251 RESULTS
RESEARCH NEWS 2019-11-22 Research News Microglia have been firmly linked to amyloid plaques, but scientists are only beginning to examine their relationship to tau tangles. In the November 20 Nature, Michael Heneka and colleagues at the German Center for Neurodegenerative Disease
RESEARCH NEWS 2019-11-22 Research News Treatment with the antibiotic minocycline failed to slow cognitive decline or functional impairment in patients with mild Alzheimer’s disease, according to a November 18 paper in JAMA Neurology. Researchers led by Robert Howard, University C
RESEARCH NEWS 2019-11-16 Research News Most GWAS hits lie in noncoding regions of the genome, making it hard to figure out what they do. To address this, researchers led by Christopher Glass at the University of California, San Diego, analyzed epigenetic data from purified popula
RESEARCH NEWS 2019-11-15 Research News Whether in the wake of a stroke, seizure, massive neuroinflammation, or a blow to the head, the endothelial cells of the blood-brain barrier respond with remarkable similarity, according to a study published in the November issue of Nature N
RESEARCH NEWS 2019-11-15 Research News Lots of evidence suggests dipeptide repeat proteins translated from hexanucleotide repeat expansions in C9ORF72 interfere with transport of proteins in and out of the cell’s nucleus. However, an October 31 paper in Scientific Reports suggest
RESEARCH NEWS 2019-11-13 Research News Updated November 14, 2019 Thirty-somethings take heed. A new study suggests it’s time to take care of your vascular health. Using data from the longest continuously running birth cohort in the world, researchers led by Jonathan Schott of Uni
RESEARCH NEWS 2019-11-08 Research News Researchers are searching for ways to dampen harmful inflammation and boost microglial phagocytosis in the Alzheimer’s brain. In the November 4 Proceedings of the National Academy of Sciences, researchers led by Hee Kyung Jin and Jae-sung Ba
RESEARCH NEWS 2019-11-08 Research News Former professional soccer players are more likely to develop a neurodegenerative disease than the general population, according to a November 7 paper in the New England Journal of Medicine. Researchers led by William Stewart, University of
RESEARCH NEWS 2019-11-07 Research News Just as the clamor about Biogen’s seeking FDA approval for aducanumab with one positive Phase 3 trial started to die down, a Chinese company garnered a regulatory thumbs-up for its drug, also with one Phase 3 trial. On November 2, Shanghai G
RESEARCH NEWS 2019-11-04 Research News In today’s Nature Medicine, a team of researchers led by Yakeel Quiroz, Joseph Arboleda-Velasquez, Francisco Lopera, and Eric Reiman describe the case of a Colombian woman who inherited the autosomal-dominant E280A mutation in presenilin 1 b
RESEARCH NEWS 2019-11-01 Research News Sleep is profoundly restorative for the brain, partly because it clears solutes and waste products. This flushing works best during the deepest periods of sleep, but why is that? Data from the lab of Laura Lewis, Boston University, suggest t
RESEARCH NEWS 2019-11-01 Research News Does ApoE4 affect aspects of Alzheimer’s disease other than amyloidosis? Animal studies have hinted as much, and now several brain imaging studies seem to agree. In a preprint posted to medRχiv on October 8, researchers led by Mark Bondi at
RESEARCH NEWS 2019-11-01 Research News Bucking conventional, i.e., left-leaning, wisdom for amyloid fibrils, Aβ fibrils extracted from the brains of three people with Alzheimer’s disease all twisted to the right. This is apparent in the first-ever structure of Aβ fibrils isolated
RESEARCH NEWS 2019-10-30 Research News In mice, microglia eat synapses. Does this happen in the human brain, too? New data from the labs of Tara Spires-Jones and Barry McColl, both at the University of Edinburgh, suggests as much. In postmortem samples, the researchers uncovered
RESEARCH NEWS 2019-10-30 Research News Constipation of the vesicular transport system in neurons is a core feature of Parkinson’s disease, and two new studies describe small-molecule approaches to get this cellular digestion pathway moving again. On October 16 in Science Translat
