Phase 3 Trial Suggests Pimavanserin Assuages Psychosis in Dementia

RESEARCH NEWS 2019-09-18 Research News A Phase 3 trial of pimavanserin was halted early when the study met its primary endpoint of delaying relapse to psychosis in people with dementia, according to a press release  by its sponsor, Acadia Pharmaceuticals. Pimavanserin —a ...

Chris Dobson, Master of Protein Folding Research, Dies at 69

COMMUNITY NEWS 2019-09-17 Community News Researchers are mourning the passing of a giant in the field of protein chemistry. Christopher Dobson succumbed to cancer on September 8, a month shy of his 70th birthday. Dobson, who had worked at the University of Cambridge since 2001, ...

Among AD Mutations, Only ApoE4 Seems to Hobble Microglia

RESEARCH NEWS 2019-09-14 Research News New research adds to the evidence that ApoE regulates microglial health and activity. Researchers led by Tarja Malm at the University of Eastern Finland, Kuopio, examined how several Alzheimer’s risk factors affect microglia generated from ...

Results of Ladostigil Trial Published

RESEARCH NEWS 2019-09-13 Research News In a second Phase 2 strikeout, the small-molecule drug ladostigil missed its primary endpoint of curbing progression from mild cognitive impairment to AD, though people on a low-dose regimen did have less brain shrinkage over three years ...

Tiny Brain Structure Plays Big Role in Memory

RESEARCH NEWS 2019-09-13 Research News The humble locus coeruleus, a minute speck of tissue nestled deep in the brain stem, has received relatively scant attention in studies of cognitive decline. Now, data published September 9 in Nature Human Behavior add to a recent spate of ...

Hello Mitochondriomics: Tagging Method Identifies Different Subtypes

RESEARCH NEWS 2019-09-11 Research News Mitochondria may be the universal powerhouses of eukaryotic cells, but there is more to these organelles than just ATP production. According to a paper in the September 9 Nature Neuroscience, mouse mitochondria express distinct subsets of ...

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