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Could Getting Enough REST Extend Your Life?

RESEARCH NEWS 2019-10-18 Research News Why do some people age better than others? In the October 16 Nature, researchers led by Bruce Yankner at Harvard Medical School once again credit the repressor element 1-silencing transcription factor (REST). People who lived to a ripe old ...

Tau Natively Unstructured? Not Always, New Study Says

RESEARCH NEWS 2019-10-17 Research News Researchers for years thought that tau was a natively unstructured protein. Then how in the world do its supposedly disordered monomers give rise to the orderly stacks of tau molecules seen in tau fibrils? Using chemical cross-linkers to ...

In Tauopathy, ApoE Destroys Neurons Via Microglia

RESEARCH NEWS 2019-10-17 Research News ApoE4 delivers a blow to neurons in mouse models of tauopathy but, according to a paper published October 10 in the Journal of Experimental Medicine, it only does so if mice have their microglia. Researchers led by David Holtzman at ...

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