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Familial AD Mutations, β-CTF, Spell Trouble for Endosomes

RESEARCH NEWS 2019-08-19 Research News Faltering endosomal trafficking appears to be the common modus operandi by a range of familial Alzheimer’s mutations. In the August 14 Neuron, researchers led by Marc Tessier-Lavigne of Stanford University reported initial findings from a ...

ApoE4 Glia Bungle Lipid Processing, Mess with the Matrisome

RESEARCH NEWS 2019-08-16 Research News ApoE4 predisposes people to Alzheimer’s disease by modulating astrocytes and microglia, suggest researchers led by Julia TCW and Alison Goate at the Icahn School of Medicine at Mount Sinai, New York. In a preprint on bioRχiv, the researchers ...

Paper Alert: MS4A Variants May Sway Alzheimer’s Risk Via TREM2

RESEARCH NEWS 2019-08-15 Research News Variants in the MS4A gene cluster influence AD risk, at least in part, by tweaking levels of another AD risk factor, TREM2. In a study published in Science Translational Medicine on August 14, researchers co-led by Bruno Benitez, Celeste ...

Geneticists Seek Out Rare Contributors to Alzheimer’s

CONFERENCE COVERAGE 2019-08-15 Conference Coverage At one end of the Alzheimer’s disease genetic spectrum lie the catastrophic mutations in APP and presenilin that lead to autosomal-dominant, early onset AD. At the other end are dozens of common variants that each contribute a smidgen ...

AD Genetic Risk Tied to Changes in Microglial Gene Expression

RESEARCH NEWS 2019-08-09 Research News Geneticists have found dozens of loci that associate with Alzheimer’s disease, but the functional variants and even the genes that underlie these associations often remain elusive. Now, researchers led by Alison Goate and Edoardo Marcora at ...

Aβ Dimers Block Glutamate Uptake, Fire Up Synapses

RESEARCH NEWS 2019-08-09 Research News Soluble Aβ sends neurons into a hyperactive frenzy, but scientists don’t know why. New evidence suggests that the peptide causes the excitatory neurotransmitter glutamate to build up in synapses, making neurons hyperactive. In the August 9 ...

Rare Luck: Two Copies of ApoE2 Shield Against Alzheimer’s

CONFERENCE COVERAGE 2019-08-08 Conference Coverage Mention ApoE and Alzheimer’s, and the conversation turns to the E4 allele, the strongest susceptibility gene for the disease. But ApoE has another side, in ApoE2. Though this isoform protects against AD, scientists have barely studied ...

Colombian Cohort Delivers Data on Blood NfL

CONFERENCE COVERAGE 2019-08-08 Conference Coverage At the Alzheimer’s Association International Conference, held July 14–18 in Los Angeles, a blood test indicating that neurons in the brain are degenerating generated considerable buzz. Eric Reiman, Banner Alzheimer’s Institute, Phoenix ...

Crenezumab Update: Baseline Data from Colombian Prevention Trial

CONFERENCE COVERAGE 2019-08-08 Conference Coverage A subset of the world’s largest known kindred of autosomal-dominant Alzheimer’s disease, near the Colombian city of Medellin, have enrolled in the Banner Alzheimer Prevention Initiative Autosomal Dominant Alzheimer’s Disease trial. It ...

Colleagues Mourn Loss of Rahul Desikan, Age 41, to ALS

COMMUNITY NEWS 2019-08-08 Community News Neuroscientists are mourning the loss of a beloved colleague and innovator. At the age of 41, Rahul Desikan died of amyotrophic lateral sclerosis (ALS)—a devastating neurodegenerative disease that he studied. Despite being struck with an ...

ASOs: Wave of the Future in Alzheimer’s Therapeutics?

CONFERENCE COVERAGE 2019-08-02 Conference Coverage When participants in the Dominantly Inherited Alzheimer’s Network (DIAN) met in Los Angeles on July 13, they heard from their at-risk fellow travelers (see Part 1 of this series), learned how their tissue donations continue to advance ...

Genetics Propels DIAN Toward Therapies

CONFERENCE COVERAGE 2019-08-02 Conference Coverage Each year, the DIAD family conference held in advance of the Alzheimer's Association International Conference features a science update, and this year the focus was on genetics. DIAN families know that the modern era of Alzheimer ...

DIAD: Families from Argentina, Canada, Minnesota Rally a Global Community

CONFERENCE COVERAGE 2019-08-02 Conference Coverage “One day you will tell your story of how you’ve overcome what you are going through now, and it will become part of someone else’s survival guide.” Luciana, 29, DIAN participant. “The disease might lie inside us, but so does the cure.” ...

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