Nixing Complement Protein Protects Neurons in Tauopathy Model

RESEARCH NEWS 2019-08-25 Research News Complement proteins may be helpful when it comes to rallying clearance of hazardous debris from the brain, but scientists believe the immune activators can also inflict irreparable damage to neurons and their synapses. A paper published ...

Blood Pressure: How Low to Prevent Dementia—and When?

RESEARCH NEWS 2019-08-23 Research News Mounting evidence suggests midlife hypertension negatively affects late-life cognition and that treating it could help. Three new papers support this idea. In the August 20 Lancet, researchers led by Marcus Richards, Nick Fox, and Jonathan ...

Spatial Transcriptomics Uncovers Coordinated Cell Responses to Amyloid

RESEARCH NEWS 2019-08-23 Research News With single-cell resolution, scientists now have a good idea of what amyloid plaques do to nearby cells in the brains of mice. Scientists led by Bart De Strooper, KU Leuven, Belgium, used a combination of spatial transcriptomics and in situ ...

Newly Identified Microglia Contain Lipid Droplets, Harm Brain

RESEARCH NEWS 2019-08-23 Research News Microglia in the brain assume a dizzying array of states. Now researchers led by Tony Wyss-Coray at Stanford University, Palo Alto, California, describe a new one: lipid droplet-accumulating microglia (LAM). These lipid-stuffed cells ...

Proteomics Uncovers Potential Markers, Subtypes of Alzheimer’s

CONFERENCE COVERAGE 2019-08-22 Conference Coverage In the last three decades, scientists have made strides in using biomarkers to diagnose Alzheimer’s disease and track its progression. Along with cerebrospinal fluid Aβ, tau, and phospho-tau, a handful of new markers, such as ...

Synaptic Proteins in CSF: New Markers of Cognitive Decline?

CONFERENCE COVERAGE 2019-08-22 Conference Coverage Plasma tests for Aβ and phospho-tau may have stolen the show at this year’s Alzheimer’s Association International Conference, held July 14-18 in Los Angeles, but proteomic and synaptic markers were not that far behind. A neural ...

Why Bother With Round Robins on Blood Tests? Q&A with Kaj Blennow

CONFERENCE COVERAGE 2019-08-21 Conference Coverage At the AAIC conference held July 14–18 in Los Angeles, Kaj Blennow of the University of Gothenburg had his hands full trying to get researchers in the field engaged in the nitpicky drudgery of validation, standardization, and ...

Are Aβ Blood Tests Ready for Prime Time?

CONFERENCE COVERAGE 2019-08-21 Conference Coverage In the short space of two years, the erstwhile fantasy of a blood test for Alzheimer’s disease has become reality. Or so it seems. At the 2017 Alzheimer’s Association International Conference in London, Randall Bateman, Washington ...

Move Over CSF, P-Tau in Blood Also Tells Us There’s Plaque in the Brain

CONFERENCE COVERAGE 2019-08-20 Conference Coverage From day one at this year’s AAIC, held July 14-18 in Los Angeles, conference halls and corridors buzzed with the sound of “p-tau.” Scientists from Randall Bateman ’s lab at Washington University, St. Louis, reported that among ...

Move Over Aβ, CSF P-Tau Tells Us There’s Plaque in the Brain

CONFERENCE COVERAGE 2019-08-20 Conference Coverage Just as labs around the globe are racing to start marketing plasma Aβ tests, along come new contenders to rattle the field. At this year’s AAIC, held July 14-18 in Los Angeles, scientists reported that certain amino acids on the ...

Familial AD Mutations, β-CTF, Spell Trouble for Endosomes

RESEARCH NEWS 2019-08-19 Research News Faltering endosomal trafficking appears to be the common modus operandi by a range of familial Alzheimer’s mutations. In the August 14 Neuron, researchers led by Marc Tessier-Lavigne of Stanford University reported initial findings from a ...

ApoE4 Glia Bungle Lipid Processing, Mess with the Matrisome

RESEARCH NEWS 2019-08-16 Research News ApoE4 predisposes people to Alzheimer’s disease by modulating astrocytes and microglia, suggest researchers led by Julia TCW and Alison Goate at the Icahn School of Medicine at Mount Sinai, New York. In a preprint on bioRχiv, the researchers ...

Paper Alert: MS4A Variants May Sway Alzheimer’s Risk Via TREM2

RESEARCH NEWS 2019-08-15 Research News Variants in the MS4A gene cluster influence AD risk, at least in part, by tweaking levels of another AD risk factor, TREM2. In a study published in Science Translational Medicine on August 14, researchers co-led by Bruno Benitez, Celeste ...

Geneticists Seek Out Rare Contributors to Alzheimer’s

CONFERENCE COVERAGE 2019-08-15 Conference Coverage At one end of the Alzheimer’s disease genetic spectrum lie the catastrophic mutations in APP and presenilin that lead to autosomal-dominant, early onset AD. At the other end are dozens of common variants that each contribute a smidgen ...

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