetts, and Eisai Co. Ltd., Tokyo, announced on August 7 that the agency had accepted its Biologics Licen
CONFERENCE COVERAGE 2020-08-07 Conference Coverage Having established that poor cardiovascular health in midlife increases the risk of cognitive decline and dementia as a person ages, scientists are now pushing to see if the same relationship might hold true even earlier in life. Indee
RESEARCH NEWS 2020-08-04 Research News The idea that herpes simplex virus type 1 (HSV-1) stokes the fires of Alzheimer’s disease has gained traction in recent years. If true, how would such a common infection trigger neurodegenerative disease in some people, but not others? A stu
CONFERENCE COVERAGE 2020-08-04 Conference Coverage At this year’s virtual Alzheimer’s Association International Conference, researchers presented an update to “Dementia prevention, intervention, and care,” the 2017 report commissioned by The Lancet. Published July 30, the new report id
