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High and Low Hemoglobin Levels Tied to Alzheimer’s

RESEARCH NEWS 2019-08-02 Research News A study that followed more than 12,000 people for over 12 years adds significant weight to the idea that hemoglobin level is an important risk factor for Alzheimer’s and other dementias. Scientists led by M. Arfan Ikram at Erasmus Medical ...

Ribosomal Protein Spurs Faulty Translation of Nucleotide Repeats

RESEARCH NEWS 2019-08-02 Research News A GGGGCC hexanucleotide repeat expansion in intron 1 of the C9ORF72 gene causes familial amyotrophic lateral sclerosis and frontotemporal dementia. Aberrant translation of this expansion results in toxic poly-dipeptides that build up in the ...

Human Microglia Make Themselves at Home in Mouse Brain

RESEARCH NEWS 2019-08-01 Research News As microglia become more central to Alzheimer’s research, researchers are seeking better model systems to study their in vivo behavior. In culture, the cells rapidly alter their gene expression, and mouse microglia respond differently to ...

AbbVie’s Tau Antibody Flops in Progressive Supranuclear Palsy

RESEARCH NEWS 2019-07-26 Research News According to an industry report today, AbbVie has called a halt to the Phase 2 trial of its anti-tau antibody ABBV-8E12 for progressive supranuclear palsy after it failed a futility analysis. AbbVie announced the termination during a ...

Anatomy News Flash: Brain Drains Lymphatic Fluid Through Its Base

RESEARCH NEWS 2019-07-26 Research News The 2015 discovery of lymphatic vessels in the brain’s meninges threw open a door to seeing how this still-mysterious organ clears waste. Subsequent work showed that these vessels, which reside in the brain’s outermost membrane, the dura ...

Physical Activity May Shield the Brain from the Onslaught of Aβ

CONFERENCE COVERAGE 2019-07-25 Conference Coverage Physical activity not only benefits the heart and the body, it may also shield the brain from the damaging effects of Aβ. That’s according to findings presented at the Alzheimer’s Association International Conference, held July 14–18 ...

New PET Staging Scheme for Amyloid?

CONFERENCE COVERAGE 2019-07-25 Conference Coverage Scientists are becoming more nuanced in how they use amyloid scans—not just to detect the presence of Alzheimer’s pathology, but also to pinpoint disease stage. At this year’s Alzheimer’s Association International Conference, held July ...

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